Intravitreal injections were performed by two operators (KSC and SJL) under the same conditions for all patients. Both eyes were anesthetized with the instillation of 0.5% proparacaine hydrochloride (Alcaine; Alcon, Fort Worth, TX, USA). The eyelids and eyelashes on both sides were prepared with 10% povidone-iodine, and 5% povidone-iodine was instilled onto the conjunctival surface. The operators performed all procedures using aseptic techniques. After the eyelid speculum and sterile drape were placed appositely, prepared bevacizumab (1.25 mg/0.05 mL) was injected using a 30-gauge needle at the superotemporal quadrant 3 to 3.5 mm posterior to the limbus. The bevacizumab ampule was opened just before the procedure, and the solution was dispensed into 1-mL syringes and was kept in aseptic conditions. Any remaining drug was disposed. The procedure on the opposite eye was performed after resterilization and with new gloves, drapes, surgical instruments, and syringes. Every patient was instructed to apply levofloxacin (Cravit; Santen, Osaka, Japan) into their eyes four times a day for one week post-injection.
Levofloxacin cravit
Manufactured by Santen
Sourced in Japan
Levofloxacin (Cravit) is a broad-spectrum antibiotic that belongs to the fluoroquinolone class. It is used to treat various bacterial infections. Levofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, which are essential for bacterial cell division and replication.
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Lab products found in correlation
2 protocols using levofloxacin cravit
1
Intravitreal Bevacizumab Injection Procedure
2
Aberration-Free Laser Corneal Ablation
Check if the same lab product or an alternative is used in the 5 most similar protocols
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The surgery was performed by a single surgeon using the SCHWIND Amaris 500E excimer laser platform (SCHWIND eye-tech-solutions GmbH, Kleinostheim, Germany). Ablations were based on aberration-free algorithms calculated using ORK-CAM software. The ablation profile targets epithelial thickness as 55 μm centrally and 65 μm peripherally according to the population model statistics [6 (link)]. Before ablation, all patients’ examinations were tested by the statistic cyclotorsion control (SCC) and dynamic cyclotorsion control (DCC) was used through the surgery. After ablation, the corneal stromal was irrigated with a cool balanced salt solution and a soft bandage contact lens was applied.
After surgery, the patients were treated with topical 0.5% levofloxacin (Cravit; Santen, Inc) eye drops four times a day for one week, 0.1% fluorometholone (Allergan, Inc) eye drops four to six times daily (tapered over 12 weeks) and preservative-free artificial tears four times daily for at least 6 months. The contact lens were removed once the epithelial closure was completed.
After surgery, the patients were treated with topical 0.5% levofloxacin (Cravit; Santen, Inc) eye drops four times a day for one week, 0.1% fluorometholone (Allergan, Inc) eye drops four to six times daily (tapered over 12 weeks) and preservative-free artificial tears four times daily for at least 6 months. The contact lens were removed once the epithelial closure was completed.
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