Cg rag1 nsg mice

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Cg-Rag1 (NSG) mice are a laboratory mouse model that lack mature T cells and B cells, making them immunodeficient. They are commonly used in biomedical research for studying engraftment of human cells and tissues.

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NSG mice (401 citations) Rag1−/− mice (182 citations)

2 protocols using cg rag1 nsg mice

Xenograft Model for MM Evaluation

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All animal work was performed according to the guidelines of the Institutional Animal Care and local veterinary office and ethics committee of the University of IOWA, USA (IACUC 1301010) under approved protocol. MM cells (1 × 10⁶) were subcutaneously xenografted into both flank of 6-8 weeks’ NOD. Cg-Rag1 (NSG) mice (Jackson laboratory, Bar Harbor, Maine) (n = 5). After 7 days, CGI-1746 (200 mg/kg, SC) treatment was started and injected daily. Tumor burdens were measured by tumor volume. Once tumors reached 20 mm in diameter, mice were sacrificed by CO₂ asphyxiation.

Gu C., Peng H., Lu Y., Yang H., Tian Z., Yin G., Zhang W., Lu S., Zhang Y, & Yang Y. (2017). BTK suppresses myeloma cellular senescence through activating AKT/P27/Rb signaling. Oncotarget, 8(34), 56858-56867.

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Bortezomib Treatment of Myeloma in NSG Mice

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MM cells (2 × 10⁶) were injected subcutaneously into the abdomen of 6-8 weeks′ NOD. Cg-Rag1 (NSG) mice (Jackson laboratory, Bar Harbor, Maine) (n = 5). After 10 days, Bortezomib (1 mg/kg, IP) treatment was started and injected twice per week. Tumor burdens were monitored by tumor volume. The mice were sacrificed by CO₂ asphyxiation when subcutaneous tumors reached 20 mm in diameter.

Gu C., Feng L., Peng H., Yang H., Feng Z, & Yang Y. (2015). MTDH is an oncogene in multiple myeloma, which is suppressed by Bortezomib treatment. Oncotarget, 7(4), 4559-4569.

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