The studied compounds – two novel derivatives of pyrrolo[3,4-d]pyridazinone named 10b and 13b – were prepared and characterized as reported earlier.12 (link) Analysis of the 1H NMR, 13C NMR, MS, FT-IR, and elemental analysis as well as physicochemical features showed spectroscopic and analytical properties of the newly obtained derivatives to be in agreement with their assigned structure. Indomethacin, in subst. and λ-carrageenan, in subst. were purchased from Sigma Aldrich (Steinheim, Germany); carboxymethylcellulose (CMC), in subst. and formalin 37%, sol. were obtained from PolAura (Olsztyn, Poland); pentobarbital sodium + pentobarbital 133.3 mg/mL + 26.7 mg/mL, sol. was purchased from Biowet (Puławy, Poland); medetomidine hydrochloride 1 mg/mL, sol. was supplied from OrionPharma (Warszawa, Poland); normal saline was obtained from Polpharma (Starogard Gdański, Poland). Other chemicals used were included in the commercially available kits.
Carboxymethylcellulose cmc
Manufactured by Pol-Aura
Sourced in Germany, Poland
Carboxymethylcellulose (CMC) is a water-soluble cellulose derivative used as a thickening agent, emulsifier, and stabilizer in various industries. It is a white to off-white powder or granular material with a neutral pH.
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2 protocols using carboxymethylcellulose cmc
1
Synthesis and Characterization of Pyrrolo[3,4-d]pyridazinone Derivatives
2
Synthesis and Characterization of Novel Pyrrolo[3,4-d]pyridazinone Derivatives
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The studied compounds, novel pyrrolo[3,4-d]pyridazinone derivatives, named 10b and 13b , were synthesized from commercially available reagents and solvents according to the previously described method [6 (link)]. The structures and purity of 10b and 13b were confirmed by different spectroscopic techniques: 1H NMR, 13C NMR, MS, FTIR, elemental analysis, and on the basis of their physicochemical properties.
Drugs and chemicals used in the experiment were as follows: Indomethacin (Sigma-Aldrich, Steinheim, Germany); morphine hydrochloride (Fagron, Kraków, Poland); carboxymethylcellulose (CMC) (PolAura, Olsztyn, Poland) dissolved to 0.5% solution in normal saline (Polpharma, Starogard Gdański, Poland); pentobarbital sodium + pentobarbital 133.3 mg/mL + 26.7 mg/mL, sol. (Morbital, Biowet, Puławy, Poland); medetomidine hydrochloride 1 mg/mL, sol. (Domitor, OrionPharma, Warszawa, Poland); formalin 37% sol. (Chempur, Piekary Śląskie, Poland) dissolved to 1.5% solution in normal saline (as above). Other chemicals used were included in the commercially available kits.
Drugs and chemicals used in the experiment were as follows: Indomethacin (Sigma-Aldrich, Steinheim, Germany); morphine hydrochloride (Fagron, Kraków, Poland); carboxymethylcellulose (CMC) (PolAura, Olsztyn, Poland) dissolved to 0.5% solution in normal saline (Polpharma, Starogard Gdański, Poland); pentobarbital sodium + pentobarbital 133.3 mg/mL + 26.7 mg/mL, sol. (Morbital, Biowet, Puławy, Poland); medetomidine hydrochloride 1 mg/mL, sol. (Domitor, OrionPharma, Warszawa, Poland); formalin 37% sol. (Chempur, Piekary Śląskie, Poland) dissolved to 1.5% solution in normal saline (as above). Other chemicals used were included in the commercially available kits.
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