The details of the synthesis of cholinium-based GB-ILs have been described in a previous work [50 (link)]. Briefly, the [Ch][OH] solution was added slowly to an aqueous solution of slightly excess equimolar buffer under constant stirring, at room temperature, and overnight. The mixture was then subjected to evaporation at 60°C under vacuum. The resultant residue (viscous liquid) was dissolved in a mixture of acetonitrile and methanol (1:1) and stirred vigorously for 1 h to precipitate the excess buffer and filtered off. The GB-IL product was then evaporated at room temperature under vacuum for 3 days. The water content of the investigated GB-ILs was determined by Karl–Fischer titration (Metrohm Ltd., model 831) and was found to be less than 0.05 wt%. The synthesized compounds were characterized by 1H and 13C NMR spectroscopy (Bruker AMX 300) operating at 300.13 and 75.47 MHz, respectively, and their melting points were measured by differential scanning calorimetry (DSC) using a Perkin Elmer DSC-7 instrument (Norwalk, CT) with a heating rate of 5 °C/min under a N2 flow of 40 mL·min-1. The NMR data and melting points are reported in Table S1 in the Supporting Information.
Dsc 7 instrument
Manufactured by PerkinElmer
Sourced in United States
The DSC-7 instrument is a differential scanning calorimeter that measures the heat flow associated with phase transitions and chemical reactions in materials as a function of temperature and time. It provides quantitative and qualitative data on thermal events within a sample.
Automatically generated - may contain errors
Lab products found in correlation
8 protocols using dsc 7 instrument
1
Synthesis and Characterization of Cholinium-based GB-ILs
2
Thermal Analysis of Sample Melting
Check if the same lab product or an alternative is used in the 5 most similar protocols
+ Expand
Thermal transitions were measured by means of a Perkin Elmer DSC7 instrument (Waltham, MA, USA) equipped with a liquid sub ambient accessory and calibrated with high purity standards. Weighed samples of ca. 10 mg were encapsulated in aluminum pans and heated from −80 °C to about 40 °C above fusion temperature at a rate of 20 °C/min (first scan), held there for 3 min, rapidly quenched at 100 °C/min to −80 °C, and reheated to a temperature well above the melting point of the sample, at a heating rate of 20 °C/min (second scan). The melting temperature (Tm) was determined as the peak value of the endothermal phenomena in the DSC curve. If multiple endotherms were observed, the highest peak was taken as Tm. The heat of fusion (ΔHm) of the crystal phase was calculated from the total area of the DSC endotherm. At least three replicates were run for each sample.
3
Synthesis and Characterization of Glycerol-Based Ionic Liquids
4
Differential Scanning Calorimetry Analysis
Check if the same lab product or an alternative is used in the 5 most similar protocols
+ Expand
A DSC7 instrument (PerkinElmer, Norwalk, Connecticut) in conjunction
with the Pyris 8.0 Software was used to analyze the samples. The samples
were precisely weighed using a UM3 ultramicrobalance (Mettler, Greifensee,
Switzerland). Approximately 2–5 mg of the sample were used,
and the analysis employed a heating rate of 10 °C min–1, with a N2 purge gas flow of 20 mL min–1. Enthalpies were derived from hermetically sealed capsules with
a minimum of three measurements, and error estimation was performed
at a 95% confidence interval. The solvates were additionally measured
with pierced lids. The calorimeter underwent calibration using benzophenone
(48.0 °C) and caffeine (236.2 °C) for temperature calibration
and indium (28.45 J g–1) for enthalpy calibration.
with the Pyris 8.0 Software was used to analyze the samples. The samples
were precisely weighed using a UM3 ultramicrobalance (Mettler, Greifensee,
Switzerland). Approximately 2–5 mg of the sample were used,
and the analysis employed a heating rate of 10 °C min–1, with a N2 purge gas flow of 20 mL min–1. Enthalpies were derived from hermetically sealed capsules with
a minimum of three measurements, and error estimation was performed
at a 95% confidence interval. The solvates were additionally measured
with pierced lids. The calorimeter underwent calibration using benzophenone
(48.0 °C) and caffeine (236.2 °C) for temperature calibration
and indium (28.45 J g–1) for enthalpy calibration.
5
Skin Characterization with MTX-RM
Check if the same lab product or an alternative is used in the 5 most similar protocols
+ Expand
The skin treated with MTX-RM (W0 = 10) was washed with ethanol to remove any sticking
stuff on the surface. Prior to the differential scanning calorimeter
(DSC) measurement, 10 mg of the treated skin was freeze-dried for
DSC, and those results were recorded on a PerkinElmer DSC-7 instrument
(Norwalk, USA) at a heating rate 10 °C/min. Attenuated total
reflecting ATR-FT-IR (Shimadzu, Japan) was used to elucidate the interaction
of MTX with RM (W0 = 10) and skin components
using the Zinc selenide horizontal cell.
stuff on the surface. Prior to the differential scanning calorimeter
(DSC) measurement, 10 mg of the treated skin was freeze-dried for
DSC, and those results were recorded on a PerkinElmer DSC-7 instrument
(Norwalk, USA) at a heating rate 10 °C/min. Attenuated total
reflecting ATR-FT-IR (Shimadzu, Japan) was used to elucidate the interaction
of MTX with RM (W0 = 10) and skin components
using the Zinc selenide horizontal cell.
6
Thermal Analysis of Mefenamic Acid Patches
Check if the same lab product or an alternative is used in the 5 most similar protocols
+ Expand
The DSC7 instrument (Perkin Elmer, USA) was used to determine the thermal behavior of the mefenamic acid matrix patches. The each mefenamic acid matrix patch was weighed about 10 mg into the DSC pan and hermetically sealed. The heating scan was 25°C to 400°C under a liquid nitrogen atmosphere with a heating rate of 10°C/min.
7
Differential Scanning Calorimetry of Samples
Check if the same lab product or an alternative is used in the 5 most similar protocols
+ Expand
DSC experiments were performed using testing machine (DSC 7 instrument, Perkin Elmer Instruments, USA). The heating rate and heat flow were calibrated at 10°C·min−1 using indium and zinc standard. The heat flow rate was set at 10°C·min−1 and inert nitrogen atmosphere (3.5 Bar) was employed. Approximately 5 mg of every sample was weighed in vented aluminium pan with crimp-on lid. All samples were analyzed over the temperature range 50–250°C except the ones containing guar gum due to early decomposition onset.
8
Thermal Analysis of Ionic Liquid Drug
Check if the same lab product or an alternative is used in the 5 most similar protocols
+ Expand
Thermal behaviors of lidocaine/aspirin ionic liquid drug were determined by the DSC and TGA methods. The DSC method used the DSC-7 instrument (Perkin Elmer, USA) to determine. A sample of about 5 mg was weighed into the DSC pan and then hermetically sealed. The heating rate was 10° C/min from 25° C to 300° C in a liquid nitrogen atmosphere. The DSC thermogram was reported, and the endothermic transition was observed. The TGA method also used the Perkin Elmer TGA-7 instrument to determine. The sample was prepared and placed into the TGA pan. It was analyzed at a heating rate of 10° C/min from 50° C to 500° C under nitrogen flushing with 100 mL/min of gas flow. The TGA thermogram was reported, and the derivative thermogravimetry (DTG) was calculated.
Preparation of blank and lidocaine/aspirin ionic liquid-loaded patches Aqueous gelatin and PVA solutions were prepared by dissolving 10 wt% gelatin and 10 wt% PVA in deionized water for 6 h at 90°C, and the glycerin, used as a plasticizer, was added to the polymer mixture after cooling it to room temperature. In some cases, the prepared lidocaine/aspirin ionic liquid drug was mixed at 5 wt%. The prepared aqueous solution was cast in a Petri dish with surface areas of 70.88 cm 2 . The sample was then exposed to ten cycles of freezing for 8 h at -20 °C and thawing for 4 h at 25 °C.
Preparation of blank and lidocaine/aspirin ionic liquid-loaded patches Aqueous gelatin and PVA solutions were prepared by dissolving 10 wt% gelatin and 10 wt% PVA in deionized water for 6 h at 90°C, and the glycerin, used as a plasticizer, was added to the polymer mixture after cooling it to room temperature. In some cases, the prepared lidocaine/aspirin ionic liquid drug was mixed at 5 wt%. The prepared aqueous solution was cast in a Petri dish with surface areas of 70.88 cm 2 . The sample was then exposed to ten cycles of freezing for 8 h at -20 °C and thawing for 4 h at 25 °C.
About PubCompare
Our mission is to provide scientists with the largest repository of trustworthy protocols and intelligent analytical tools, thereby offering them extensive information to design robust protocols aimed at minimizing the risk of failures.
We believe that the most crucial aspect is to grant scientists access to a wide range of reliable sources and new useful tools that surpass human capabilities.
However, we trust in allowing scientists to determine how to construct their own protocols based on this information, as they are the experts in their field.
Ready to get started?
Sign up for free.
Registration takes 20 seconds.
Available from any computer
No download required
Revolutionizing how scientists
search and build protocols!