Varian 3100 ftir spectrometer

The FTIR spectra of aniracetam, HP-β-CD, simple mixtures, and 1:1 inclusion complexes were obtained using a Varian 3100 FTIR spectrometer (Varian Inc., Palo Alto, CA, USA). All samples contained sucrose, as described above. Aniracetam, HP-β-CD, simple mixture, and inclusion complex samples were all ground and mixed thoroughly with potassium bromide (KBr) separately. Subsequent KBr disks were then prepared via compression of the mixed powder. The FTIR spectral range recorded was 500–4000 cm⁻¹ with 128 scans per sample and a resolution of 2 cm⁻¹, as seen in Mangolim et al. [28 (link)]. The resultant spectra were overlaid, and changes in peak assignments were recorded between constituent compounds and the inclusion complex.

Fourier Transform Infrared (FTIR) spectra were recorded by placing approximately 2 mg of the sample on the GladiATR accessory (Pike Technologies, Madison, USA) equipped in a Varian 3100 FTIR spectrometer (Varian Inc., California, CA, USA). The spectra were collected at a 4 cm⁻¹ resolution with 64 scans over a range of 400–4000 cm⁻¹ using Resolution Pro software (Agilent Technologies Inc., California, CA, USA). Peak positions were also identified using the same software.