3 3 4 dihydroxyphenyl propanoic acid

Manufactured by Merck Group

Sourced in Spain

3-(3',4'-dihydroxyphenyl)propanoic acid is a chemical compound that can be used as a laboratory reagent. It has the chemical formula C₉H₁₀O₃. The compound contains a benzene ring with two hydroxyl groups and a propanoic acid group.

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Propanoic acid (18 citations)

4 protocols using 3 3 4 dihydroxyphenyl propanoic acid

Integrated Gut Microbiome Modulation

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Formic acid, bile salts, soluble starch, (+)-arabinogalactan, tryptone, yeast extract, xylan from birchwood, L-cysteine hydrochloride monohydrate, guar gum, inulin, Tween 80, buffered peptone water, Dulbecco′s phosphate buffer saline (PBS), casein sodium salt from bovine milk, pectin from citrus fruits, mucin from porcine stomach-type III, CaCl₂, KCl, NaCl, NaHCO₃, anhydrous K₂HPO₄, KH₂PO₄, MgSO₄ monohydrate, FeSO₄ heptahydrate, resazurin redox indicator, quercetin, kaempferol, quercetin-3-O-rutinoside (aka rutin), phenylacetic acid, 4′-hydroxyphenylacetic acid, 3′-hydroxyphenylacetic acid, 3′,4′-dihydroxyphenylacetic acid, 3-phenylpropanoic acid, 3-(4′-hydroxyphenyl)propanoic acid, 3-(3′-hydroxyphenyl)propanoic acid, 3-(3′,4′-dihydroxyphenyl)propanoic acid (aka dihydrocaffeic acid), 4-hydroxybenzoic acid, 3-hydroxybenzoic acid, 3,4-dihydroxybenzoic acid (aka protocatechuic acid), and benzene-1,3,5-triol (aka phloroglucinol) were obtained from Sigma-Aldrich (St Louis, MO, USA). Isorhamnetin was from PhytoLab GmbH (Vestenbergsgreuth, Germany). All solvents and water were UHPLC-grade and were purchased from VWR International (Milan, Italy).

Di Pede G., Bresciani L., Calani L., Petrangolini G., Riva A., Allegrini P., Del Rio D, & Mena P. (2020). The Human Microbial Metabolism of Quercetin in Different Formulations: An In Vitro Evaluation. Foods, 9(8), 1121.

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Quantification of Polyphenol Metabolites

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Ascorbic, 5-caffeoylquinic acid, 3′,4′-dihydroxycinnamic acid, 4′-hydroxy-3′-methoxycinnamic acid, 4′-hydroxycinnamic acid; hippuric acid, 3-(3′,4′-dihydroxyphenyl)propanoic acid, 3-(4′-hydroxy-3′-methoxyphenyl)propanoic acid, 3-(4′-hydroxyphenyl)propanoic acid, 3-(3′-hydroxyphenyl)propanoic acid, 3′,4′-dihydroxyphenylacetic acid, 4′-hydroxy-3′-methoxyphenylacetic acid, 4′-hydroxyphenylacetic acid, 3′-hydroxyphenylacetic acid, 3,4-dihydroxybenzoic acid, 4-hydroxy-3-methoxybenzoic acid, 4-hydroxybenzoic acid, and 3-hydroxybenzoic acid were purchased from Sigma-Aldrich (Madrid, Spain). 3,5-dicaffeoylquinic acid was purchased from PhytoLab (Vestenbergsgreuth, Germany). HPLC-grade solvents were acquired from Panreac (Madrid, Spain). Ultrapure water from MilliQ system (Millipore, Bedford, MA, USA) was used throughout the experiment.

Seguido M.Á., Tarradas R.M., González-Rámila S., García-Cordero J., Sarriá B., Bravo-Clemente L, & Mateos R. (2022). Sustained Consumption of a Decaffeinated Green Coffee Nutraceutical Has Limited Effects on Phenolic Metabolism and Bioavailability in Overweight/Obese Subjects. Nutrients, 14(12), 2445.

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Quantification of Phenolic Compounds

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Vanillic acid, isoVanillic acid, syringic acid, homoVanillic acid, caffeic acid, hippuric acid, p-coumaric acid, 3,4-dihydroxybenzoic acid, 2,5-dihydroxybenzoic acid, 2,4-dihydroxy benzoic acid, Vanillin, 4-hydroxybenzoic acid, 4-hydroxybenzaldehyde, sinapic acid, 3,5-dihydroxy benzoic acid, hydroferulic acid, ferulic acid, isoferulic acid, syringaldehyde, salicylic acid, 3,5-dichloro-4-hydroxybenzoic acid, 3-(3,4-dihydroxyphenyl)propanoic acid, 3,4-dihydroxyhydrocinnamic acid, o-coumaric acid, 2-hydroxyphenylacetic acid, 3-hydroxybenzaldehyde, 3-hydroxyphenylacetic acid, gallic acid, 3-hydroxybenzoic acid and 3,5-dichloro-4-hydroxybenzoic acid were obtained from Sigma–Aldrich (Gillingham, UK). Methanol, water, acetonitrile, and formic acid were all LC-MS grade and were obtained from Fisher Scientific (Loughborough, UK).

Costabile A., Corona G., Sarnsamak K., Atar-Zwillenberg D., Yit C., King A.J., Vauzour D., Barone M., Turroni S., Brigidi P, & Hauge-Evans A.C. (2022). Wholegrain fermentation affects gut microbiota composition, phenolic acid metabolism and pancreatic beta cell function in a rodent model of type 2 diabetes. Frontiers in Microbiology, 13, 1004679.

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Formulation of a Nutraceutical Blend

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B-Can™ 70% Oat Beta-Glucan purchased in Garuda International, Inc. (California, United States), and a decaffeinated phenol-rich (45%) green coffee extract acquired from Quimifarma Laboratorios S.L. (Toledo, Spain), were selected for the design of the nutraceutical. The mixture of 3.57 g BG and 0.66 g of GCPE (considering their purity) was flavoured (vanilla and chocolate) to increase its acceptability and was presented in single-dose sachets for dispersion in water (Quimifarma Laboratorios S.L. Toledo, Spain).
All solvents and reagents were of analytical grade unless otherwise stated. Ascorbic; 5caffeoylquinic acid; 3´,4´-dihydroxycinnamic acid; 4´-hydroxy-3´-methoxycinnamic acid; 4´hydroxycinnamic acid; hippuric acid; 3-(3´,4´-dihydroxyphenyl)propanoic acid; 3-(4´-hydroxy-3´methoxyphenyl)propanoic acid;
3-(4´-hydroxyphenyl)propanoic acid;
3-(3´hydroxyphenyl)propanonic acid; 3´,4´-dihydroxyphenylacetic acid; 4´-hydroxy-3´methoxyphenylacetic acid; 4´-hydroxyphenylacetic acid; 3´-hydroxyphenylacetic acid; 3,4dihydroxybenzoic acid; 4-hydroxy-3-methoxybenzoic acid; 4-hydroxybenzoic acid and 3hydroxybenzoic acid were from Sigma-Aldrich (Madrid, Spain). 3,5-dicaffeoylquinic acid was purchased from PhytoLab (Vestenbergsgreuth, Germany). Methanol, formic acid and acetonitrile (HPLC grade) were acquired from Panreac (Madrid, Spain).

Seguido M.Á., Tarradas R.M., González-Rámila S., García-Cordero J., Sarriá B., Bravo-Clemente L, & Mateos R. (2022). Influence of 8-week daily consumption of a new product combining green coffee hydroxycinnamates and beta-glucans on polyphenol bioavailability in subjects with overweight and obesity. Food & function, 13(3).

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