3 3 dimethyl 1 butanol dmb

Manufactured by Merck Group

Sourced in China

3,3-dimethyl-1-butanol (DMB) is a chemical compound used in laboratory settings. It is a clear, colorless liquid with a characteristic odor. DMB is commonly used as a solvent and as a starting material for the synthesis of other chemical compounds.

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Lab products found in correlation

P perk, by Cell Signaling Technology (1 mentions) Mouse lps elisa kit, by Cusabio (1 mentions) Neomycin, by MedChemExpress (1 mentions) Vancomycin hydrochloride, by MedChemExpress (1 mentions) Metronidazole, by MedChemExpress (1 mentions) Ampicillin, by MedChemExpress (1 mentions) Hs crp elisa kit, by Elabscience (1 mentions) Antibodies against perk, by Cell Signaling Technology (1 mentions) P eif2α, by Cell Signaling Technology (1 mentions) Standard chow diet, by Inotiv (1 mentions)

Spelling variants of this product

1-butanol (221 citations) Butanol (82 citations)

2 protocols using 3 3 dimethyl 1 butanol dmb

Gut Microbial Metabolite Regulation

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Ampicillin, metronidazole, neomycin, and vancomycin hydrochloride were purchased from MedChemExpress (Monmouth Junction, NJ, United States). Antibodies against PERK, p-PERK, and p-eIF2α were purchased from Cell Signaling (Danvers, MA, United States), and antibodies against eIF2α and β-tubulin were from Santa Cruz (Dallas, TX, United States). The enhanced chemiluminescence (ECL) kit was purchased from Thermo Fisher Scientific (Waltham, MA, United States). Mouse TMAO Elisa kit was purchased from Kisong Biotechnology (Beijing, China). Hs-CRP Elisa kit was purchased from Elabscience Biotechnology (Wuhan, China), mouse LPS Elisa kit from Cusabio (Wuhan, China), and 3,3-dimethyl-1-butanol (DMB) from Sigma-Aldrich (St. Louis, MO, United States).

Wang F., Gu Y., Xu C., Du K., Zhao C., Zhao Y, & Liu X. (2022). Transplantation of fecal microbiota from APP/PS1 mice and Alzheimer’s disease patients enhanced endoplasmic reticulum stress in the cerebral cortex of wild-type mice. Frontiers in Aging Neuroscience, 14, 858130.

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Dietary DMB Supplementation in Mice

Cited 1 time

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Young (3 months; N=12/group) and old (24 months; N=26-29/group; starting group sizes doubled to account for up to 50% attrition) mice were fed a standard chow diet (Envigo) and randomized to receive ad libitum access to either normal drinking water (Control) or drinking water supplemented with 1% (v/v) 3,3-dimethyl-1-butanol (DMB; Sigma-Aldrich) for 8-10 weeks^{14 (link)}. Mice were sacrificed at 5-6 (young) or 26-27 months (old) of age. All young mice survived the full intervention and were studied; N=20/group old mice survived and were studied.

Brunt V.E., Gioscia-Ryan R.A., Casso A.G., VanDongen N.S., Ziemba B.P., Sapinsley Z.J., Richey J.J., Zigler M.C., Neilson A.P., Davy K.P, & Seals D.R. (2020). Trimethylamine-N-Oxide Promotes Age-Related Vascular Oxidative Stress and Endothelial Dysfunction in Mice and Healthy Humans. Hypertension (Dallas, Tex. : 1979), 76(1), 101-112.

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