Signa excite hdxt 3.0t

Animals were maintained and handled in accordance with the recommendations of the U.S. National Institutes of Health and the guidelines of the Central Research Laboratory, Hamamatsu Photonics. The following experiments were approved by the Ethical Committee of the Central Research Laboratory, Hamamatsu Photonics.
Five male normal and 5 MPTP-treated cynomolgus monkeys (Macaca fascicularis; age range, 2.8-3.3 y; weight range, 2.0-3.5 kg) were subjected to PET scans (9, 10) . MPTP at doses ranging from 0.2 to 0.4 mg/kg of free base in phosphate-buffered saline was injected intravenously once per week over a 4-mo period until a stable parkinsonian syndrome was observed. The total doses of MPTP administered ranged from 1.5 to 3.0 mg/kg. To avoid the possibilities of spontaneous recovery and direct inhibition of 18 F-BCPP-EF binding to MC-I by MPTP, MPTP administration was halted for 2 mo, from the last MPTP treatment to the first PET measurements.
MR images of the monkeys were obtained with a 3.0-T MR system (Signa Excite HDxt 3.0T; GE Healthcare) under pentobarbital anesthesia.

Twelve young-adult male rhesus monkeys (Macaca mulatta: age range, 7.1-9.4 y old; weight range, 4.0-6.0 kg) were maintained and handled in accordance with the recommendations of the U.S. National Institutes of Health and the guidelines of the Central Research Laboratory, Hamamatsu Photonics K.K. The experiments were approved by the Ethical Committee of the Central Research Laboratory, Hamamatsu Photonics K.K. (approval HPK-2015-15) .
MR images of the monkeys were obtained with a 3.0-T scanner (Signa Excite HDxt 3.0T; GE Healthcare Japan) using a 3-dimensional spoiled gradient echo sequence under pentobarbital anesthesia.
Kryptofix222 and K 2 CO 3 Á1.5H 2 O were from Merck Milipore. Anhydrous CH 3 CN, dimethylformamide, dimethyl sulfoxide, silver trifluoromethanesulfonate, Tris(dibenzyldeneacetone)dipalladium(0), trio-tolylphosphine, and MPTP were from Sigma-Aldrich Japan. Precursors of 11 C-DASB, 18 F-MPPF, 6-11 C-methyl-m-tyrosin ( 11 C-6MemTyr), 11 Craclopride, 11 18 F-BCPP-EF, and their corresponding standard compounds were from NARD Institute Ltd.