Eupafolin (purity>99%) was kindly provided by Professor Horng-Huey Ko. 7-chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepin-2(3H)-one (CGP37157), DL-threo-β-benzyloxyaspartate (DL-TBOA), dantrolene, N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide (H89), and 1-[N,O-Bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazine (KN62) were purchased from Tocris (Bristol, UK). FM-43, 3,3,3-Dipropylthiadicarbocyanine iodide [DiSC3(5)], and fura-2-acetoxymethyl ester (Fura-2-AM) were purchased from Thermo (Waltham, MA, USA). ω-conotoxin GVIA (ω-CgTX GVIA) and ω-agatoxin IVA (ω-Aga IVA) were purchased from Alomone lab (Jerusalem, Israel). CaMKII, p-CaMKII, synapsin I and anti-rabbit IgG horseradish peroxidase-conjugated antibodies were obtained from Cell Signaling Technologies (Beverly, MA, USA). p-synapsin I (Serine 603) antibody was purchased from GeneTex (CA, USA). 4-aminopyridine (4-AP) and all other reagents were purchased from Sigma (St. Louis, MO, USA).
ω agatoxin iva ω aga iva
Manufactured by Alomone
Sourced in Israel
ω-agatoxin IVA (ω-Aga IVA) is a peptide isolated from the venom of the funnel-web spider Agelenopsis aperta. It is a potent and selective antagonist of P-type voltage-gated calcium channels.
Automatically generated - may contain errors
Lab products found in correlation
ω conotoxin gvia ω cgtx gvia, by Alomone (3 mentions)
Fura 2 acetoxymethyl ester fura 2 am, by Thermo Fisher Scientific (2 mentions)
N 2 p bromocinnamylamino ethyl 5 isoquinolinesulfonamide h89, by Bio-Techne (2 mentions)
3 3 3 dipropylthiadicarbocyanine iodide disc3 5, by Thermo Fisher Scientific (2 mentions)
4 aminopyridine 4 ap, by Merck Group (2 mentions)
7 chloro 5 2 chlorophenyl 1 5 dihydro 4 1 benzothiazepin 2 3h one cgp37157, by Bio-Techne (2 mentions)
Dantrolene, by Bio-Techne (2 mentions)
Bisindolylmaleimide 1 gf109203x, by Bio-Techne (2 mentions)
Horseradish peroxidase conjugated anti rabbit igg antibody, by Cell Signaling Technology (1 mentions)
Camkii, by Cell Signaling Technology (1 mentions)
Synapsin 1, by Cell Signaling Technology (1 mentions)
P camkii, by Cell Signaling Technology (1 mentions)
Adult male sprague dawley rats, by BioLASCO (1 mentions)
Fura 2 am, by Thermo Fisher Scientific (1 mentions)
Bafilomycin a1, by Bio-Techne (1 mentions)
3 protocols using ω agatoxin iva ω aga iva
1
Neurochemical Modulators in Synaptic Signaling
2
Neurochemical Regulation in Rat Brains
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HFP034 was synthesized by one of the authors (Pei-Wen Hsieh) [16] . dl-threo-β-benzyloxyaspartate (dl-TBOA), ba lomycin A1, dantrolene, 7-chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepin-2(3H)-one (CGP37157), and bisindolylmaleimide I (GF109203X) were purchased from Tocris (Bristol, UK). 3,3,3-Dipropylthiadicarbocyanine iodide [DiSC 3 (5) (link)], and fura-2-acetoxymethyl ester (Fura-2-AM) were purchased from Thermo (Waltham, USA). ω-conotoxin GVIA (ω-CgTX GVIA) and ω-agatoxin IVA (ω-Aga IVA) were purchased from Alomone lab (Jerusalem, Israel). 4-aminopyridine (4-AP), dimethylsulfoxide (DMSO), kainic acid (KA) and all other reagents were purchased from Sigma-Aldrich (St. Louis, MO, USA).
Adult male Sprague-Dawley rats (n = 42, 150-200 g) were purchased from BioLASCO (Taipei, Taiwan).
Adult male Sprague-Dawley rats (n = 42, 150-200 g) were purchased from BioLASCO (Taipei, Taiwan).
3
Pharmacological Tools for Neuronal Signaling
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Rosmarinic acid (purity > 98%, ChemFace, Wuhan, China), bafilomycin A1 (Tocris Bioscience, Bristol, United Kingdom), dantrolene (Tocris Bioscience), 7-chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepin-2(3H)-one (CGP37157, Tocris Bioscience), N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide (H89, Tocris Bioscience), bisindolylmaleimide I (GF109203X, Tocris Bioscience), 1-[N,O-Bis(5-isoquinolinesulfonyl)-N-methyl-l -tyrosyl]-4-phenylpiperazine (KN62, Tocris Bioscience), 3,3,3-dipropylthiadicarbocyanine iodide [DiSC3(5)] (Thermo, Waltham, MA, USA), and fura-2-acetoxymethyl ester (Fura-2-AM, Thermo) were made up in 10 mM stock solution in DMSO. DL-threo-β-benzyloxyaspartate (DL-TBOA, Tocris Bioscienc), ω-conotoxin GVIA (ω-CgTX GVIA, Alomone Lab, Jerusalem, Israel), and ω-agatoxin IVA (ω-Aga IVA, Alomone Lab) were made up in 5 mM stock solution in water. 4-aminopyridine (4-AP, Sigma-Aldrich, St. Louis, MO, USA) were made up in 300 mM stock solution in water.
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