Ta dsc q20

The amorphous nature of the ribbons was confirmed by x-ray diffraction using Cu-K radiation in the Rigaku SmartLab X-Ray Diffractometer. The differential scanning calorimeter (DSC) measurements were conducted by using a TA #DSC Q20 at a heating rate of 20 K min⁻¹. Atomic force microscope (AFM) characterization was performed to check the surface topography after nanoindentation tests using a non-contact Scan Asyst-Air (Bruker Dimension icon with Scan Asyst, USA) mode. The relaxation behaviors of these glass ribbons were characterized by dynamical mechanical spectroscopy (DMS) on a TA Q800 at a constant heating rate of 3 K min⁻¹ with the frequency of 4 Hz. Additionally, the energy dispersive X-ray (EDX) characterization was also performed on the as-spun and oxidized La₆₀Ni₁₅Al₂₅ ribbons (exposed in air for one month), as shown in Supplementary Fig. 18, which proves the negligible effect of oxidization at the as-spun state.

The crystallinity of free ATO, carrier, surfactant, and SD were further investigated using a TA DSC Q20 instrument (TA Instruments; Newcastle, DE, USA). Approximately 5 mg of sample was weighed, sealed, and placed in an aluminum pan. The samples were heated from 30 °C to 220 °C at a constant temperature change rate of 10 °C/min under nitrogen gas flow at 50 mL/min. A physical mixture (PM) was prepared by mixing the polymer, surfactant, and the drug at the same weight ratio as that of the optimized ATO-loaded SD (F2).

A differential scanning calorimeter (TA DSC Q20; TA Instruments; Newcastle, DE, USA) was employed for thermal analysis. Approximately 5 mg of samples were weighed, sealed, and placed in an aluminum pan. The samples were heated from 50 °C to 300 °C at a constant temperature change rate of 10 °C/min under a nitrogen gas flow of 50 mL/min. All the measurement data were analyzed using the TA 2000 analysis software.