Ingenia 1.5 t system

Breast MRI was performed on a Philips Ingenia 1.5-T system using a dedicated 16-channel bilateral breast coil with parallel imaging capabilities (Philips Healthcare, Best, the Netherlands).
In addition to breast MRI for staging, the participants underwent two dynamic sequences applied in an interleaved pattern prior and during the injection of the contrast agent. The high temporal resolution images were acquired using a 3D T1_T2*-weighted multi echo-planar imaging sequence and intercalated with a dynamic high spatial resolution 3D T1-weighted turbo field echo sequence (3D T1W THRIVE). Details of the breast MRI sequences have been published previously and are found in Supplementary Table 2 [14 (link)]. The institutions breast imaging radiologists interpreted these examinations, according to the American College of Radiology Breast Imaging-Reporting and Data System (BI-RADS®) lexicon (ACR BI-RADS® Atlas 2013, https://www.acr.org/Clinical-Resources/Reporting-and-Data-Systems/Bi-Rads).

MR images of the phantom pair were acquired on a Philips Ingenia 1.5T system (Philips Healthcare, Best, the Netherlands). The acquisition was processed by using a segmented K-space gradient-echo cardiac sequence [21 (link), 22 (link)], with the left and right ventricular cavities filled with water. The MR images obtained had a 256 × 256-pixel matrix with 1.25 mm per pixel resolution and an 8-mm slice thickness. LVEF was manually calculated by transferring the images to the contouring module of Eclipse, delineating the left ventricle volumes, and then employing formula (1). LVEF was also automatically computed by a senior radiologist, using the Circle cvi42 software (Circle Cardiovascular Imaging Inc., Calgary, Canada).

CMR images analysis were performed concomitantly by two experienced radiologists who were blind to echocardiographic findings. Baseline magnetic resonance images were acquired using a Philips Ingenia 1.5 T system with Intellispace 6 console. For DE-CMR analysis, a 17-segment LV model was used. The protocol included short-axis and 4-chamber cine acquisitions, black blood sequences weighted in T2 and/or short tau inversion recovery in short-axis, first-pass dynamic perfusion sequence or early gadolinium enhancement (within the first 1–3 minutes after contrast infusion) to look for a microvascular obstruction indicating a no reflow, and late gadolinium enhancement (15 min after contrast infusion) using phase-sensitive inversion recovery sequences technique for the determination of transmurality.
The cut off value of 50% of DE was considered to define segmental myocardial viability.^{[7 (link)]} A myocardial territory was qualified as viable when more than half of its segments had a DE ≤50% and nonviable when half or more of its segments had a DE >50%.