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N 3 chlorophenyl n 4 5 dihydro 1 methyl 4 oxo 1h imidazol 2 yl urea fenobam

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N-(3-chlorophenyl)-N′-(4,5-dihydro-1-methyl-4-oxo-1H-imidazol-2-yl)urea (Fenobam) is a chemical compound used in research applications. It serves as a metabotropic glutamate receptor 5 (mGluR5) antagonist. The core function of this product is to inhibit the activity of mGluR5, which is involved in various cellular processes.

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2 protocols using n 3 chlorophenyl n 4 5 dihydro 1 methyl 4 oxo 1h imidazol 2 yl urea fenobam

1

Pharmacological Modulation of Glutamate Receptors

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Glutamate, Quisqualate (Quis), (S)-3,5-dihydroxyphenylglycine (DHPG), 2-methyl-6-(phenylethynyl)pyridine (MPEP), 7-(hydroxyimino)-cyclopropan[b]chromen-1a-carboxylate ethyl ester (CPCCOEt), (±)-4-(4-aminophenyl)-1,2-dihydro-1-methyl-2-propyl-carbamoyl-6,7-methylenedioxyphthalazine (SYM2206), D-2-amino-5-phosphonopentanoic acid (D-AP5), 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX), and N-(3-chlorophenyl)-N′-(4,5-dihydro-1-methyl-4-oxo-1H-imidazol-2-yl)urea (Fenobam) were purchased from Tocris (Minneapolis, MN). 2-Amino-2-(3-cis/trans-carboxycyclobutyl)-3-(9H-thioxanthen-9-yl) propionic acid (LY393053), 5-methyl-6-(phenylethynyl)-pyridine (5MPEP), methyl (3aR,4S,7aR)-4-hydroxy-4-[(3-methylphenyl)ethynyl]octahydro-1H-indole-1-carboxylate (mavoglurant, AFQ056), 2-chloro-4-((1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-yl)ethynyl)pyridine (basimglurant, RG-7090, RO-4917523), and 4-[5-[(1R)-1-[5-(3-chlorophenyl)-3-isoxazolyl]ethoxy]-4-methyl-4H-1,2,4-triazol-3-yl]pyridine (AZD2066) were originally obtained from Lilly Research Laboratories, Eli Lilly and Company (Indianapolis, IN). Subsequently, they were purchased from MedChemExpress (Monmouth Junction, NJ) or Tocris.
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2

Pharmacological Evaluation of Glutamate Receptors

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Glutamate, quisqualate, (S)-3,5-dihydroxyphenylglycine (DHPG), L-TBA, TBOA, 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX), D-(−)-2-Amino-5-phosphonopentanoic acid (2S)-2-Amino-2-[(1S,2S)-2-carboxycycloprop-1-yl]-3-(xanth-9-yl) propanoic acid (LY341495), N-[4-(2-Bromo-4,5-difluorophenoxy) phenyl]-L-asparagine (WAY 213613), 2-Amino-5,6,7,8-tetrahydro-4-(4-met¬hoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-4H-chromene-3-carbonitrile (UCPH), MPEP, 7-(Hydroxyimino)-cyclopropan [b]chromen-1a-carboxylate ethyl ester (CPCCOEt), and N-(3-Chlorophenyl)-N′-(4,5-dihydro-1-methyl-4-oxo-1H-imidazol-2-yl)urea (fenobam) were purchased from Tocris Bioscience (Ellisville, MO). THA was obtained from Sigma-Aldrich, (St Louis, MO). 2-Amino-2-(3-cis/trans-carboxycyclobutyl)-3-(9H-thioxanthen-9-yl) propionic acid (LY393053) was obtained from Lilly Research Laboratories, Eli Lilly and Company (Indianapolis, IN).
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