Inveon research workplace software

Manufactured by Siemens

Sourced in United States, Germany, Switzerland

The Inveon Research Workplace software is a comprehensive platform designed for the management and analysis of data acquired from Siemens' Inveon preclinical imaging systems. The software provides a unified workflow for seamless data acquisition, processing, and visualization. It offers tools for image reconstruction, quantification, and reporting to support research activities.

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129 protocols using inveon research workplace software

18F-FDG PET Imaging of LPS-Induced Inflammation

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Animals were divided into six treatment groups; (18F)-FDG alone; LPS and (18F)-FDG, simultaneous, LPS and 60 min later (18F)-FDG, LPS and 120 min later (18F)-FDG, LPS and 4 h later (18F)-FDG, LPS and 6 h later (18F)-FDG. The (18F)-FDG (obtained as an aliquot from daily clinical productions at Karolinska University Hospital, Solna, Sweden; 7–8 MBq per mouse, maximum volume of 200 μl) was administered to awake, warmed (37°C) mice by a bolus injection via the tail vein. 40 min after the tracer injection, animals were anesthetized with isoflurane (5% initially, 1.5% maintenance) and placed on a heated pad (37°C). Emission data were collected for 20 min in list mode and processed using the MicroPET Focus 120 scanner (CTI Concorde Microsystems). PET data were acquired in 3D mode and images were reconstructed by standard 2-D filtered back projection using a ramp filter. The matrix size of the reconstructed images was 128 × 128 × 95 with a spatial resolution of 1.3 mm.
The 18F-FDG uptake in heart and brown tissues was quantified as standard uptake values, SUVmax (the highest SUV in a region of interest, ROI) and SUVmean (the average intensity of uptake in a ROI), using Inveon Research Workplace software (Siemens Medical Solutions) and normalized to the administered activity (MBq/body weight, gram).

Fitzpatrick S.F., Gojkovic M., Macias D., Tegnebratt T., Lu L., Samén E., Rundqvist H, & Johnson R.S. (2018). Glycolytic Response to Inflammation Over Time: Role of Myeloid HIF-1alpha. Frontiers in Physiology, 9, 1624.

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Maxillary Molar Morphometry via Micro-CT

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The mice maxillae were scanned using the micro-computed tomography (Micro-CT) system. The distance between the cementoenamel junction (CEJ) and the alveolar bone crest (ABC), the bone volume/tissue volume (BV/TV) ratio, and bone mineral density (BMD) in the region of interest of the maxillary second molar were analyzed with Inveon Research Workplace software (Siemens, Berlin, Germany).

Zhang J., Wang X., Lu R., Zou P., Zhan Y, & Meng H. (2022). Preliminary study on the involvement of platelets in mouse experimental periodontitis. Journal of Dental Sciences, 17(4), 1494-1500.

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Quantifying Bone Volume Using CT-Scan Imaging

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The bone specimens were examined by CT-scan, using Inveon TM unit (Siemens Healthcare USA, Inc., PA, USA). They were scanned at 0.06-mm thickness sections at the longitudinal and transverse views. The images were reconstructed by Inveon Research Workplace software (Siemens Healthcare USA, Inc., PA, USA) to create 3-D images of the newly formed bone. Bone volume of the bone defects reported as percentage was calculated from the acquired images by the software ImageJ (version 1.51 Mac, National Institutes of Health, USA; http://imagej.nih.gov/ij), based on the following formulation and analyzed statistically.

Oryan A., Alidadi S., Bigham-Sadegh A, & Moshiri A. (2018). Healing potentials of polymethylmethacrylate bone cement combined with platelet gel in the critical-sized radial bone defect of rats. PLoS ONE, 13(4), e0194751.

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Glucose Imaging in Fasted Mice

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Mice were withheld food 12–24 h prior to imaging. On the day of imaging, mice were anesthetized with 1.5–2% isoflurane in oxygen inside of a Plexiglas chamber and subsequently injected with fludeoxyglucose (FDG, 100 µl/20g mouse). Mice were imaged using microCT to obtain anatomical scans, and then undergo a 10 min transmission scan followed by a 10 min emission scan. All imaging was performed via a Siemens Inveon-MM microCT/PET imager. Co-registration and analysis was performed using Siemens Inveon Research Workplace software.

Perry J.S., Russler-Germain E.V., Zhou Y.W., Purtha W., Cooper M.L., Choi J., Schroeder M.A., Salazar V., Egawa T., Lee B.C., Abumrad N.A., Kim B.S., Anderson M.S., DiPersio J.F, & Hsieh C.S. (2018). Scavenger receptor CD36 mediates cell-surface antigen transfer to promote thymic regulatory T cell receptor repertoire development and allo-tolerance. Immunity, 48(5), 923-936.e4.

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In Vivo SPECT/CT Imaging of Antibodies

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For each construct, mice (n = 5/group) received 0.4 pmol ¹¹¹In-labelled tracer (8 MBq, 200 µL). For Fab, scans were acquired at 4 h and 24 h post-injection (p.i.), for Fab-PEG at 4 h, 24 h and 48 h, and the full length antibodies were imaged at 24 and 72 h p.i.. Images were acquired for 45 min under general anesthesia (isoflurane in 100% oxygen, 5% for induction, 2% maintenance) with the U-SPECT-II/CT (MILabs, Utrecht, The Netherlands) using a 1.0 mm diameter pinhole mouse high sensitivity collimator, followed by CT scan (615 µA, 65 kV) for anatomical reference. Scans were reconstructed with MILabs reconstruction software using a 16-subset expectation maximization algorithm, with a isotropic voxel size of 0.2 mm and 1 iteration. SPECT/CT scans were analyzed and maximum intensity projections (MIP) were created using Inveon Research Workplace software (Siemens).

Hagemans I.M., Wierstra P.J., Steuten K., Molkenboer-Kuenen J.D., van Dalen D., ter Beest M., van der Schoot J.M., Ilina O., Gotthardt M., Figdor C.G., Scheeren F.A., Heskamp S, & Verdoes M. (2022). Multiscale imaging of therapeutic anti-PD-L1 antibody localization using molecularly defined imaging agents. Journal of Nanobiotechnology, 20, 64.

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Longitudinal PET-CT Imaging in Cancer Xenografts

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PET-CT (Inveon Micro-PET/CT, Siemens) was performed after 2 weeks of inoculation for grouping and another 2 weeks for treatment. BALB/C-nu mice were anesthetized and injected with 2-deoxy-2-[fluorine-18] fluoro-D-glucose (¹⁸F-FDG) in 100 μl of saline via the tail vein. All mice were kept fasting, with access to water, for 24 h before ¹⁸F-FDG administration and imaging. The mice were maintained under anesthesia and were imaged after 60 min of the injection. Images were reconstructed using an ordered-subset expectation maximization, followed by a maximum a posteriori probability reconstruction algorithm with no attenuation correction and no correction for partial-volume effects. Quantification was performed by volume-of-interest (VOI) analysis using Inveon Research Workplace software (Siemens).

Chiang C.L., Ma Y., Hou Y.C., Pan J., Chen S.Y., Chien M.H., Zhang Z.X., Hsu W.H., Wang X., Zhang J., Li H., Sun L., Fallen S., Lee I., Chen X.Y., Chu Y.S., Zhang C., Cheng T.S., Jiang W., Kim B.Y., Reategui E., Lee R., Yuan Y., Liu H.C., Wang K., Hsiao M., Huang C.Y., Shan Y.S., Lee A.S, & James Lee L. (2023). Dual targeted extracellular vesicles regulate oncogenic genes in advanced pancreatic cancer. Nature Communications, 14, 6692.

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In Vivo PET Imaging of Tumor Uptake

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All animal experiments were performed by following the protocols described in references [22 ,23 (link)]. Mice were anaesthetised with isoflurane/oxygen and injected with approximately 1.1-MBq [¹⁸F]-D4-FCH via a tail vein cannula. Mice remained anaesthetised during a 1-h dynamic PET emission scan in a thermostatically controlled rig on a small animal Genysis4 PET scanner (SOFIE Bioscience, Culver City, CA, USA). The PET scans of mice over 1 h were acquired in the list-mode format for image reconstruction using the maximum-likelihood expectation maximisation method; the decay-corrected imaging data were exported and analysed by Inveon Research Workplace software (Siemens, Munchen, Germany) for visualisation of the tracer uptake. The tumour radioactivity was normalised to that of the whole body to obtain the normalised uptake value (NUV), as previously reported in reference [22 ]. The area under the NUV curve from 0 to 60 min (AUC) and the ratio of the NUV at 60 min relative to 3.5 min (fractional retention; FRT) were also calculated.

Li Y., Inglese M., Dubash S., Barnes C., Brickute D., Braga M.C., Wang N., Beckley A., Heinzmann K., Allott L., Lu H., Chen C., Fu R., Carroll L, & Aboagye E.O. (2021). Consideration of Metabolite Efflux in Radiolabelled Choline Kinetics. Pharmaceutics, 13(8), 1246.

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In Vivo Imaging of Kidney Injury

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Following ⁸⁹Zr labeling of SeCQDs, 80–120 µCi (2.96‐4.44 MBq) of ⁸⁹Zr‐DFO‐SeCQDs was administered intravenously to ICR mice that were either healthy or had AKI induced by either 50% glycerol or cisplatin (n = 3). Longitudinal positron emission tomography (PET) scans were obtained using an Inveon microPET/CT rodent model scanner (Siemens Healthineers, Germany). At the time point of interest, mice were anesthetized with isoflurane (2% in oxygen) and placed on the bed of the PET scanner. During the initial three time‐points (5 min, 1 h, 4 h) p.i., 40 million coincidence events were collected whereas 30 million were collected for the remaining. PET data was reconstructed by 3D ordered‐subset expectation maximization followed by maximum a posteriori reconstruction (OSEM3D/MAP) and decay corrected using the Inveon Research Workplace software (Siemens Healthineers, Germany). Region‐of‐interests were drawn at each time‐point to quantify the biodistribution in each tissue of interest (blood, liver, spleen, kidney, bone). After the PET scan at the terminal time‐point, the mice were euthanized, and the organs were collected to quantify biodistribution ex vivo using a gamma counter (Perkin Elmer, USA). SeCQDs uptake in tissue was determined as a percentage of the injected dose per gram of tissue (%ID/g).

Rosenkrans Z.T., Sun T., Jiang D., Chen W., Barnhart T.E., Zhang Z., Ferreira C.A., Wang X., Engle J.W., Huang P, & Cai W. (2020). Selenium‐Doped Carbon Quantum Dots Act as Broad‐Spectrum Antioxidants for Acute Kidney Injury Management. Advanced Science, 7(12), 2000420.

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In-Vivo Molecular Imaging of Abdominal Aortic Aneurysm

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Dynamic PET scan and corresponding computed tomography (CT) images were obtained using Inveon MM PET/CT (Siemens, Malvern, PA) at 45–60 min after a tail vein injection of ⁶⁴Cu-DOTA-ECL1i (11.1 MBq per rat) to minimize the effect of blood retention on AAA uptake. To localize tracer uptake, a CT contrast agent (1.0 mL, eXIA 160XL, Binitio, Canada) was administrated via tail vein after PET imaging. Contrast-enhanced CT (Bin of 2, 90 mm axial FOV, 60kV, 500μA, 500ms exposure time, 10 ms settle time, no magnification, pixel size: 80–100μm) was performed. The organ uptake was calculated as standardized uptake value (SUV) in three-dimensional regions of interest (ROIs) from PET images without correction for partial volume effect using Inveon Research Workplace software (Siemens).^{33 (link)} Competitive PET blocking studies were performed in the AAA rat model with co-injection of non-radiolabeled ECL1i and ⁶⁴Cu-DOTA-ECL1i (ECL1i:⁶⁴Cu-DOTA-ECL1i molar ratio = 500:1), followed by a 45–60 minute dynamic scan. Dynamic (0–90 min)¹⁸F-FDG (41.1 MBq per rat) PET was also performed in AAA rats at day 7 PEE.

English S.J., Sastriques S.E., Detering L., Sultan D., Luehmann H., Arif B., Heo G.S., Zhang X., Laforest R., Zheng J., Lin C.Y., Gropler R.J, & Liu Y. (2020). CCR2 positron emission tomography for the assessment of abdominal aortic aneurysm inflammation and rupture prediction. Circulation. Cardiovascular imaging, 13(3), e009889.

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Zebrafish Vertebrae Density Quantification

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To measure zebrafish vertebrae density, fish were fixed in a stretched position on a sample holder and scanned with a microcomputed tomography (μ-CT) system (Siemens, USA). Experiments were performed on an animal Inveon system in the Ochang Center at the Korea Basic Science Institute. The μ-CT scanner was set to 80 kVp for the X-ray tube, 500 μA for the X-ray source, and 800-ms exposure time. The detector and Xray source were rotated 360° in 360 steps. The number of calibration exposures was 30. The system magnification was set to 102.55 mm axial field view and 30.74 mm transaxial field view. Data were analyzed using Inveon Research Workplace software (Siemens).

Park C.M., Kim H.M., Kim D.H., Han H.J., Noh H., Jang J.H., Park S.H., Chae H.J., Chae S.W., Ryu E.K., Lee S., Liu K., Liu H., Ahn J.S., Kim Y.O., Kim B.Y, & Soung N.K. (2016). Ginsenoside Re Inhibits Osteoclast Differentiation in Mouse Bone Marrow-Derived Macrophages and Zebrafish Scale Model. Molecules and Cells, 39(12), 855-861.

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