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Dxc 600 pro

Manufactured by Beckman Coulter
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Sourced in United States

The DXC 600 Pro is an automated clinical chemistry and immunoassay analyzer developed by Beckman Coulter. It is designed to perform a wide range of diagnostic tests in clinical laboratories, including tests for chemistry, immunoassay, and specialized assays. The DXC 600 Pro offers high-throughput capabilities and advanced technology to deliver accurate and reliable results.

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Lab products found in correlation

Immulite 2000, by Siemens (4 mentions) Immulite 2000 xpi, by Siemens (3 mentions) Vacutainer, by BD (1 mentions) Milliplex map, by Merck Group (1 mentions) Qdr 4500a, by Hologic (1 mentions) Rd191108200r, by BioVendor (1 mentions) Mouse lps elisa kit, by Cusabio (1 mentions)

15 protocols using dxc 600 pro

1

Metabolic Biomarker Profiling Protocol

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Serum blood was collected for measurement of glucose (DXC 600 Pro; Beckman Coulter), insulin (Immulite 2000 XPi; Siemens), FFA (DXC 600 Pro; Beckman Coulter; reagent kit from Wako), C-peptide (Immulite 2000 XPi; Siemens), FSH (Immulite 2000 XPi; Siemens), and lipids (DXC 600 Pro; Beckman Coulter). Urine collected during clamp testing (day 5) was assayed for nitrogen by pyrochemiluminescence on an Antek 9000 Series Nitrogen & Sulfur Analyzer (Antek Instruments, Inc.; Houston, TX).
Bae Y.S, & Knudsen G.R. (2000). Cotransformation of Trichoderma harzianum with β-Glucuronidase and Green Fluorescent Protein Genes Provides a Useful Tool for Monitoring Fungal Growth and Activity in Natural Soils. Applied and Environmental Microbiology, 66(2), 810-815.
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2

Metabolic and Inflammatory Biomarker Panel

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Fasting glucose (DXC 600 Pro; Beckman Coulter), estradiol and FSH (Immulite 2000 XPi; Siemens), and lipids (DXC 600 Pro; Beckman Coulter) were measured at screening. Markers of inflammation were measured in serum via ELISA, including: fibroblast growth factor 21 (FGF21) (24 ); leptin, plasminogen activator inhibitor-1 (PAI-1), retinol binding protein 4 (RBP4), and Lipocalin 2 (LCN2) (25 –28 ); adiponectin (29 ); C-reactive protein (CRP) (30 ); Gla-type and Glu-type Osteocalcin (Gla-OC and Glu-OC) (31 ,32 ); and Intact Osteocalcin (Intact-OC) (33 ). Quantitative determination of thiobarbituric acid reactive substances (TBARS) was done using a TBARS assay kit.
Marlatt K.L., Lovre D., Beyl R.A., Tate C.R., Hayes E.K., Burant C.F., Ravussin E, & Mauvais-Jarvis F. (2020). Effect of conjugated estrogens and bazedoxifene on glucose, energy and lipid metabolism in obese postmenopausal women. European journal of endocrinology, 183(4), 439-452.
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3

Circadian Rhythm and Testosterone Dynamics

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Fasted blood samples were collected on days 0, 14, 42, and 56 between 06:00 h and 09:00 h to limit the potential confounding effects of circadian rhythm on total testosterone in young men [17 (link)]. Blood samples were analysed for total testosterone, follicle-stimulating hormone, estradiol, sex hormone-binding globulin, luteinising hormone, insulin, cortisol, and prostate-specific antigen (Siemens Immulite 2000, Llanberis, UK). Free testosterone was determined by calculation [18 (link)]. Insulin-like growth factor-1 was analysed using an enzyme-linked immunoassay (ALPCO, Salem, NH). Glucose, total cholesterol, HDL-cholesterol, triglycerides, and alanine aminotransferase were analysed on a Beckman DXC 600 Pro (Brea, CA). LDL-cholesterol was determined by calculation [19 (link)]. Complete blood counts were analysed on a Beckman DxH (Brea, CA). Systolic and diastolic blood pressure were measured manually on days 0, 15 (prior to the first treatment injection), and 42.
Pasiakos S.M., Berryman C.E., Karl J.P., Lieberman H.R., Orr J.S., Margolis L.M., Caldwell J.A., Young A.J., Montano M.A., Evans W.J., Vartanian O., Carmichael O.T., Gadde K.M., Johannsen N.M., Beyl R.A., Harris M.N, & Rood J.C. (2019). Effects of testosterone supplementation on body composition and lower-body muscle function during severe exercise- and diet-induced energy deficit: A proof-of-concept, single centre, randomised, double-blind, controlled trial. EBioMedicine, 46, 411-422.
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4

Blood Biomarkers Post-Exercise Analysis

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Blood samples, with the exception of 3‐h post exercise (PE) for study 1, were collected after an overnight fast by antecubital venipuncture (Vacutainer; Becton Dickson, Franklin Lakes, NJ). Serum was isolated, frozen, and shipped on dry ice to the Pennington Biomedical Research Center (Baton Rouge, LA) for analysis of CK (Beckman Coulter DXC 600 Pro, Beckman Coulter, Brea CA), IL‐6 (Milliplex MAP; Millipore, Billerica, MA), hepcidin (DRG International, Inc, Springfield, NJ) and ferritin (Siemens Medical Solutions USA Inc, Malvern, PA).
Pasiakos S.M., Margolis L.M., Murphy N.E., McClung H.L., Martini S., Gundersen Y., Castellani J.W., Karl J.P., Teien H.K., Madslien E.H., Stenberg P.H., Young A.J., Montain S.J, & McClung J.P. (2016). Effects of exercise mode, energy, and macronutrient interventions on inflammation during military training. Physiological Reports, 4(11), e12820.
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5

Metabolic Responses to Carbohydrate Intake

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Serum glucose, free-fatty acids, glycerol, and plasma lactate concentrations were determined using enzymatic and colorimetric measurements (Beckman Coulter DXC 600 Pro, Beckman Coulter, Brea, CA, United States). Serum insulin concentrations were determined using an advanced automated immunoassay instrument (Immulite® 2000: Siemens Healthcare Diagnostic, Deerfield, IL, United States). Glucose and insulin concentrations measured in the blood sample before the participants ingested the initial bolus of carbohydrate or placebo beverages and began exercising were used to calculate homeostasis model assessment of insulin resistance (HOMA-IR). Total urine volume produced during the timed collection was measured, and aliquots were frozen and stored at -20°C until analyzed. Nitrogen concentration of the urine was determined in triplicate using pyrochemiluminescence (Antek 9000, Houston, TX, United States), and nitrogen excretion was calculated by multiplying nitrogen concentration by volume of urine produced divided by collection duration.
Young A.J., Berryman C.E., Kenefick R.W., Derosier A.N., Margolis L.M., Wilson M.A., Carrigan C.T., Murphy N.E., Carbone J.W., Rood J.C, & Pasiakos S.M. (2018). Altitude Acclimatization Alleviates the Hypoxia-Induced Suppression of Exogenous Glucose Oxidation During Steady-State Aerobic Exercise. Frontiers in Physiology, 9, 830.
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6

Serum Glucose and Insulin Analysis

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Serum glucose concentration was measured by the glucose oxidase method on a Beckman Coulter DXC 600 Pro. Insulin and C-peptide concentrations were analyzed using immunoassays on a Siemen's Immulite 2000 instrument.
Galgani J.E., Mizgier M.L., Mari A, & Ravussin E. (2014). Relationship between whole-body macronutrient oxidative partitioning and pancreatic insulin secretion/β-cell function in non-diabetic humans. Metabolism: clinical and experimental, 63(11), 1426-1431.
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7

High-Altitude Acclimation Blood Measures

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Blood samples were collected at SL (SL day 6), and on the 2nd, 7th, 13th and 19th full day of residence at 4300 m (HA2, HA7, HA13, and HA19, respectively). All blood samples were obtained by venipuncture after ≥ 20 min of seated rest, and following a >10 h fast. Hct and Hb concentrations were determined using an automated analyzer (i‐STAT™, Abbott Point of Care Inc., Princeton, NJ). Serum protein and osmolality were determined using an automated analyzer (Beckman Coulter DXC 600 Pro, Brea, CA), with osmolality calculated from sodium (Na), glucose (glu) and blood urea nitrogen (BUN) concentrations [Osm = (1.86*Na) + (Glu/18) + (BUN/2.8) + 9] (Dorwart and Chalmers 1975).
Young A.J., Karl J.P., Berryman C.E., Montain S.J., Beidleman B.A, & Pasiakos S.M. (2019). Variability in human plasma volume responses during high‐altitude sojourn. Physiological Reports, 7(6), e14051.
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8

Metabolism and Biomarker Analyses

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Glucose sampled from the OGTT was determined using whole blood on a Beckman Coulter chemistry analyzer system (DXC 600 Pro). Serum insulin was determined by immunoassay (Immulite; Siemens Healthcare). HbA1c, lipids, and renal function were determined on an automated diagnostic platform.
Zunica E.R., Heintz E.C., Dantas W.S., Hebert R.C., Tanksley M., Beyl R.A., Mader EC J.r., Kirwan J.P., Axelrod C.L, & Singh P. (2024). Effects of metformin on glucose metabolism and mitochondrial function in patients with obstructive sleep apnea: A pilot randomized trial. Physiological Reports, 12(3), e15948.
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9

Fasted Plasma Biomarker Profiling

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Animals were fasted overnight and trunk blood was collected immediately after euthanization. Samples were collected in tubes with EDTA and plasma was aliquotted into cryovials and stored at −80 °C for analysis. Insulin, leptin, resistin, interleukin-1 beta (IL-1β) and tumor necrosis factor alpha (TNFα) were measured using a multiplex assay (Millipore, Temecula, CA) measured on a Luminex 200 (Luminex, Austin, TX). Total cholesterol and triglycerides (TG) were assayed on a DxC 600 Pro (Beckman Coulter, Inc., Indianapolis IN).
Waterman C., Rojas-Silva P., Tumer T.B., Kuhn P., Richard A.J., Wicks S., Stephens J.M., Wang Z., Mynatt R., Cefalu W, & Raskin I. (2015). Isothiocyanate-rich Moringa oleifera extract reduces weight gain, insulin resistance and hepatic gluconeogenesis in mice. Molecular nutrition & food research, 59(6), 1013-1024.
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10

Anthropometric Measurements and Body Composition

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Hemoglobin A1c was obtained by venipuncture after a 10-h fast and analyzed with a Beckman Coulter DXC600 Pro (Brea, CA). Weight was measured on a GSE 450 electronic scale (GSE Scale Systems, Novi, Michigan) and height was measured using a standard stadiometer. Body mass index (BMI) was calculated as follow: body weight (kg)/height (m2). Waist circumference was measured to the nearest 0.1 cm at the level of the iliac crest while the subject was at minimal expiration. Body composition was measured by dual-energy x-ray absorptiometry using the QDR 4500A whole-body scanner (Hologic Inc., Bedford, MA).
Earnest C.P., Johannsen N.M., Swift D.L., Gillison F.B., Mikus C.R., Lucia A., Kramer K., Lavie C.J, & Church T.S. (2014). Aerobic and Strength Training in Concomitant Metabolic Syndrome and Type 2 Diabetes. Medicine and science in sports and exercise, 46(7), 1293-1301.
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