Tazobactam

Manufactured by Meilun

Sourced in China

Tazobactam is a beta-lactamase inhibitor. It is used in combination with certain antibiotics to enhance their effectiveness against bacteria that produce beta-lactamase enzymes.

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Lab products found in correlation

Aztreonam, by Merck Group (2 mentions) Avibactam, by MedChemExpress (2 mentions) Imipenem, by Merck Group (2 mentions) Amikacin, by Meilun (2 mentions) Probenecid, by Merck Group (1 mentions) Avibactam, by Meilun (1 mentions) Gentamicin, by Merck Group (1 mentions) Colistin, by Merck Group (1 mentions)

3 protocols using tazobactam

Antimicrobial Susceptibility Testing of E. coli and K. pneumoniae

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Antimicrobial susceptibility testing was performed and interpreted according to the Clinical and Laboratory Standards Institute (CLSI) guidelines and breakpoints (M100, 31st edition) by the agar dilution method. E. coli ATCC 25922 and K. pneumoniae ATCC 700603 served as control strains.
The antibiotics we used included meropenem (Hanhui Pharmaceutical Co., Ltd., China), imipenem (Merck Sharp & Dohme Corp., USA), cefepime (Jiangsu Hengrui Pharmaceutical Co., Ltd., China), piperacillin (Suzhou Erye Pharmaceutical Co., Ltd., China), ceftazidime (Guangdong Jincheng Jinsu Pharmaceutical Co., Ltd., China), tazobactam (Meilunbio, China), avibactam (MedChemExpress, USA), aztreonam (Sigma-Aldrich, USA), amikacin (Meilunbio), cefuroxime (Esseti Farmaceutici S.r.l., Italy), fosfomycin (Harbin Pharmaceutical Group Co., Ltd. China), levofloxacin (Daiichi Sankyo Company Limited, Beijing, China), and cefotaxime (North China Pharmaceutical Hebei Huamin Pharmaceutical Co., Ltd., China).

Zhou J., Wang W., Liang M., Yu Q., Cai S., Lei T., Jiang Y., Du X., Zhou Z, & Yu Y. (2023). A Novel CMY Variant Confers Transferable High-Level Resistance to Ceftazidime-Avibactam in Multidrug-Resistant Escherichia coli. Microbiology Spectrum, 11(2), e03349-22.

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Characterization of ESBL-producing Klebsiella

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Sodium salts of piperacillin, tazobactam, sulbactam and avibactam were all purchased from Dalian Meilun Biotech Co., Ltd. (Dalian, China). p-Aminohippuric acid (PAH), penicillin G (PCG) and probenecid were purchased from Sigma (USA). The strain of K. pneumonia producing extended spectrum β-lactamases (ESBLs) was a clinical isolate and was obtained from the first affiliated hospital of Dalian medical university. β-lactamase production was confirmed using polymerase chain reaction (PCR) and isoelectric focusing. Bacterial strains were stored at −70 °C as glycerol stocks. TEM-1 β-lactamase was purchased from Shanghai Aladdin Biochemical Technology Co. LTD. (Shanghai, China). All other chemical reagents were of analytical grade.

Yang S., Liu Z., Wang C., Wen S., Meng Q., Huo X., Sun H., Ma X., Peng J., He Z, & Liu K. (2018). Piperacillin enhances the inhibitory effect of tazobactam on β-lactamase through inhibition of organic anion transporter 1/3 in rats. Asian Journal of Pharmaceutical Sciences, 14(6), 677-686.

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Antimicrobial Susceptibility Testing of Pseudomonas aeruginosa

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Antimicrobial susceptibility testing of the isolated strains and cloning experimental strains was performed by the broth microdilution method. The antibiotics used included meropenem (Hanhui Pharmaceutical Co., Ltd., China), imipenem (Merck Sharp & Dohme Corp, USA), cefepime (Jiangsu Hengrui Pharmaceutical Co., Ltd., China), piperacillin (Suzhou Erye Pharmaceutical Co., Ltd. China), ceftazidime (Guangdong Jincheng Jinsu Pharmaceutical Co., Ltd., China), tazobactam (Meilunbio, China), avibactam (MedChemExpress, USA), aztreonam (Sigma-Aldrich, USA), ciprofloxacin (Fluka Analytical, USA), amikacin (Meilunbio, China), gentamicin (Sigma-Aldrich, USA), and colistin (Sigma-Aldrich, USA). The P. aeruginosa strain ATCC27853 was used for quality control. The results were interpreted according to CLSI performance standards (30^th Edition) (24 ).

Chen M., Cai H., Li Y., Wang N., Zhang P., Hua X., Yu Y, & Sun R. (2022). Plasmid-Borne AFM Alleles in Pseudomonas aeruginosa Clinical Isolates from China. Microbiology Spectrum, 10(5), e02035-22.

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