Innospire go

Manufactured by Philips

Sourced in United Kingdom

The InnoSpire Go is a portable nebulizer device designed for the delivery of aerosolized medications. It utilizes mesh technology to generate a fine, consistent mist for efficient medication administration. The device is compact, lightweight, and powered by a rechargeable battery, allowing for convenient and on-the-go use.

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Lab products found in correlation

Np0007, by Thermo Fisher Scientific (1 mentions)

4 protocols using innospire go

Nebulized SARS-CoV-2 Nanobody Evaluation

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Nanobody was nebulized with a portable mesh nebulizer (Philips, InnoSpire Go) producing 2-5 μm particles at a final concentration of 0.4 mg ml⁻¹. The resulting aerosol was collected by condensation into a 50-ml tube cooled on ice. Pre- and post-nebulization samples were analysed by NuPAGE gel and visualized by InstantBlue staining. SARS-CoV-2 surrogate virus neutralization test was also performed to compare the neutralization potency of pre- and post-nebulization samples. For thermostability tests, nanobodies supplemented with loading buffer (Thermo Fisher Scientifc, NP0007) and β-mercaptoethanol were heated at 98 °C for 10 min and then analysed on a NuPAGE gel and visualized by InstantBlue staining.

Xu J., Xu K., Jung S., Conte A., Lieberman J., Muecksch F., Lorenzi J.C., Park S., Schmidt F., Wang Z., Huang Y., Luo Y., Nair M.S., Wang P., Schulz J.E., Tessarollo L., Bylund T., Chuang G.Y., Olia A.S., Stephens T., Teng I.T., Tsybovsky Y., Zhou T., Munster V., Ho D.D., Hatziioannou T., Bieniasz P.D., Nussenzweig M.C., Kwong P.D, & Casellas R. (2021). Nanobodies from camelid mice and llamas neutralize SARS-CoV-2 variants. Nature, 595(7866), 278-282.

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Evaluating Nebulizers for Cystic Fibrosis

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Experiments were conducted using a selection of appropriate and commonly used nebulisers in the treatment of cystic fibrosis, and the escalating treatment of lung infection. In the homecare setting, both a compressed air-driven jet nebuliser (Up-draft II jet nebuliser, Hudson, Teleflex Medical, Wake County, NC, USA) as well as a portable vibrating mesh nebuliser (InnoSpire Go, Philips, Farnborough, UK) were evaluated. In the hospital setting, a second VMN was used (Aerogen Solo, Aerogen Ltd., Galway, Ireland).

Fernández Fernández E., Joyce M., O’Sullivan A, & MacLoughlin R. (2021). Evaluation of Aerosol Therapy during the Escalation of Care in a Model of Adult Cystic Fibrosis. Antibiotics, 10(5), 472.

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Mesh Nebulizer Aerosolization of Viruses

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A commercial mesh nebulizer (Philips Innospire Go) was used to accommodate small volumes of virus-containing liquids. This device was expected to produce aerosols with an average mean aerodynamic diameter of 3.99 ± 0.26 μm.⁵⁰ Only HEPA filters (liquid-coated or dry, n = 5) were used for these experiments due to their better performance in testing with bacteria-containing aerosols. A volume of 0.5 mL JCPyV or SARS-CoV-2 viral stock described in Section 2.3 was placed into the nebulizer and run until all of the stock was depleted or after 1 min, whichever came first.

Waxman R., Tennant A, & Helliwell P. (1998). Community survey of factors associated with consultation for low back pain. BMJ : British Medical Journal, 317(7172), 1564-1567.

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Replicating Aerosol Therapy for Adult CF Patients

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To replicate aerosol therapy in a spontaneously breathing adult CF patient undergoing standard care in the homecare setting, both the JN plus open facemask (Up-draft II jet nebuliser, Hudson, Teleflex Medical, Wake County, NC, USA) and portable VMN in combination with a mouthpiece (InnoSpire Go, Philips, Farnborough, UK) were used. The JN was operated at 7 L per minute compressed air flow rate, in line with the accompanying instruction manual. To replicate aerosol therapy in a spontaneously breathing adult CF patient post-exacerbation in the hospital setting a VMN in combination with an aerosol chamber and filtered mouthpiece (Aerogen Ultra, Aerogen Limited, Galway, Ireland) (Respirgard 303 filter, Baxter, Dublin, Ireland) with no supplemental oxygen was used to deliver drug to the simulated adult CF patient. See Figure 4A,B.

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