Clbq14

Manufactured by Tokyo Chemical Industry

Sourced in Japan

CLBQ14 is a laboratory equipment product offered by Tokyo Chemical Industry. It is a multi-purpose device designed for use in various scientific applications. The core function of CLBQ14 is to perform controlled and precise laboratory tasks. Further details about the intended use or specific applications of this product are not available.

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Lab products found in correlation

2 protocols using clbq14

Biopharmaceutical Characterization Protocol

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CLBQ14 (purity ≥ 98%) was purchased from TCI Chemicals (Tokyo, Japan). LC-MS grade water and acetonitrile, clioquinol, formic acid, trifluoroacetic acid (TFA), ethanol, Tween 20, Tween 80, soybean oil, paraffin oil, olive oil, dimethyl sulfoxide (DMSO), N’N dimethyl acetamide (DMA), polyethylene glycol 400 (PEG 400), glycerol, 1-octanol, 0.85% sodium chloride solution, phosphate buffered saline tablets, and CD-1 mouse, Sprague Dawley (SD) rat, cynomolgus monkey and human microsomes were purchased from Sigma Aldrich (St. Louis, MO). Transcutol High Purity (HP)^®, Labrasol^® and Capyrol 90^® were gifts from Gattefosse (Lyon, France). Recombinant human cytochrome P450 enzymes (rhCYP) were purchased from BD Biosciences (San Jose, CA). Heparin (1000 units/mL) and pharmaceutical grade normal saline were purchased from Hospira (Lake Forest, IL). Human plasma was purchased from Gulf Coast Blood Center (Houston, TX) and fresh rat plasma was collected from male SD rats (Envigo RMS Inc., Indianapolis, IN) and stored at −80°C until use. CD-1 mouse and cynomolgus monkey plasma were purchased from BioIVT (Westbury, NY). All chemicals and reagents were used as received.

Ekpenyong O., Gao X., Ma J., Cooper C., Nguyen L., Olaleye O.A., Liang D, & Xie H. (2020). Pre-Clinical Pharmacokinetics, Tissue Distribution and Physicochemical Studies of CLBQ14, a Novel Methionine Aminopeptidase Inhibitor for the Treatment of Infectious Diseases. Drug Design, Development and Therapy, 14, 1263-1277.

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Quantitative Analysis of CLBQ14

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CLBQ14 (purity ≥ 98%) was purchased from TCI Chemicals (Tokyo, Japan). Clioquinol, LC-MS grade acetonitrile, water, and formic acid were purchased from Sigma Aldrich (St. Louis, MO). Heparin sodium injection (1000 units/mL) was purchased from Hospira (Lake Forest, IL). Adult male SD rats were purchased from Envigo RMS, Inc. Freshly obtained rat plasma and urine were collected from male SD rats from Envigo and stored at −80 °C until use. All chemicals and reagents were used as received.

Ekpenyong O., Cooper C., Ma J., Liang D., Olaleye O, & Xie H. (2018). A Simple, Sensitive and Reliable LC-MS/MS Method for the Determination of 7-bromo-5-chloroquinolin-8-ol (CLBQ14), A Potent and Selective Inhibitor of Methionine Aminopeptidases: Application to Pharmacokinetic Studies.. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1097-1098, 35-43.

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