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Bcl6 cd4 cre mice

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The Bcl6+/+;Cd4-Cre+ mice are a genetically engineered mouse model. They express the Cre recombinase under the control of the Cd4 promoter, allowing for the deletion of the Bcl6 gene in T cells.

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Lab products found in correlation

Bcl6fl fl cd4 cre0 mice, by Jackson ImmunoResearch (2 mentions) Female c57bl 6 b6 mice, by Charles River Laboratories (2 mentions) Il 21r mice, by Jackson ImmunoResearch (2 mentions)

Spelling variants of this product

Cd4-Cre (117 citations) CD4-Cre mice (66 citations) CD4−/− mice (6 citations)

2 protocols using bcl6 cd4 cre mice

1

Conditional Knockout Mice for Bcl6 and IL-21R

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Female C57BL/6 (B6) mice were purchased from Charles River Laboratories (Bethesda, MD). Bcl6+/+;Cd4-Cre+ mice, Bcl6fl/fl;Cd4-Cre0 mice, and IL-21R−/− mice were purchased from The Jackson Laboratory (Bar Harbor, ME). Bcl6+/+;Cd4-Cre+ mice and Bcl6fl/fl; Cd4-Cre0 mice were bred for two generations to obtain Bcl6fl/fl; Cd4-Cre+ mice that lacked Bcl-6 expression in CD4+ cells and are referred to in the article as “ablated mice.” Littermates (Bcl6+/+; Cd4-Cre)+ that lacked floxed Bcl-6 but expressed Cre recombinase and those that expressed the floxed allele but lacked Cre expression (Bcl6fl/fl;Cd4-Cre0) were used as controls. Genotyping was carried out according to the protocol provided by The Jackson Laboratory for mouse stock numbers 023727 (Bcl6fl/fl) and 022071 (Cd4-Cre+). Validation of genotype and phenotype was as reported by us previously (13 (link)).
Lang G.A., Amani S.A., Quinn J.L., Axtell R.C, & Lang M.L. (2019). Immunization-Expanded NKT Follicular Helper Cells Drive IgG1 Isotype Switch against an Exogenous T-Independent Polysaccharide but Do Not Promote Recall Responses. ImmunoHorizons, 3(3), 88-93.
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2

Conditional Knockout Mice for Bcl6 and IL-21R

Check if the same lab product or an alternative is used in the 5 most similar protocols
Female C57BL/6 (B6) mice were purchased from Charles River Laboratories (Bethesda, MD). Bcl6+/+;Cd4-Cre+ mice, Bcl6fl/fl;Cd4-Cre0 mice, and IL-21R−/− mice were purchased from The Jackson Laboratory (Bar Harbor, ME). Bcl6+/+;Cd4-Cre+ mice and Bcl6fl/fl; Cd4-Cre0 mice were bred for two generations to obtain Bcl6fl/fl; Cd4-Cre+ mice that lacked Bcl-6 expression in CD4+ cells and are referred to in the article as “ablated mice.” Littermates (Bcl6+/+; Cd4-Cre)+ that lacked floxed Bcl-6 but expressed Cre recombinase and those that expressed the floxed allele but lacked Cre expression (Bcl6fl/fl;Cd4-Cre0) were used as controls. Genotyping was carried out according to the protocol provided by The Jackson Laboratory for mouse stock numbers 023727 (Bcl6fl/fl) and 022071 (Cd4-Cre+). Validation of genotype and phenotype was as reported by us previously (13 (link)).
Lang G.A., Amani S.A., Quinn J.L., Axtell R.C, & Lang M.L. (2019). Immunization-Expanded NKT Follicular Helper Cells Drive IgG1 Isotype Switch against an Exogenous T-Independent Polysaccharide but Do Not Promote Recall Responses. ImmunoHorizons, 3(3), 88-93.
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