Pyridazine

Manufactured by Merck Group

Sourced in Germany

Pyridazine is a heterocyclic aromatic organic compound with the chemical formula C4H4N2. It is a colorless liquid with a characteristic odor. Pyridazine is a fundamental chemical building block used in the synthesis of various pharmaceutical and agrochemical products.

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Lab products found in correlation

Acetonitrile, by Thermo Fisher Scientific (2 mentions) Sterile water for injection, by Baxter (1 mentions) Formic acid, by Merck Group (1 mentions) Dimethylformamide, by Merck Group (1 mentions) Hydrochloric acid (hcl), by Honeywell (1 mentions) Triazole, by Merck Group (1 mentions) Unilab glovebox, by MBraun (1 mentions) Phthalazine, by Merck Group (1 mentions) Methanol d4, by Merck Group (1 mentions)

3 protocols using pyridazine

Radiolabeling and Purification of [18F]AmBF3-TATE

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[¹⁹F]AmBF₃-TATE was ordered from AmbioPharm Inc. Saline of USP grade and sterile water for injection were purchased from Baxter. Dimethylformamide (DMF), pyridazine, potassium hydrogen difluoride, and formic acid were purchased from Sigma-Aldrich. Hydrochloric acid for trace analysis was purchased from Honeywell. Ethanol was purchased from Commercial Alcohols. Acetonitrile was purchased from ThermoFisher Scientific. Ascorbic acid injection was purchased from Sandoz.
No-carrier-added ¹⁸F-fluorine was produced by bombardment of [¹⁸O]H₂O (Huayi Isotopes Co.) with 18-MeV protons. Target irradiations were performed on a TR-19 cyclotron system (Advanced Cyclotron Systems Inc.) at the Department of Functional Imaging, BC Cancer Vancouver, Canada.

Lau J., Pan J., Rousseau E., Uribe C.F., Seelam S.R., Sutherland B.W., Perrin D.M., Lin K.S, & Bénard F. (2020). Pharmacokinetics, radiation dosimetry, acute toxicity and automated synthesis of [18F]AmBF3-TATE. EJNMMI Research, 10, 25.

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Radiolabeling Procedure for [99Tc]Tc-Complexes

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Caution! ⁹⁹Tc is a β-emitter (A = 635 Bq/μg [67 ], E_max = 290 keV); appropriate shielding and manipulation technics were employed during the synthesis and in all manipulations.
Pirimydine, 2,5-dimethilpyrazole, pyridazine, triazole were purchased from Sigma-Aldrich (Darmstadt, Germany). All reagents and solvents were qualified chemically pure and were not subjected to further purification.
The ammonium pertechnetate (ISOTOP RF) used in the work was recrystallized from bidistilled water (R ≥ 18 MΩ). The resulting white crystalline powder was especially pure and spectrally pure.

Novikov A.P, & Volkov M.A. (2022). New O- and N-N-Bridging Complexes of Tc(V), the Role of the Nitrogen Atom Position in Aromatic Rings: Reaction Mechanism, Spectroscopy, DTA, XRD and Hirshfeld Surface Analysis. International Journal of Molecular Sciences, 23(22), 14034.

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Schlenk Synthesis of Iridium Complex 1

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All the experimental procedures associated with this work were carried out under nitrogen using standard Schlenk techniques or in an MBraun Unilab glovebox. The solvents used in the synthetic chemistry were dried using an Innovative Technology anhydrous solvent system, or distilled from an appropriate drying agent under nitrogen. Methanol-d₄, pyridazine and phthalazine were obtained from Sigma-Aldrich and used as supplied. [Ir(IMes)(COD)Cl] (1) was prepared according to literature methods.45

Appleby K.M., Mewis R.E., Olaru A.M., Green G.G., Fairlamb I.J, & Duckett S.B. (2015). Investigating pyridazine and phthalazine exchange in a series of iridium complexes in order to define their role in the catalytic transfer of magnetisation from para-hydrogen †Electronic supplementary information (ESI) available: Synthesis, Characterisation, kinetic and hyperpolarisation data with the kinetic model is available here. See DOI: 10.1039/c5sc00756a. Chemical Science, 6(7), 3981-3993.

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