For patients on apixaban, rivaroxaban, and LMWH, the estimated concentrations or the anti‐Xa activity have been measured using the STA‐Liquid Anti‐Xa (Diagnostica Stago) and the corresponding calibrators and controls according to the recommendations of the manufacturer on an STA‐R Max analyzer (Diagnostica Stago). For dabigatran samples, the estimated dabigatran plasma concentrations have been measured using the STA‐ECA II (Diagnostica Stago) with the corresponding calibrators and controls. For VKA patients, the INRs have been measured with the STA–Neoplastine R (Diagnostica Stago) according to the recommendations of the manufacturer. For healthy individuals, the prothrombin time (PT) and the activated partial thromboplastin time (aPTT) have been assessed using the STA–Neoplastine R (Diagnostica Stago) and the STA‐C.K. Prest (Diagnostica Stago) according to the recommendations of the manufacturer.
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