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Mct pet ct scanner

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The MCT PET/CT scanner is a medical imaging device that combines positron emission tomography (PET) and computed tomography (CT) technologies. It is designed to capture detailed images of the body's metabolic and anatomical information simultaneously.

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Lab products found in correlation

Biograph 64, by Siemens (3 mentions) Prisma 3t scanner, by Siemens (1 mentions)

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MCT Flow PET/CT scanner Biograph mCT Flow 20-4R PET/CT scanner MCT 64 PET/CT scanner Biograph mCT 64-slice PET/CT scanner Biograph mCT-64 PET/CT scanner Biography mCT PET/CT scanner Biograph mCT PET/CT scanner Biograph 40 mCT PET/CT scanner Biograph mCT Flow PET/CT scanner Biograph mCT X PET/CT scanner

10 protocols using mct pet ct scanner

1

Amyloid PET Imaging Protocol

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Amyloid PET imaging was performed at the Clinical Imaging Research Centre of the National University of Singapore using either the [11C]Pittsburgh Compound B (PiB) or [18F]Flutafuranol amyloid tracer radioligands. A total of 217 subjects underwent a 30 min brain PET scan on an mMR synchronous PET/MR scanner 40 min after intravenous injection of 370 (+/−15%) MBq of [11C]PiB or a 20 min brain PET scan on an mCT PET-CT scanner (Siemens Healthineers GmbH, Erlanger, Germany) 50 min after intravenous injection of 185MBq of [18F]Flutafuranol (range 166–203 MBq). All images were reconstructed using ordinary Poissonordered subsets expectation maximisation with all corrections applied. Amyloid PET images were independently visually interpreted by three raters blinded to the clinical diagnosis of each subject and following the criteria described previously [30 (link),31 (link)]. Using individual parcellated MRI as reference and target region definition based on an in-house developed automated pipeline [32 (link)], a global standardised uptake value ratio (SUVr) was derived from the [11C]PiB scans. On top of that, cortical Aβ status as binary criteria was derived by merging the equivocal scans with the positive Aβ scans [31 (link)].
Chia R.S., Minta K., Wu L.Y., Salai K.H., Chai Y.L., Hilal S., Venketasubramanian N., Chen C.P., Chong J.R, & Lai M.K. (2024). Serum Brevican as a Biomarker of Cerebrovascular Disease in an Elderly Cognitively Impaired Cohort. Biomolecules, 14(1), 75.
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2

Quantitative PET Imaging of Brown Adipose Tissue

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11C-MRB was synthesized at the Yale PET center based on procedures described previously [28 (link)]. The specific activity at the end of synthesis was 639 ± 319 MBq/nmol and the radiochemical purity was ≥ 99.4%. 18F-FDG was purchased from IBA Molecular (USA).
PET imaging was performed using the mCT PET/CT scanner (Siemens/CTI, USA). Subjects were in supine position with arms at their side. Five to six bed positions were used to scan from the head to the lower abdomen. Before each PET scan, a CT scan (2 mm slice thickness) was performed with the same number of bed positions for attenuation correction and to help delineate the BAT region of interest.
For 18F-FDG scans, one cycle through all bed positions was performed, with a 5-min acquisition for each bed position. For 11C-MRB scans, 13 (12, respectively) cycles through all 5 (6, respectively) bed positions were performed, with the following per bed acquisition times: 18 seconds for 2 cycles, 36 seconds for 3 cycles, 72 seconds for 3 cycles, 180 seconds for 3 cycles, 300 seconds for 2 (1, respectively) cycle(s). Images were reconstructed with an OSEM algorithm using point spread function and time-of-flight corrections. Images from different bed positions were combined to provide a whole body image with 363 (for 5 bed positions) or 425-426 (for 6 bed positions) transverse slices.
Hwang J.J., Yeckel C.W., Gallezot J.D., Aguiar R.B., Ersahin D., Gao H., Kapinos M., Nabulsi N., Huang Y., Cheng D., Carson R.E., Sherwin R, & Ding Y.S. (2015). Imaging human brown adipose tissue under room temperature conditions with 11C-MRB, a selective norepinephrine transporter PET ligand. Metabolism: clinical and experimental, 64(6), 747-755.
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3

Dynamic PET/CT Imaging of Canine Model

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The dog was placed feet first in a lateral decubitus position for imaging on a Siemens mCT PET/CT scanner. ECG leads and a respiratory gating belt were placed for cardiac and respiratory motion corrections, respectively. Prior to the PET scan, a non-contrast CT scan (120 kV, 11 mAs, 2.0 mm slices) was performed during temporary detachment from the ventilation to limit respiratory motion artifact. Following the CT scan, 0.185 GBq of [18F]DHMT was injected via the femoral vein and a 2 h dynamic PET scan was performed.
All animal experiment protocols were approved by the Institutional Animal Care and Use Committees at the Yale University School of Medicine (protocol: 2014-11623), according to the guiding principles of the American Physiological Society on research animal use.
Zhang W., Cai Z., Li L., Ropchan J., Lim K., Boutagy N.E., Wu J., Stendahl J.C., Chu W., Gropler R., Sinusas A.J., Liu C, & Huang Y. (2016). Optimized and Automated Radiosynthesis of [18F]DHMT for Translational Imaging of Reactive Oxygen Species with Positron Emission Tomography. Molecules, 21(12), 1696.
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4

Dynamic PET/CT Imaging of Canine Model

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The dog was placed feet first in a lateral decubitus position for imaging on a Siemens mCT PET/CT scanner. ECG leads and a respiratory gating belt were placed for cardiac and respiratory motion corrections, respectively. Prior to the PET scan, a non-contrast CT scan (120 kV, 11 mAs, 2.0 mm slices) was performed during temporary detachment from the ventilation to limit respiratory motion artifact. Following the CT scan, 0.185 GBq of [18F]DHMT was injected via the femoral vein and a 2 h dynamic PET scan was performed.
All animal experiment protocols were approved by the Institutional Animal Care and Use Committees at the Yale University School of Medicine (protocol: 2014-11623), according to the guiding principles of the American Physiological Society on research animal use.
Zhang W., Cai Z., Li L., Ropchan J., Lim K., Boutagy N.E., Wu J., Stendahl J.C., Chu W., Gropler R., Sinusas A.J., Liu C, & Huang Y. (2016). Optimized and Automated Radiosynthesis of [18F]DHMT for Translational Imaging of Reactive Oxygen Species with Positron Emission Tomography. Molecules, 21(12), 1696.
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5

Multimodal Neuroimaging of Alzheimer's Disease

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All subjects received T1-weighted MR scans on a Siemens PRISMA 3T scanner using a sagittal Magnetization Prepared Rapid Gradient Echo (MPRAGE) sequence (TE = 2.22 ms, TR = 2400 ms, flip angle = 8 deg).
PET scans were acquired using a Siemens mCT PET/CT scanner. Subjects were injected with 560 MBq (nominal) of [11C]PiB 50 min prior to the start of PET component of the scans. Prior to the PET, a low dose CT was acquired without contrast for the purpose of attenuation and scatter correction of the PET data. PET emission data were acquired over the interval 50-70 min post-injection. To allow for investigation of possible subject motion during the scan, raw PET data (sinograms) were binned into 4 5-min frames that were then reconstructed by FORE/Filtered back projection. In keeping with our quantitation pipeline, no post-reconstruction filtering was applied. PET reconstruction was performed using the manufacturer’s software and included corrections for scatter, deadtime, random coincidences, and decay.
Laymon C.M., Minhas D.S., Royse S.K., Aizenstein H.J., Cohen A.D., Tudorascu D.L, & Klunk W.E. (2021). Characterization of point-spread function specification error on Geometric Transfer Matrix partial volume correction in [11C]PiB amyloid imaging. EJNMMI Physics, 8, 54.
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6

Dynamic PET Imaging of Amyloid Deposition

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All image processing and analyses were conducted by persons blinded to the clinical status and cognitive test results of participants. Participant preparation consisted of intravenous catheterization followed by the bolus injection (over 10–20 sec) of 10 mCi of 18F-Florbetaben. The PET scans were acquired over a period of 20 minutes in 4×5 minute frames on an MCT PET/CT scanner (Siemens) in dynamic, 3D imaging mode beginning 50 min after injection of 18F- Florbetaben. Transmission scans were done prior to the scan. An accompanying structural CT scan (in-plane resolution = 0.58×0.58 mm, slice thickness = 3mm, field of view = 29.6×29.6 cm2, number of slices = 75) was also acquired in the same machine at the same time as the PET scan.
Gu Y., Razlighi Q.R., Zahodne L.B., Janicki S.C., Ichise M., Manly J.J., Devanand D.P., Brickman A.M., Schupf N., Mayeux R, & Stern Y. (2015). Brain Amyloid Deposition and Longitudinal Cognitive Decline in Nondemented Older Subjects: Results from a Multi-Ethnic Population. PLoS ONE, 10(7), e0123743.
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7

PET Imaging Protocol for Tau Tracer [¹⁸F]PI-2620

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The cohort of this study was scanned with a Biograph 64 or a mCT PET/CT scanner (both Siemens, Erlangen, Germany). A low-dose CT scan preceded the PET acquisition and served for attenuation correction. [18F]PI-2620 PET was performed in a full dynamic 0–60 min setting initiated upon intravenous injection (∼10 s) of 185 ± 10 MBq of the tracer in most of the patients and short imaging windows were used for a subset due to severe disability (11%). PET data were reconstructed iteratively (4 iterations, 21 subsets, 5.0 mm Gauss/ 5 iterations, 24 subsets, 5.0 mm Gauss) with a matrix size of 336 × 336 × 109/400 × 400 × 148, a voxel size of 1.018 × 1.018 × 2.027/1.018 × 1.018 × 1.500 mm3 / and a slice thickness of 2.027/ 1.500 mm. The previously evaluated single 20–40 min frame (Song et al., 2021 (link)) was used for all further analyses in order to allow inclusion of cases with short scans in severely disabled patients (20–40 min or 0–40 min scan).
Schönecker S., Palleis C., Franzmeier N., Katzdobler S., Ferschmann C., Schuster S., Finze A., Scheifele M., Prix C., Fietzek U., Weidinger E., Nübling G., Vöglein J., Patt M., Barthel H., Sabri O., Danek A., Höglinger G.U., Brendel M, & Levin J. (2023). Symptomatology in 4-repeat tauopathies is associated with data-driven topology of [18F]-PI-2620 tau-PET signal. NeuroImage : Clinical, 38, 103402.
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8

Dynamic [18F]PI-2620 and Static [18F]FDG PET Imaging Protocol

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All patients were scanned at the Department of Nuclear Medicine, LMU Munich, with a Biograph 64 or a Siemens mCT PET/CT scanner (both Siemens, Erlangen, Germany). A low-dose CT scan preceded the PET acquisition and served for attenuation correction. [18F]PI-2620-PET was performed in a full dynamic 0–60-min setting initiated upon intravenous injection (~ 10 s) of 185 ± 10 MBq of the ligand. [18F]PI-2620-PET data were reconstructed in a series of 23 frames (6 × 0.5 min, 4 × 1.0 min, 4 × 2.0 min, 9 × 5.0 min). [18F]-FDG-PET was acquired after injection of 125 ± 10 MBq [18F]FDG according to the EANM protocol [23 (link)]: fasting conditions > 6 h with a blood glucose < 120 mg/dl (6.7 mm) at time of scanning, silent room with dimmed light, headphones and blindfold 20 min prior and after injection. [18F]FDG-PET data was reconstructed in a static 30–50-min frame. PET data were reconstructed iteratively (4 iterations, 21 subsets, 5.0-mm Gauss/5 iterations, 24 subsets, 5.0-mm Gauss) with a matrix size of 336 × 336 × 109/ 400 × 400 × 148, a voxel size of 1.018 × 1.018 × 2.027/1.018 × 1.018 × 1.500 mm3 and a slice thickness of 2.027/1.500 mm. Standard corrections with regard to scatter, decay and random counts were used. Both reconstruction algorithms resulted in images with equal spatial resolution (8 × 8 × 7 mm) as validated by Hofmann phantom measures.
Beyer L., Nitschmann A., Barthel H., van Eimeren T., Unterrainer M., Sauerbeck J., Marek K., Song M., Palleis C., Respondek G., Hammes J., Barbe M.T., Onur Ö., Jessen F., Saur D., Schroeter M.L., Rumpf J.J., Rullmann M., Schildan A., Patt M., Neumaier B., Barret O., Madonia J., Russell D.S., Stephens A.W., Roeber S., Herms J., Bötzel K., Levin J., Classen J., Höglinger G.U., Bartenstein P., Villemagne V., Drzezga A., Seibyl J., Sabri O, & Brendel M. (2020). Early-phase [18F]PI-2620 tau-PET imaging as a surrogate marker of neuronal injury. European Journal of Nuclear Medicine and Molecular Imaging, 47(12), 2911-2922.
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9

Radiosynthesis and PET Imaging of [18F]Flutemetamol and [18F]PI-2620

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Radiosynthesis of [18F]flutemetamol was performed as described previously [26 (link)]. [18F]PI-2620 was synthesized using a BOC-protected nitro-precursor automated synthesis module (IBA, Synthera). After semipreparative high-performance liquid chromatography, radiochemical purity was > 97%. Yields were about 30% with a molar activity of 3 × 106 GBq/mmol.
PET data were acquired with a Biograph 64 or a Siemens mCT PET/CT scanner (Siemens Healthineers, Erlangen, Germany) at the Department of Nuclear Medicine, LMU Munich. The [18F]flutemetamol acquisition was conducted in two phases, with a perfusion-weighted scan during 0–10 min post-injection, followed by a second dynamic recording during 90–110 min post-injection [27 (link)]. The [18F]PI-2620-PET acquisition consisted of a dynamic recording during 0–60 min post-injection. The mean injected activity was 191 MBq (range, 151–223 MBq) for [18F]PI-2620-PET and 185 MBq (range, 124–219 MBq) for [18F]flutemetamol.
Völter F., Beyer L., Eckenweber F., Scheifele M., Bui N., Patt M., Barthel H., Katzdobler S., Palleis C., Franzmeier N., Levin J., Perneczky R., Rauchmann B.S., Sabri O., Hong J., Cumming P., Rominger A., Shi K., Bartenstein P, & Brendel M. (2022). Assessment of perfusion deficit with early phases of [18F]PI-2620 tau-PET versus [18F]flutemetamol-amyloid-PET recordings. European Journal of Nuclear Medicine and Molecular Imaging, 50(5), 1384-1394.
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10

Standardized 18F-FDG PET/CT Imaging Protocol

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All 18F-FDG PET/CT scans were performed with a Siemens mCT PET/CT scanner (Siemens Medical Solution, Erlangen, Germany). Patients were fasted for more than 6 h, and blood glucose level was controlled at <7.1 mmol/L, before the intravenous administration of 18F-FDG (3.7 MBq/kg). A scan from the head to the mid-thigh was performed 60 min after injection. The CT scan was obtained at 120 kV, 200 mA and 3 mm thickness. Then PET was obtained in 3-dimensional mode at 2 min/bed. The CT-based, attenuation-corrected PET images were reconstructed with an iterative algorithm.
Lu X., Wei A., Yang X., Liu J., Li S., Kan Y., Wang W., Wang T., Zhang R, & Yang J. (2022). The Role of Pre-therapeutic 18F-FDG PET/CT in Pediatric Hemophagocytic Lymphohistiocytosis With Epstein-Barr Virus Infection. Frontiers in Medicine, 8, 836438.
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