FDG PET-CT scans were performed as part of routine clinical practice with coverage from the skull vertex to the upper thigh in all patients. Imaging was acquired on three scanners during the study period, including a 64-slice Philips Gemini TF64 scanner (Philips Healthcare, Best, Netherlands), a 64-slice Discovery 690 scanner (GE Healthcare, Chicago, IL, USA), or a 64-slice Discovery 710 scanner (GE Healthcare, Chicago, IL, USA). Patients were fasted for 6 h before administration of Fluorine-18 FDG intravenously (4 MBq/kg). Serum blood glucose levels were measured prior to radiotracer administration, and if >10 mmol/L, the examination was not performed. PET was performed 60 min after the radiotracer injection. Following the injection, the patient underwent silence protocol to minimise physiological head and neck tracer uptake for the duration of the scan. Standard proprietary time-of-flight iterative reconstruction algorithms were used for PET imaging data. The CT component was performed using a low-dose unenhanced protocol with the following settings: 140 Kv, 80 mAs, tube rotation 0.52 per s, pitch 6, section thickness 3.75 mm.
Discovery 690 scanner
Manufactured by GE Healthcare
Sourced in United States
The Discovery 690 scanner is a medical imaging device manufactured by GE Healthcare. It is designed to capture high-quality images of the human body for diagnostic purposes. The scanner uses advanced imaging technologies to provide detailed information about the internal structures and functions of the body.
Automatically generated - may contain errors
Lab products found in correlation
6 protocols using discovery 690 scanner
1
FDG PET-CT Imaging Protocol for Routine Clinical Practice
2
PET/CT Imaging for Tumor Assessment
Check if the same lab product or an alternative is used in the 5 most similar protocols
+ Expand
All PET/CT studies were performed on a Discovery 690 scanner (General Electric Company). After fasting for at least 6 h, patients with glucose levels below 200 mg/dL were administered 10 mCi of 2-deoxy-2-[fluorine-18]fluoro-D-glucose (18F-FDG) and allowed to rest quietly for a period of 60 min. Patients were then scanned from the head to mid-thigh, followed by 3D PET emission data collection, reconstructed using an ordered subset expectation maximization algorithm (2 subsets, 24 iterations) and CT-based attenuation correction. At least two readers who were blinded to the clinical and genomic data reviewed and verified the tumor lesions on each clinical report. While Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1 limits measurable lesions to ≤ 2 per organ and ≤ 5 lesions in total to evaluate treatment response [44 (link)], we measured the dimension and metabolic activity of up to ten of the most prominent primary and metastatic lesions. The total tumor anatomic burden was defined as the sum of the lesion diameters, and the tumor metabolic activity was estimated by the sum of the SUVmax values.
3
Standardized PET Imaging Protocol for Lung Cancer
Check if the same lab product or an alternative is used in the 5 most similar protocols
+ Expand
PET imaging was performed using a Discovery 690 scanner (General Electric HealthCare, Chicago, Illinois, USA). The standard protocol included CT attenuation correction imaging and lung window reconstruction with the following parameters: 80–210 mA (depending on patient size), 3.75 mm section thickness, and 0.8-second gantry rotation speed.
Whole-body PET with 2.5 mm section thickness was performed using non-attenuation corrected (NAC), measured attenuation corrected (MAC) images, and the Q.Clear algorithm. The time between FDG injection and data acquisition was 45–60 min. Standard reconstructions included: Q.Clear, SharpIR, Q.AC, and VUE Point HD. The maximum SUV was calculated using the Pet Odyssey software, based on the patient’s weight and the administered dose of the isotope.
Each study was independently assessed by two diagnosticians, a radiologist and a nuclear medicine specialist. The tumor grade was determined by an experienced pathologist devoted to lung pathology. Standard light microscopy images with hematoxylin and eosin staining were used.
Whole-body PET with 2.5 mm section thickness was performed using non-attenuation corrected (NAC), measured attenuation corrected (MAC) images, and the Q.Clear algorithm. The time between FDG injection and data acquisition was 45–60 min. Standard reconstructions included: Q.Clear, SharpIR, Q.AC, and VUE Point HD. The maximum SUV was calculated using the Pet Odyssey software, based on the patient’s weight and the administered dose of the isotope.
Each study was independently assessed by two diagnosticians, a radiologist and a nuclear medicine specialist. The tumor grade was determined by an experienced pathologist devoted to lung pathology. Standard light microscopy images with hematoxylin and eosin staining were used.
4
Dual PET/CT Imaging of Prostate Cancer
Check if the same lab product or an alternative is used in the 5 most similar protocols
+ Expand
All patients underwent 2 PET/CT scans, 68 Ga-PSMA PET/ceCT and 18 F-FDG PET/CT, 1-5 d apart using a Discovery 690 scanner (GE Healthcare). We used 68 Ga-PSMA with the precursor PSMA-11 (Good Manufacturing Practices quality; ABX). Administered doses were 148 MBq of 68 Ga-PSMA and 444 MBq of 18 F-FDG. CT acquisition was performed at 100, 120, or 140 keV, depending on the patient's habitus. PET reconstruction included time of flight; 3 iterations; 18 subsets with the filter cutoff set at 6.4; a standard z-axis filter; a matrix size of 256; and Q Clear (GE Healthcare) image reconstruction.
5
Dynamic PET-CT Imaging of Prostate Cancer
Check if the same lab product or an alternative is used in the 5 most similar protocols
+ Expand
PET-CT was performed on a 64 slice Discovery 690 scanner (GE Healthcare, Waukesha, Wisconsin, USA). 4 MBq per kilogram of body mass of Fluorine-18 Ethyl-Choline was injected intravenously. A dynamic single bed position list mode study was acquired through the pelvis from 0 to 20 minutes following injection. At 60 minutes PET images were acquired from skull base to upper thighs. Finally, a delayed single bed position pelvic PET was performed at 90 minutes. Low-dose, unenhanced CT was also performed: 140 kV; 80 mAs; tube rotation time 0.5s per rotation; pitch 6; 3.75 mm slices (matching PET slice thickness). Patients maintained shallow respiration during the examination.
Images were reconstructed using a standard ordered subset expectation maximization (OSEM) algorithm with CT used for attenuation correction. Both non-attenuation corrected and attenuation corrected datasets were reconstructed.
Images were reconstructed using a standard ordered subset expectation maximization (OSEM) algorithm with CT used for attenuation correction. Both non-attenuation corrected and attenuation corrected datasets were reconstructed.
6
68Ga-PSMA-11 PET/CT Imaging Protocol
Check if the same lab product or an alternative is used in the 5 most similar protocols
+ Expand
No specific patient preparation such as fasting or hydration was requested for 68 Ga-PSMA-11 PET/CT scans. Whole-body PET/CT images were acquired from vertex to mid thighs with 8 bed positions and 3-min emission scans per bed position at 51-68 min (mean 6 SD, 57.1 6 5.9 min) after intravenous administration of the 68 Ga-PSMA-11. The administered activity was 130-144 MBq (mean 6 SD, 137 6 4 MBq). The images were reconstructed using an ordered-subset expectation maximization algorithm with 2 iterations and 32 subsets for the Discovery 600 scanner (GE Healthcare) (6 patients) and 2 iterations and 24 subsets for the Discovery 690 scanner (GE Healthcare) (1 patient). The CT acquisition was performed for attenuation correction, in helical mode, using 120 kV, 10 mAs, a 512 • 512 matrix, and an 867-mm field of view in 22.5 s. The CT amperage was reduced to 10 mAs, as requested by the local Institutional Review Board, to decrease the radiation exposure. The duration of the PET/CT examination ranged from 24 to 38 min (mean 6 SD, 30.2 6 4.9 min).
About PubCompare
Our mission is to provide scientists with the largest repository of trustworthy protocols and intelligent analytical tools, thereby offering them extensive information to design robust protocols aimed at minimizing the risk of failures.
We believe that the most crucial aspect is to grant scientists access to a wide range of reliable sources and new useful tools that surpass human capabilities.
However, we trust in allowing scientists to determine how to construct their own protocols based on this information, as they are the experts in their field.
Ready to get started?
Sign up for free.
Registration takes 20 seconds.
Available from any computer
No download required
Revolutionizing how scientists
search and build protocols!