Star sc 166821

Manufactured by Santa Cruz Biotechnology

StAR (#sc-166821) is a steroidogenic acute regulatory protein that plays a crucial role in the regulation of steroid hormone biosynthesis. It facilitates the transport of cholesterol from the outer to the inner mitochondrial membrane, which is the rate-limiting step in the production of steroid hormones.

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Lab products found in correlation

α tubulin sc 23948, by Santa Cruz Biotechnology (1 mentions) Slug 9585, by Cell Signaling Technology (1 mentions) Resveratrol, by Merck Group (1 mentions) U0126, by Cayman Chemical (1 mentions) Sb431542, by Merck Group (1 mentions) Bone morphogenetic protein 4 (bmp4), by R&D Systems (1 mentions) Amphiregulin, by R&D Systems (1 mentions) Gdf 8, by R&D Systems (1 mentions) Recombinant human gdf11, by R&D Systems (1 mentions) Phospho akt 9271, by Cell Signaling Technology (1 mentions) Dorsomorphin, by Cayman Chemical (1 mentions)

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Sc-166821 (2 citations)

2 protocols using star sc 166821

Signaling Pathways in Cellular Processes

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The p-ERK1/2 (#9106), ERK1/2 (#9102), p-AKT (#9271), AKT (#9272), Snail (#3895), and Slug (#9585) antibodies were purchased from Cell Signaling Technology. The StAR (#sc-166821) and α-tubulin (#sc-23948) antibodies were purchased from Santa Cruz Biotechnology. The StAR anti-body only detects the mature form of StAR (30-kDa). The GPER (#ab154069) antibody was purchased from Abcam. The resveratrol was obtained from Sigma. The G-15 and U0126 were obtained from Cayman.

Song T., Chen J., Yang S., Liu B., Zhang L., Zhang Q., Cheng J.C, & Fang L. (2023). Resveratrol stimulates StAR expression and progesterone production by GPER-mediated downregulation of Snail expression in human granulosa cells. Journal of Food and Drug Analysis, 31(2), 315-325.

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TGF-β Signaling Pathway Profiling

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The StAR (#sc-166821) and α-tubulin (#sc-23948) antibodies were obtained from Santa Cruz Biotechnology. The ALK5 (#PA5-78198) antibody was obtained from Invitrogen. The phospho-SMAD1/5/8 (#13820), SMAD1 (#6944), phospho-SMAD2 (#3108), phospho-SMAD3 (#9520), SMAD2 (#3103), SMAD3 (#9523), SMAD4 (#38,454), phospho-ERK1/2 (#9106), ERK1/2 (#9102), phospho-AKT (#9271), and AKT (#9272) antibodies were obtained from Cell Signaling Technology. The recombinant human GDF-11, GDF-8, BMP-4, and amphiregulin were obtained from R&D Systems. SB431542, a potent ALK4, ALK5, and ALK7 inhibitor [20 (link)], was obtained from Sigma. Dorsomorphin and DMH-1 were obtained from Cayman.

Jia Q., Liu B., Dang X., Guo Y., Han X., Song T., Cheng J.C, & Fang L. (2022). Growth differentiation factor-11 downregulates steroidogenic acute regulatory protein expression through ALK5-mediated SMAD3 signaling pathway in human granulosa-lutein cells. Reproductive Biology and Endocrinology : RB&E, 20, 34.

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