Whole-body [18F]PSMA-1007-PET/CT was performed from the vertex to the upper thigh on a GE Discovery MI-4 PET/CT camera (GE Healthcare, Chicago, United States of America) with time-of-flight technology or a Siemens Biograph TruePoint PET/CT camera (Siemens, Erlangen, Germany). Imaging was started 81 ± 16 min (mean ± SD) after intravenous injection of 3 MBq/kg body weight [18F]PSMA-1007. Briefly, [18F]PSMA-1007 was produced on-site using a Trasis All-in-One synthesis module, reagent kit and precursor for PSMA-1007 from ABX and fluorine-18 from an in-house cyclotron [27 (link)]. PET scan was performed for 100 s per bed position on the MI-4 PET/CT camera and 180 s per bed position on the TruePoint PET/CT camera. On the MI-4 PET/CT and TruePoint PET/CT camera [18F]PSMA-1007 images were reconstructed using vendor-specific software with OSEM (ordered-subset expected maximization with 3 iterations and 21 subsets) iterative reconstruction and resolution recovery (Q.Clear, a Bayesian penalized likelihood (PL) reconstruction algorithm with a beta-factor to control smoothness (respectively 600 or 1250)). PET data were corrected for dead time, random coincidence events, scatter, decay and CT-based attenuation correction.
Biograph truepoint pet ct camera
Manufactured by Siemens
Sourced in Germany
The Biograph Truepoint PET/CT camera is a medical imaging device that combines positron emission tomography (PET) and computed tomography (CT) technologies. It is designed to capture high-quality, three-dimensional images of the human body for diagnostic and treatment planning purposes.
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3 protocols using biograph truepoint pet ct camera
1
Whole-body [18F]PSMA-1007 PET/CT Imaging
2
PET/CT Imaging of Subjects in Supine Position
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All subjects were studied in supine position using the same PET/CT camera, a 64-slice Siemens Biograph Truepoint PET/CT camera (Siemens AG, Erlangen, Germany). Patients fasted for at least 6 h before the study but were encouraged to drink water. Nine subjects had an Artflon catheter (Artflon, Ohmeda, Swindon, UK) placed percutaneously in a radial artery for blood sampling during the dynamic PET protocol.
3
PET/CT Imaging Protocol for Oncology
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Early imaging was done as per our routine departmental 18 F-FDG PET/CT imaging protocol for oncologic and inflammation/infection imaging. Briefly, all patients observed a minimum of 6 hours of fasting. Fasting blood sugar was obtained in all patients using a portable glucometer. The activity of 18 F-FDG administered was calculated using the formula: [(body weight in kg 710) ? 1] 9 37 MBq corresponding to 3-4 MBq recommended in the EANM position paper. 13 After an uptake period of 60 minutes (median = 64, range = 60 to 69), a vertex to mid-thigh non-contrasted CT followed by PET imaging was performed using a hybrid Biograph Truepoint PET/CT camera (Siemens Medical Solution, IL, USA). CT parameters were as follows: tube voltage = 120 KeV, tube current = 40 mAs, sectional width = 5 mm and pitch = 0.8, matrix = 512 9 512. CT data were used for attenuation correction and anatomic co-localization. PET imaging was done in 3D mode at 3 minutes per bed position. PET images were reconstructed using ordered subset expectation maximization (OSEM) iterative reconstruction algorithm (8 iterations) with a Gaussian filter applied at 5.0 mm full width at half maximum.
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