Midazolam mdz

Manufactured by Merck Group

Sourced in United States

Midazolam (MDZ) is a short-acting benzodiazepine used as a sedative, hypnotic, anxiolytic, muscle relaxant, and anticonvulsant. It is commonly used in medical procedures, such as anesthesia induction, procedural sedation, and the management of seizures.

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Lab products found in correlation

Methyl t butyl ether, by Thermo Fisher Scientific (1 mentions) Sodium hydroxide (naoh), by Thermo Fisher Scientific (1 mentions) Methanol, by Thermo Fisher Scientific (1 mentions) Ammonium acetate, by Merck Group (1 mentions) 1 oh midazolam, by Merck Group (1 mentions) 4 oh midazolam, by Merck Group (1 mentions) Formic acid, by Thermo Fisher Scientific (1 mentions) Acetonitrile, by Thermo Fisher Scientific (1 mentions) Phosphate buffered saline (pbs), by Research Products International (1 mentions)

Spelling variants of this product

Midazolam (72 citations) 1′-hydroxy-midazolam (1′-OH-MDZ), (3 citations)

2 protocols using midazolam mdz

Quantification of Midazolam Metabolites

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Midazolam (MDZ), 1’-OH-midazolam, 4’-OH-midazolam, and lorazepam (LZP) reference standards and ammonium acetate were purchased from Sigma-Aldrich (St. Louis, MO). Methanol, sodium hydroxide, and methyl-t-butyl-ether (MTBE) was purchased from Fisher Scientific (Pittsburgh, PA). Drug-free Balb-C mouse plasma was provided by Innovative Research (Novi, MI). All water used was ultrafiltered (Millipore).

Nicoli E.R., Al Eisa N., Cluzeau C.V., Wassif C.A., Gray J., Burkert K.R., Smith D.A., Morris L., Cologna S.M., Peer C.J., Sissung T.M., Uscatu C.D., Figg W.D., Pavan W.J., Vite C.H., Porter F.D, & Platt F.M. (2016). Defective Cytochrome P450-Catalysed Drug Metabolism in Niemann-Pick Type C Disease. PLoS ONE, 11(3), e0152007.

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Quantification of Efavirenz Metabolism

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Efavirenz (EFV) was purchased from TCI America lnc. (Portland, OR, USA). Chlorzoxazone (CHZ), 6-OH-CHZ, 7-ethoxyresorufin (7-ER), and nicotinamide adenine dinucleotide phosphate (NADPH) were obtained from Cayman Chemical (Ann Arbor, MI, USA). Midazolam (MDZ) and resorufin (RSF) were purchased from Sigma–Aldrich, lnc. (St. Louis, MO, USA). Formic acid and acetonitrile were purchased from Fisher Scientific Co. (Pittsburgh, PA, USA). Phosphate-buffered saline (PBS) was obtained from Research Products International Corp. (Mount Prospect, IL, USA).

Wang P., Shao X., Bao Y., Zhu J., Chen L., Zhang L., Ma X, & Zhong X.B. (2019). Impact of obese levels on the hepatic expression of nuclear receptors and drug-metabolizing enzymes in adult and offspring mice. Acta Pharmaceutica Sinica. B, 10(1), 171-185.

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