Debrisoquine sulfate, 4-nitrobenzoic acid (4 (link)–NBA) and UPLC-grade solvents such as acetonitrile, water and isopropanol were purchased from Fisher Scientific (Hanover Park, IL). 4-Guanidinobutyric acid, riboflavin, retinoic acid, (−)-epinephrine, hippuric acid, nicotinic acid, S-(5′-adenosyl)-L-homocysteine, taurine, uric acid, homovanillic acid, acetylcarnitine and carnitine were purchased from Sigma-Aldrich®, (St. Louis, MO). The METLIN (3 (link)) database (La Jolla, CA) was used for tandem MS (MS/MS) validations of 4-aminobutanoate, 3-hydroxybutanoate and quinolinic acid.
4 guanidinobutyric acid
Manufactured by Merck Group
4-Guanidinobutyric acid is a chemical compound that serves as a laboratory reagent. It is a crystalline solid that is soluble in water and organic solvents. The compound is used in various chemical and biochemical applications, but a detailed description of its specific functions or intended uses is not provided to maintain an unbiased and factual approach.
Automatically generated - may contain errors
Lab products found in correlation
Acetonitrile, by Thermo Fisher Scientific (1 mentions)
Isopropanol, by Thermo Fisher Scientific (1 mentions)
Retinoic acid, by Merck Group (1 mentions)
Uric acid, by Merck Group (1 mentions)
Taurine, by Merck Group (1 mentions)
Nicotinic acid, by Merck Group (1 mentions)
Riboflavin, by Merck Group (1 mentions)
Epinephrine, by Merck Group (1 mentions)
Hippuric acid, by Merck Group (1 mentions)
Homovanillic acid, by Merck Group (1 mentions)
Carnitine, by Merck Group (1 mentions)
Acetylcarnitine, by Merck Group (1 mentions)
Debrisoquine sulfate, by Thermo Fisher Scientific (1 mentions)
S 5 adenosyl l homocysteine, by Merck Group (1 mentions)
3 guanidinopropionic acid, by Merck Group (1 mentions)
Phenformin hydrochloride, by Cayman Chemical (1 mentions)
Metformin hydrochloride, by Cayman Chemical (1 mentions)
2 protocols using 4 guanidinobutyric acid
1
Comprehensive Metabolite Identification via UPLC-MS
2
Synthesis and Characterization of Galegine Hemisulfate
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Metformin hydrochloride (Cayman Chemical), buformin hydrochloride (Enamine), phenformin hydrochloride (Cayman Chemical), L-arginine hydrochloride (Acros), agmatine sulfate (Fluka), 4-guanidinobutyric acid (Fluka) and 3-guanidinopropionic acid (Sigma) were obtained with high purity (>97%).
Galegine hemisulfate was synthesized via the condensation reaction of a thiourea with the alkylamine using a procedure adapted from Williams et al.66 2-methyl-2-thiopseudourea hemisulfate, 7 mmol, (Sigma) was added to 8 mmol 3-methyl-2-buten-1-amine (A2B Chem) in 5 mL of water and stirred overnight at room temperature. The reaction produced precipitate which was dried on a porcelain plate and washed with methanol. The solids were then recrystallized in methanol to produce galegine hemisulfate in high purity (>95%) as determined by NMR. 1H-NMR (DMSO-d6, 400 MHz) δ (ppm) 1.62 (s, 3H), 1.68 (s, 3H), 3.64 (br, 2H), 5.16 (t, 1H), 7.62 (br, 4H), 8.46 (br, 1H). 1H-NMR experiments were conducted using the Varian Unity Inova 400 MHz NMR system and VnmrQ 2.2 software.
Galegine hemisulfate was synthesized via the condensation reaction of a thiourea with the alkylamine using a procedure adapted from Williams et al.66 2-methyl-2-thiopseudourea hemisulfate, 7 mmol, (Sigma) was added to 8 mmol 3-methyl-2-buten-1-amine (A2B Chem) in 5 mL of water and stirred overnight at room temperature. The reaction produced precipitate which was dried on a porcelain plate and washed with methanol. The solids were then recrystallized in methanol to produce galegine hemisulfate in high purity (>95%) as determined by NMR. 1H-NMR (DMSO-d6, 400 MHz) δ (ppm) 1.62 (s, 3H), 1.68 (s, 3H), 3.64 (br, 2H), 5.16 (t, 1H), 7.62 (br, 4H), 8.46 (br, 1H). 1H-NMR experiments were conducted using the Varian Unity Inova 400 MHz NMR system and VnmrQ 2.2 software.
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