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Menopur

Manufactured by Merck Group

Menopur is a laboratory equipment product manufactured by Merck Group. It is a medication used to stimulate follicle development and ovulation in women undergoing fertility treatment. Menopur contains a combination of follicle-stimulating hormone (FSH) and luteinizing hormone (LH).

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3 protocols using menopur

1

IVF Protocol for Male Infertility

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Normo-ovulatory young women (< 37 years of age) undergoing IVF due to male factor infertility or genetic indication for pre-implantation genetic diagnosis were selected for this study. Subjects carrier of Fragile X disorder, endometriosis and polycystic ovary syndrome (PCOS) were excluded. Ovarian stimulation was carried out as previously described [32 (link)]. Briefly, short antagonist protocol was used, consisted of ovarian suppression with GnRH antagonists (0.25 mg/day, Cetrorelix, Cetrotide; Merck Serono International) and controlled ovarian hyperstimulation with human menopausal gonadotropin (HMG; Menopur) or recombinant FSH, either Gonal-F; Merck Serono or Puregon, MSD. The initial dose used was dependent upon age, body mass index, and previous IVF treatment history. When three or more follicles exceeded18 mm in diameter, 250 μg of hCG (Ovitrelle; Merck Serono) was administered to trigger ovulation. Transvaginal follicular aspiration was performed 36 h later with ultrasound guidance.
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2

IVF Protocol for Normo-ovulatory Young Women

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Normo-ovulatory young women (< 37 years of age) undergoing IVF because of male factor infertility or pre-implantation genetic diagnosis were selected for this study. Subjects a icted with BRCA mutations, Fragile X disorder, Endometriosis, or Polycystic Ovary Syndrome (PCOS) were excluded. Ovarian stimulation was carried out as previously described 54, (link)55 (link) . Brie y, a "short antagonist" protocol was used wherein controlled ovarian hyperstimulation with Human Menopausal Gonadotropins (HMG; Menopur®) or recombinant Follicle-Stimulating Hormone )rFSH, either Gonal-F®; Merck Serono or Puregon Pen®; Schering Plough) was initiated 3 days after the onset of menses. The initial gonadotropin dose used was dependent upon age, body mass index, and previous IVF treatment history. Ovarian suppression with a GnRH antagonist (0.25 mg/day, Cetrorelix, Cetrotide®; Serono International, SR) was initiated when the leading follicle was more than 12 mm in diameter. When three or more follicles exceeded18 mm in diameter, 250 µg of human Chorionic Gonadotropin (hCG; Ovitrelle®; Merck Serono) was administered to trigger ovulation. Transvaginal follicular aspiration was performed 36 hours later under ultrasound guidance.
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3

IVF Protocol for Normo-ovulatory Young Women

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Normo-ovulatory young women (< 37 years of age) undergoing IVF because of male factor infertility or pre-implantation genetic diagnosis were selected for this study. Subjects a icted with BRCA mutations, Fragile X disorder, Endometriosis, or Polycystic Ovary Syndrome (PCOS) were excluded. Ovarian stimulation was carried out as previously described 54, (link)55 (link) . Brie y, a "short antagonist" protocol was used wherein controlled ovarian hyperstimulation with Human Menopausal Gonadotropins (HMG; Menopur®) or recombinant Follicle-Stimulating Hormone )rFSH, either Gonal-F®; Merck Serono or Puregon Pen®; Schering Plough) was initiated 3 days after the onset of menses. The initial gonadotropin dose used was dependent upon age, body mass index, and previous IVF treatment history. Ovarian suppression with a GnRH antagonist (0.25 mg/day, Cetrorelix, Cetrotide®; Serono International, SR) was initiated when the leading follicle was more than 12 mm in diameter. When three or more follicles exceeded18 mm in diameter, 250 µg of human Chorionic Gonadotropin (hCG; Ovitrelle®; Merck Serono) was administered to trigger ovulation. Transvaginal follicular aspiration was performed 36 hours later under ultrasound guidance.
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