Smart apex 2 system

Unless otherwise specified, all the reagents were acquired from commercial sources and used directly. Acetonitrile, dichloromethane, dimethylformamide (DMF), and pyridine were all distilled from calcium hydride. NMR spectra (400 MHz/100 MHz) were recorded on an Advance DPX spectrometer (Bruker, Billerica, MA, USA) at room temperature with DMSO-d₆ or CDCl₃ as solvent. ¹H NMR data are reported as the following format: chemical shift, multiplicity (s = singlet, d = doublet, t = triplet, br = broad, m = multiplet), coupling constant and integration. Specific rotations were acquired on an Autopol IV polarimeter (Rudolph, Hackettstown, NJ, USA). High resolution mass spectrometry (HRMS) data were measured with an AB Sciex TOF 4600 instrument (AB Sciex, Singapore). Melting points were measured on an X-4 digital melting point apparatus (Beijing Taike Corparation, Beijing, China). X-ray diffraction analysis was performed on a Bruker Smart Apex II system (Bruker, Billerica, MA, USA).

Unless otherwise specified, all the reagents were acquired from commercial sources and used directly. NMR spectra (400 MHz/100 MHz) were recorded on an Advance DPX spectrometer (Bruker, Billerica, MA, USA) at room temperature with DMSO-d₆ as solvent. Tetramethylsilane (TMS) was used as an internal reference. Specific rotations were acquired on an Autopol IV polarimeter (Rudolph, Hackettstown, NJ, USA). High resolution mass spectrometry (HRMS) data were measured with an AB Sciex TOF 4600 instrument (Billerica, MA, USA). Melting points were measured on an X-4 digital melting point apparatus (Beijing Taike Corparation, Beijing, China). X-ray diffraction analysis was performed on a Bruker Smart Apex II system (Bruker, Billerica, MA, USA).