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Sr11237

Manufactured by Merck Group
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Sourced in United Kingdom, Canada, United States

The SR11237 is a laboratory equipment product designed for general scientific applications. It serves as a basic instrument for various experimental and analytical tasks. The core function of this product is to provide a controlled and reliable platform for conducting laboratory procedures. Further details on the specific intended uses or capabilities of this equipment are not available.

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Lab products found in correlation

Dimethyl sulfoxide (dmso), by Merck Group (2 mentions) Am580, by Merck Group (1 mentions) Cd3254, by Bio-Techne (1 mentions) Ttnpb, by Bio-Techne (1 mentions) 9 cis retinoic acid, by Merck Group (1 mentions) Retinol, by Merck Group (1 mentions) Ds u2, by Nikon (1 mentions) 3 isobutyl 1 methylxanthine ibmx, by Cyagen (1 mentions) Dexamethasone (dex), by Cyagen (1 mentions) Hbmsc, by Cyagen (1 mentions) Rosiglitazone, by Cyagen (1 mentions) Sc 97, by Selleck Chemicals (1 mentions) Z vad fmk, by Selleck Chemicals (1 mentions) Mk 2206, by Selleck Chemicals (1 mentions)

5 protocols using sr11237

1

Novel Retinoid Compounds Synthesis

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ATRA, retinol, 9‐cis‐retinoic acid, AM580, AM80, and SR11237 were purchased from Sigma‐Aldrich, St. Louis, MO. CD 3254, TTNPB, and EC23 were purchased from Tocris Bioscience, Bristol, U.K. AGN193312 was synthesized over two steps (see Supporting Information). The synthesis of AGN194301 has been described previously.30
Drowley L., McPheat J., Nordqvist A., Peel S., Karlsson U., Martinsson S., Müllers E., Dellsén A., Knight S., Barrett I., Sánchez J., Magnusson B., Greber B., Wang Q, & Plowright A.T. (2019). Discovery of retinoic acid receptor agonists as proliferators of cardiac progenitor cells through a phenotypic screening approach. Stem Cells Translational Medicine, 9(1), 47-60.
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2

Newt Tail Regeneration Assay

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Following amputation, animals were maintained in dechlorinated water containing either 1 × 10–6 M SR11237 (RXR pan-agonist, Sigma), 1 × 10–6 M LE135 (RARβ antagonist, Tocris, (Bristol, UK), or 0.01% DMSO (vehicle control). For SR11237 and DMSO-treated samples, newt tail regenerates were imaged at 7, 14, and 21 dpa under a dissecting microscope, using a Nikon DS-U2 camera equipped with NIS Elements software. At 21 dpa, SR11237 (n = 7), LE135 (n = 3) and DMSO (n = 7) regenerates were collected and flash frozen on liquid nitrogen for western blot analysis.
Walker S.E., Nottrodt R., Maddalena L., Carter C., Spencer G.E, & Carlone R.L. (2018). Retinoid X receptor α downregulation is required for tail and caudal spinal cord regeneration in the adult newt. Neural Regeneration Research, 13(6), 1036-1045.
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3

Investigating Bone Development in Rat Pups

Cited 1 time
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In each trial, Sprague-Dawley rat pups were divided randomly into two groups. The first group was given an intraperitoneal injection (IP) of SR11237 (Sigma, Oakville, ON, Canada, #S8951) (pan-RXR specific agonist) at a concentration of 25 mg per kg body weight (dissolved in DMSO). The second group was injected with the same volume of DMSO (dimethyl sulfoxide) (Sigma, Oakville, ON, Canada, #472301) vehicle. Neonates were injected IP once a day from post-natal day 5 to post-natal day 15, in a similar regime as published for GLP (glucagon-like peptide) agonists in newborns [27 (link)], during a critical window of bone development in the rat [1 (link),5 (link),10 (link),11 (link),12 (link)]. This dose of SR11237 is similar to the one previously used in vivo [28 (link)]. The animals were harvested on post-natal day 16. The animals were weighed at time of harvest.
Dupuis H., Pest M.A., Hadzic E., Vo T.X., Hardy D.B, & Beier F. (2019). Exposure to the RXR Agonist SR11237 in Early Life Causes Disturbed Skeletal Morphogenesis in a Rat Model. International Journal of Molecular Sciences, 20(20), 5198.
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4

Adipogenic Differentiation of hBMSCs and SW872 Cells

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hBMSCs (Cyagen Biosciences, Guanzhou, China) and human liposarcoma SW872 cell line (ATCC, Rockville, MD, USA) were cultured in modified Eagle’s medium (MEM) containing 10% (v/v) fetal bovine serum (FBS), 100 units/mL penicillin, 0.1 mg/mL streptomycin, and 2 mM l-glutamine at 37 °C under a humidified, 5% CO2 atmosphere. Culture medium was changed every 2–3 days. When the cells were 100% confluent, they were induced to differentiate into adipocytes with adipogenic differentiation medium containing Human Mesenchymal Stem Cell Adipogenic Differentiation Basal Medium A, Mesenchymal Stem Cell-Qualified Fetal Bovine Serum (10%), glutamine (2 mM), penicillin (100 units /mL), streptomycin (0.1 mg/mL), insulin (10μg/mL), 3-isobutyl-1-methylxanthine (IBMX) (500 μM), rosiglitazone (0.5 μM), and dexamethasone (1 μM) (Cyagen Biosciences, Guanzhou, China). ATRA, 9CRA, 4-[(1E)-2-(5,5,8,8-tetramethyl-5,6,7,8- tetrahydro-2-naphthalenyl)-1-propen-1-yl] benzoic acid (TTNPB), and SR11237 (Sigma-Aldrich, St. Louis, MO, USA) was dissolved in dimethyl sulfoxide (DMSO) for the experiments. The cells were cultured under dim light when treated with retinoids to prevent their degradation.
Cao J., Ma Y., Yao W., Zhang X, & Wu D. (2017). Retinoids Regulate Adipogenesis Involving the TGFβ/SMAD and Wnt/β-Catenin Pathways in Human Bone Marrow Mesenchymal Stem Cells. International Journal of Molecular Sciences, 18(4), 842.
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5

Zebrafish Embryo Chemical Screening

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Zebrafish embryos at 2 dpf were soaked in egg water containing chemicals for 2 days, and relevant experiments were performed at 4 dpf. DMSO (Sigma‒Aldrich #D8418), sulindac (Selleck #S2007, 20 μM), SR11237 (Sigma‒Aldrich #S8951, 1 μM), CD3254 (MCE #HY-107399, 1 μM), 3-methyladenine (MCE, #HY-19312, 1 mM), Z-VAD-FMK (Selleck #S7023, 100 μM), dmPGE2 (Apexbio #B7568, 10 μM), MHY1485 (MCE #HY-B0795, 5 μM), SC97 (Selleck #S7863, 1 μM) and MK-2206 (Selleck #S1078, 30 μM) were used in this study.
Sun W., Wang M., Zhao J., Zhao S., Zhu W., Wu X., Li F., Liu W., Wang Z., Gao M., Zhang Y., Xu J., Zhang M., Wang Q., Wen Z., Shen J., Zhang W, & Huang Z. (2023). Sulindac selectively induces autophagic apoptosis of GABAergic neurons and alters motor behaviour in zebrafish. Nature Communications, 14, 5351.
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