Atipamezole hydrochloride

Manufactured by Cayman Chemical

Atipamezole hydrochloride is a synthetic compound used in laboratory research. It functions as an antagonist of alpha-2 adrenergic receptors.

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Lab products found in correlation

U46619, by Cayman Chemical (1 mentions) N methylsulfonyl 2 2 propynyloxy benzenehexanamide msppoh, by Cayman Chemical (1 mentions) Alexa 488 hydrazide, by Thermo Fisher Scientific (1 mentions) Fitc dextran, by Merck Group (1 mentions) Rhodamine b isothiocyanate dextran, by Merck Group (1 mentions) Enrofloxacin, by Bayer (1 mentions) Meloxicam, by Boehringer Ingelheim (1 mentions)

2 protocols using atipamezole hydrochloride

Fluorescent Tracing and Calcium Imaging Protocol

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FITC-dextran (2000KDa), rhodamine B isothiocyanate-dextran (Rhodamine-B-dextran, 70KDa), dexamethasone 21-phopshate disodium, Chremophore® EL, DMSO were obtained from Sigma Aldrich. D-(-)-2-Amino-5-phosphonopentanoic acid (AP5) and Compound 21 dihydrochloride was purchased from Hello Bio Inc. (Princeton, NJ). U46619, N-(methylsulfonyl)-2-(2-propynyloxy)-benzenehexanamide (MSPPOH), medotomidine hydrochloride, and atipamezole hydrochloride were ordered from Cayman Chemicals. BAPTA-tetrapotassium and Alexa 488 hydrazide were obtained from Invitrogen, isoflurane from Fresenius Kabi Canada Ltd., Pluronic F127 and Rhod-2/AM from Biotium, buprenorphine from Champion Alstoe Animal Health, and enrofloxacin from Bayer, meloxicam from Boehringer Ingelheim, ketamine from Vétoquinol N.-A. Inc. AAV2/5.GfaABC₁D.GCamP6f and AAV9.hSyn.GCaMP6f were ordered from Penn Vector Core, PA, USA, pZac2.1-GfaABC₁D-mCherry-hPMCA2w/b plasmid was ordered from Addgene.

Institoris A., Vandal M., Peringod G., Catalano C., Tran C.H., Yu X., Visser F., Breiteneder C., Molina L., Khakh B.S., Nguyen M.D., Thompson R.J, & Gordon G.R. (2022). Astrocytes amplify neurovascular coupling to sustained activation of neocortex in awake mice. Nature Communications, 13, 7872.

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Noradrenaline Pharmacological Manipulation

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Noradrenaline bitartrate was dissolved in distilled water at a stock concentration of 100 mM and diluted in ACSF to 10 μM. Prazosin hydrochloride (Cayman Chemical, Ann Arbor, MI #15023) was dissolved in pure dimethyl sulfoxide at a 10 mM stock concentration and diluted to a final volume of 10 μM in ACSF. Atipamezole hydrochloride (Cayman Chemical, #9001181) was dissolved in distilled water at a stock concentration of 50 mM, sonicated for 2 minutes, and diluted to a final concentration of 10 μM in ACSF. Recordings were performed in the continuous presence of picrotoxin (50 μM). All solutions equilibrated at 34 ± 0.5 °C prior to slice application.

Munier J.J., Marty V.N, & Spigelman I. (2022). Sex differences in α-adrenergic receptor function contribute to impaired hypothalamic metaplasticity following chronic intermittent ethanol exposure. Alcoholism, clinical and experimental research, 46(8), 1384-1396.

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