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Rosuvastatin

Manufactured by Targetmol
Sourced in China

Rosuvastatin is a laboratory standard compound used for research and development purposes. It is a synthetic statin drug that functions as a selective and competitive inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, the rate-limiting enzyme in the biosynthesis of cholesterol.

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2 protocols using rosuvastatin

1

Evaluating Cardiovascular Pharmacotherapies

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TNF-α (#300-01A, PEPROTECH, Rocky Hill, USA); IL-1β (#200-01B; PEPROTECH, Rocky Hill, USA); oxLDL (#H7980, Solarbio, Beijing, China); DMSO (#A100231, Sangon Biotech, Shanghai, China); Atorvastatin (#222412-82-0, Cayman Biochem, Ann Arbor, Michigan, USA); Simvastatin (#79902-63-9, TargetMol, Shanghai, China); Rosuvastatin (#287714-41-4, TargetMol, Shanghai, China); Fenofibrate (#49562-28-9,TargetMol, Shanghai, China); Empagliflozin (#864070-44-0,TargetMol, Shanghai, China); Troglitazone (#97322-87-7, MCE, Shanghai, China); Metformin (#1115-70-4,TargetMol, Shanghai, China); Cilostazol (#73963-72-1,TargetMol, Shanghai, China); Fluvoxamine (#61718-82-9,TargetMol, Shanghai, China); Riociguat (#625115-55-1,TargetMol, Shanghai, China); Sildenafil citrate (#171599-83-0,TargetMol, Shanghai, China).
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2

Investigating Mevalonate Pathway Modulators

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Rosuvastatin (T1676), Pravastatin (T22405), Simvastatin (T0687), Fluvastatin (T1487), Pitavastatin (T2534), MG132 (T2154) and chloroquine (T8689) were purchased from TargetMol (Shanghai, China). Human IFNγ was purchased from PeproTech China (#300-02-1000, China) and mouse IFNγ was obtained from SinoBiological (50709-MNAH, Beijing, China). Mevalonic acid lithium salt (#90469) and cycloheximide (#239763-M) were from Sigma–Aldrich (Saint Louis, MO, USA). Actinomycin D was obtained from Selleck (S8964, Houston, TX, USA). Mevalonic acid lithium salt administrated in vivo was purchased from MedChemExpress (HY-113071A, NJ, USA), and anti-mouse PD-L1 antibody in vivo was purchased form BioXcell (BE0101, West Lebanon, NY, USA). d,l-Mevalonolactone-4,4,5,5-d4 (>99%) for LC–MS/MS detection was purchased from CDN Isotopes (Pointe-Claire, Quebec, Canada).
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