The chemical library was donated by the EPA ToxCast Program. For verification and replication experiments, the following chemicals were purchased from Sigma-Aldrich: DL -α tocopherol acetate (T3376), DL -sulforophane (S4441), vincristine sulfate salt (V8879), oxyfluorfen (35031), rotenone (45656), fenamidone (33965), pyraclostrobin (33696), trifloxystrobin (46447), myxothiazol (T5580), pyridaben (46047), azoxystrobin (31697), fluoxastrobin (33797), fenpyroximate (31684) and kresoxim-methyl (37899). Famoxadone was purchased from Chem Service, Inc (N-11943). Topotecan hydrochloride was purchased from Tocris (4562). Paclitaxel was purchased from Fisher Scientific (AC32842). All chemical stocks were prepared in DMSO unless otherwise noted. Vehicle samples were prepared with an equivalent DMSO concentration of ≤0.5% in feeding medium.
Kresoxim methyl
Manufactured by Merck Group
Sourced in Germany
Kresoxim-methyl is a strobilurin fungicide developed by Bayer CropScience. It is a synthetic compound that inhibits mitochondrial respiration in fungi, thereby preventing their growth and reproduction. Kresoxim-methyl is primarily used as a fungicide in agricultural applications to control various fungal diseases in crops.
Automatically generated - may contain errors
Lab products found in correlation
Azoxystrobin, by Merck Group (3 mentions)
Psa bulk powder, by Agilent Technologies (2 mentions)
D spe, by Agilent Technologies (2 mentions)
Cyproxonazole, by Merck Group (2 mentions)
Anhydrous sodium sulfate, by Biopack (2 mentions)
Sodium citrate dihydrate, by Merck Group (2 mentions)
Sodium chloride (nacl), by Biopack (2 mentions)
Epoxiconazole, by Merck Group (2 mentions)
Deltamethrin, by Merck Group (2 mentions)
Penconazole, by Merck Group (2 mentions)
Sodium hydrogencitrate sesquihydrate, by Merck Group (2 mentions)
Rotenone, by Merck Group (1 mentions)
Dl α tocopherol acetate, by Merck Group (1 mentions)
Topotecan hydrochloride, by Bio-Techne (1 mentions)
Vincristine sulfate salt, by Merck Group (1 mentions)
Oxyfluorfen, by Merck Group (1 mentions)
Paclitaxel, by Thermo Fisher Scientific (1 mentions)
Pyraclostrobin, by Merck Group (1 mentions)
Trifloxystrobin, by Merck Group (1 mentions)
Myxothiazol, by Merck Group (1 mentions)
4 protocols using kresoxim methyl
1
Chemical Library Acquisition and Verification
2
Antifungal Compounds Assessment Protocol
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Antifungal compounds, kresoxim methyl (Kre-Me; strobilurin), octylgallate (octyl 3,4,5-trihydroxybenzoic acid; OG), veratraldehyde (3,4-dimethoxybenzaldehyde; VT), benzohydroxamic acid (BHAM) (Figure 1 ), were procured from Sigma Co. (St. Louis, MO, USA). Each compound was dissolved in dimethylsulfoxide (DMSO; absolute DMSO amount: <2% in media) before incorporation into culture media (except for those plates used in aflatoxin assays; see below). Throughout this study, control plates (No treatment) contained DMSO at levels equivalent to that of cohorts receiving antifungal agents, within the same set of experiments.
3
Pesticides Analysis in Samples
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The pesticides standards of deltamethrin, penconazole, kresoxim-methyl, cyproxonazole, epoxiconazole and azoxystrobin were supplied by Sigma-Aldrich (Seelze, Germany). The stock solutions (1000 mg/L) were prepared by dissolving the standards in methanol HPLC grade (99.9%) purchased by Sintorgan (Buenos Aires, Argentina), and stored under freezing condition (-18°C ± 1°C) in dark bottles sealed with PTFE/silicone caps. The working standard solutions (50 mg/L) were prepared in acetonitrile (ACN) of high purity grade for residue analysis, provided by Merck (Darmstadt, Germany).
Deionized water obtained from an E-pure water purification system (Barnstead/Thermolyne, Bedford, MA, United States) was used for sample swelling in the extraction step.
For extraction and partitioning, sodium chloride and anhydrous sodium sulfate were purchased from Biopack (Buenos Aires, Argentina); sodium hydrogencitrate sesquihydrate and sodium citrate dihydrate were obtained from Sigma-Aldrich (Seelze, Germany). For clean-up using d-SPE, C18 and PSA bulk powder were obtained from Agilent Technologies (Santa Clara, United States).
Deionized water obtained from an E-pure water purification system (Barnstead/Thermolyne, Bedford, MA, United States) was used for sample swelling in the extraction step.
For extraction and partitioning, sodium chloride and anhydrous sodium sulfate were purchased from Biopack (Buenos Aires, Argentina); sodium hydrogencitrate sesquihydrate and sodium citrate dihydrate were obtained from Sigma-Aldrich (Seelze, Germany). For clean-up using d-SPE, C18 and PSA bulk powder were obtained from Agilent Technologies (Santa Clara, United States).
4
Pesticides Analysis in Samples
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The pesticides standards of deltamethrin, penconazole, kresoxim-methyl, cyproxonazole, epoxiconazole and azoxystrobin were supplied by Sigma-Aldrich (Seelze, Germany). The stock solutions (1000 mg/L) were prepared by dissolving the standards in methanol HPLC grade (99.9%) purchased by Sintorgan (Buenos Aires, Argentina), and stored under freezing condition (-18°C ± 1°C) in dark bottles sealed with PTFE/silicone caps. The working standard solutions (50 mg/L) were prepared in acetonitrile (ACN) of high purity grade for residue analysis, provided by Merck (Darmstadt, Germany).
Deionized water obtained from an E-pure water purification system (Barnstead/Thermolyne, Bedford, MA, United States) was used for sample swelling in the extraction step.
For extraction and partitioning, sodium chloride and anhydrous sodium sulfate were purchased from Biopack (Buenos Aires, Argentina); sodium hydrogencitrate sesquihydrate and sodium citrate dihydrate were obtained from Sigma-Aldrich (Seelze, Germany). For clean-up using d-SPE, C18 and PSA bulk powder were obtained from Agilent Technologies (Santa Clara, United States).
Deionized water obtained from an E-pure water purification system (Barnstead/Thermolyne, Bedford, MA, United States) was used for sample swelling in the extraction step.
For extraction and partitioning, sodium chloride and anhydrous sodium sulfate were purchased from Biopack (Buenos Aires, Argentina); sodium hydrogencitrate sesquihydrate and sodium citrate dihydrate were obtained from Sigma-Aldrich (Seelze, Germany). For clean-up using d-SPE, C18 and PSA bulk powder were obtained from Agilent Technologies (Santa Clara, United States).
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