Magnetom trio 3.0t mri system

All MRI data analyses were performed at the MR Research Center of West China Hospital using the Magnetom Trio 3.0T MRI system (Siemens Healthineers) equipped with a standard eight-channel quadrature head coil. The imaging area covered the entire brain. All participants were informed of the contraindications of the MRI examination and other associated matters of importance. The MRI examination followed the standardized scanning procedures (27 (link)).
MRI scout images and three-dimensional structural T1-weighted images were initially obtained, followed by resting-state fMRI scanning. Structural T1-weighted images were obtained using a magnetization-prepared rapid gradient-echo sequence with the following parameters: Echo time (TE), 2.62 msec; repetition time (TR), 2,250 msec; field of view (FOV), 25.6×25.6 cm; flip angle (FA), 9°; matrix, 256×256. Resting-state functional images were obtained using an echo-planar imaging sequence with the following parameters: TE, 35 msec; TR, 2,000 msec; FOV, 20.8×20.8 cm; FA, 68°; matrix, 64×64.

MRI scanning was performed on a Siemens Magnetom Trio 3.0T MRI System (Siemens AG, Erlangen, Germany) using a standard birdcage head transmit and receive coil at baseline and after the 3-month intervention. Functional images were acquired using a single-shot, gradient-recalled echo planar imaging sequence [repetition time (TR)=2,000 msec; echo time (TE)=30 msec; flip angle (FA)=90°]. A total of 33 transverse slices [field of view (FOV) =256×256 mm²; in-plane matrix=64×64; slice thickness=4 mm; inter-slice gap=1 mm; voxel size=4×4×4 mm³] aligned along the anterior-posterior commissure line were acquired. For each subject, a total of 240 volumes were acquired, resulting in a total scan time of 480 sec. The subjects were instructed to simply rest with their eyes closed, to not think of anything in particular and to not fall asleep. The high-resolution 3D T1-weighted anatomical images were acquired in a sagittal orientation using a magnetization-prepared rapid gradient-echo sequence (TR=1,900 msec; TE=2.52 msec; FA=9°; FOV=256×256 mm²; matrix size=256×256; slice thickness=1 mm; inter-slice gap=0.5 mm; voxel size=1×1×1 mm³; 176 slices). Then, axial fluid-attenuated inversion recovery images (time of inversion=2,500 msec; TR=9,000 msec; TE=100 msec; slice thickness=5 mm) were obtained for diagnosis.