Nfκb inhibitor bay 11 7085

Manufactured by Merck Group

NFκB inhibitor Bay 11-7085 is a chemical compound that inhibits the activation of the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling pathway. It functions by blocking the phosphorylation and subsequent degradation of the NF-κB inhibitor IκBα, thereby preventing the nuclear translocation and activation of NF-κB.

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Lab products found in correlation

Pi3k inhibitor ly294002, by Cell Signaling Technology (2 mentions) Sb415286, by Merck Group (1 mentions) A1070722, by Bio-Techne (1 mentions) α naphthoflavone, by Merck Group (1 mentions) Ch 223191, by R&D Systems (1 mentions) Oxidized 1 palmitoyl 2 arachidonoyl sn glycero 3 phosphocholine oxpapc, by InvivoGen (1 mentions)

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BAY 11-7085 (50 citations)

2 protocols using nfκb inhibitor bay 11 7085

Modulation of RA FLS Signaling

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RA FLS were serum starved in DMEM containing 0.1% FBS. FLS were then were preincubated with either 0.5 μM NFκB inhibitor Bay 11-7085 (Sigma-Aldrich) or 1 μM PI3K inhibitor LY294002 (Cell Signaling Technology) for 1 hour before stimulation with TNFα (5 ng/ml) for 12 hours. For inhibition of GSK3β, serum starved RA FLS were treated with either 20 μM GSK3β inhibitor SB 415286 (iGSK3β_1; Sigma-Aldrich) or 20 nM GSK3β inhibitor A1070722 (iGSK3β_2; Tocris Bioscience) for 12 hours.

Svensson M.N., Zoccheddu M., Yang S., Nygaard G., Secchi C., Doody K.M., Slowikowski K., Mizoguchi F., Humby F., Hands R., Santelli E., Sacchetti C., Wakabayashi K., Wu D.J., Barback C., Ai R., Wang W., Sims G.P., Mydel P., Kasama T., Boyle D.L., Galimi F., Vera D., Tremblay M.L., Raychaudhuri S., Brenner M.B., Firestein G.S., Pitzalis C., Ekwall A.K., Stanford S.M, & Bottini N. (2020). Synoviocyte-targeted therapy synergizes with TNF inhibition in arthritis reversal. Science Advances, 6(26), eaba4353.

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Comparison of Low-Fat and Western Diets

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The control, low-fat diet (catalog #D12450B) contained 20% kcal protein, 70% kcal carbohydrates (35% kcal from sucrose), 10% kcal fat (4.5% kcal from lard). The Western diet (catalog #D12071702) contained 20% kcal protein, 35% kcal carbohydrates (17.5% kcal from sucrose), 45% kcal fat (40% kcal from lard), and 2% cholesterol). Both diets were purchased from Research Diets, Inc. (New Brunswick, NJ). The diets contained no detectable phytoestrogens or xenobiotics. The α-naphthoflavone was purchased from Sigma-Aldrich (St. Louis, MO) and the CH-223191 from R&D Systems, Inc. (Minneapolis, MN). The TLR2/4 inhibitor oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine (ox-PAPC) was purchased from InVivoGen (San Diego, CA), PI3K inhibitor LY294002 from Cell Signaling Technology (Danvers, MA), NF-κB inhibitor BAY11-7085 from Sigma-Aldrich, and IDO1 inhibitor Norharmane from Santa Cruz Biotechnology (Dallas, TX).

Moyer B.J., Rojas I.Y., Kerley-Hamilton J.S., Hazlett H.F., Nemani K.V., Trask H.W., West R.J., Lupien L.E., Collins A.J., Ringelberg C.S., Gimi B., Kinlaw WB I.I.I, & Tomlinson C.R. (2016). Inhibition of the Aryl Hydrocarbon Receptor Prevents Western Diet-Induced Obesity. Model for AHR Activation by Kynurenine via Oxidized-LDL, TLR2/4, TGFβ, and IDO1. Toxicology and applied pharmacology, 300, 13-24.

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