Captopril

Manufactured by Thermo Fisher Scientific

Sourced in Germany

Captopril is a laboratory product designed to measure the concentration of captopril, a medication used to treat high blood pressure and heart failure. The core function of this equipment is to provide accurate and reliable analytical results for captopril levels in various samples.

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Lab products found in correlation

5 protocols using captopril

Affinity Purification of Angiotensin-Converting Enzyme

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Sodium tetraborate (Na₂B₄O₇.10H₂O), HepesNa, Coomassie Brillant Blue R-250, N-[3-(2-Furyl)acryloyl]-L-phenylalanyl-glycyl-glycine (FAPGG), lisinopril, and Coomassie Brillant Blue G-250 were bought from Sigma-Aldrich. NHS-activated Sepharose 4 Fast Flow was obtained from GE Healthcare Life Sciences. Captopril was purchased from Alfa Aesar.

Aydin F., Turkoglu V, & Bas Z. (2021). Purification and characterization of angiotensin-converting enzyme (ACE) from sheep lung. Molecular Biology Reports, 48(5), 4191-4199.

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Analytical Standards Chemical Analysis

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All the
reagents were of analytical grade
unless otherwise stated. Hydrogen tetrachloroaurate trihydrate (min.
99.9%), PESTANAL analytical standards of dithiocarbamate fungicides
(Thiram and Propineb) and organophosphate pesticides (Phorate and
Methamidophos), zofenopril calcium, arginine, asparagine, aspartic
acid, l-cysteine, cystine, dl-homocysteine, glutamine,
glutamic acid, ammonium chloride, lactic acid, magnesium sulfate,
magnesium chloride hexahydrate, sodium sulfide, sodium chloride, sodium
sulfate, sodium bicarbonate, dipotassium hydrogen phosphate, potassium
dihydrogen phosphate, citric acid, tri-sodium citrate, potassium chloride,
calcium chloride dehydrate, uric acid, d(+)-glucose, and
creatinine were obtained from Sigma-Aldrich (Steinheim, Germany). l-Glutathione (reduced), meso-2,3-dimercaptosuccinic acid, d-(−)-penicillamine, N-acetyl-l-cysteine, and captopril were obtained from Alfa Aesar (Karlsruhe,
Germany). Glycine, histidine, lysine, and valine were supplied by
Serva Electrophoresis GmbH (Heidelberg, Germany). Finally, urea (>99.5%)
was purchased from Pharmacia Biotech AB (Uppsala, Sweden) and HPLC-grade
solvent from Fischer Scientific (Loughborough, U.K.).

Kostara A., Tsogas G.Z., Vlessidis A.G, & Giokas D.L. (2018). Generic Assay of Sulfur-Containing Compounds Based on Kinetics Inhibition of Gold Nanoparticle Photochemical Growth. ACS Omega, 3(12), 16831-16838.

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Captopril Regimen for Irradiated Mice

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All animal protocols were approved by the Institutional Animal Care and Use Committee at the University of Rochester and conform to National Institutes of Health guidelines. Male C57BL/6 mice (6-8 weeks of age, 22-26 g) were purchased from The Jackson Laboratory (Bar Harbor, Maine). Mice were randomized into the various treatment groups, and initially housed 5 to a cage with access to food (standard laboratory chow) and water ad libitum. Mice were weighed weekly. Captopril (Alfa Aesar, Ward Hill, Massachusetts), dissolved in drinking water at a dose of 0.3g/L, was administered starting 5 days before irradiation and maintained throughout the course of the experiment.

Groves A.M., Paris N., Hernady E., Johnston C.J., Aljitawi O., Lee Y.F., Kerns S.L, & Marples B. (2023). Prevention of Radiation-Induced Bladder Injury: A Murine Study Using Captopril. International journal of radiation oncology, biology, physics, 115(4).

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Synthesis and Characterization of Bioactive Compounds

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The following compounds were purchased: VbP (3719, Tocris), MeBs (Millipore, 200485, Batimistat (Tocris, 2691), CHR-2797 (Tocris, 3595), actinonin (Enzo, ALX-260–128), apstatin (SBCT, sc-201309), SC57461 A (Tocris, 3107), HFI-142 (R&D Systems, 5627), fumagillin (ApexBio, A4407), Captopril (Thermo Fisher, 11–101–5083), S17092 (Millipore, SML0181), and butabindide oxalate (Thermo Fisher, 1323/10). Compound 8j^{[9 (link)]} and CQ31^{[14 ]} were synthesized following previously published protocols.

Gregory S.M, & Sweder K.S. (2001). Deletion of the CSB homolog, RAD26, yields Spt– strains with proficient transcription-coupled repair. Nucleic Acids Research, 29(14), 3080-3086.

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Captopril and Lisinopril Characterization

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Captopril and lisinopril (Mw_Captopril = 217.29 g/mol and Mw_lisinopril = 441.52 g/mol; the chemical
structure is displayed in Scheme 1) were purchased from Sigma-Aldrich (UK) and used as
received. Samples for solution characterization were prepared by dissolving
weighed amounts of Captopril or lisinopril with weighed amounts of
ultrapure water (18 MΩ ThermoFisher Barnstead). Samples for
crystallization were prepared by mixing weighed amounts of Captopril
or lisinopril with measured volumes of diethyl ether. The pH measurements
were performed with a Mettler Toledo FiveEasy pH meter with a Sigma-Aldrich
micro-pH combination electrode (glass body).

Castelletto V., Seitsonen J., Ruokolainen J., Barnett S.A., Sandu C, & Hamley I.W. (2021). Self-Assembly of Angiotensin-Converting Enzyme Inhibitors Captopril and Lisinopril and Their Crystal Structures. Langmuir, 37(30), 9170-9178.

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