In the morning following the sleep study, a blood profile was performed for every individual. Serum C-reactive protein (CRP) was measured using the Architect c16000 platform (Abbott Diagnostics, Abbott Park, IL, USA), with a reference interval of 0.0–0.5 mg·dL−1. Complete blood count (CBC) analyses were carried out using the Cell-Dyn Sapphire (Abbott Diagnostics, USA) in K2EDTA–whole blood.
Architect c16000 platform
Manufactured by Abbott
Sourced in United States
The Architect c16000 platform is a high-throughput diagnostic instrument designed for clinical laboratories. It provides automated processing and analysis of clinical samples, delivering rapid and reliable results. The core function of the Architect c16000 is to perform a variety of clinical chemistry and immunoassay tests efficiently and accurately, supporting healthcare professionals in their diagnostic decision-making.
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2 protocols using architect c16000 platform
1
Blood Profile Analysis Protocol
2
Maternal Inflammation Assessment Protocol
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The morning after the PSG, anthropometric variables, and blood samples were collected from all women in fasting conditions. Laboratory data included complete blood count (Cell-Dyn Sapphire Platform, Abbott Diagnostics), coagulation, kidney and liver function tests (Architect c16000 platform. Abbott Diagnostics, US). Insulin was determined by processing serum samples on the Cobas e-411 platform (Roche Diagnostics GmbH, Germany) with a reference range of 3–25 μUI/mL. The Homeostatic model assessment of insulin resistance index (HOMA-IR) was calculated by the usual formula (28 (link)).
The remaining blood sample was centrifuged at 2,500 rpm for 10 min to isolate the plasma. The different plasma aliquots were stored at −80° C for further determinations.
The inflammatory cytokines were analyzed on plasma samples by multiplex technique using the Human High Sensitivity Cytokine Base Kit A (Magnetic Luminex® Performance Assay, R&D Systems®, Inc.) following the indicated procedure. For each one of the cytokines, analyzed the detection limits and coefficients of variation were 0.29 pg/mL and 5.2% (TNF-α), 0.08 pg/mL and 5.3% (IL-1β), 0.14 pg/mL and 5.2% (IL-6), 0.04 pg/mL and 6.6% (IL-8), 0.21 pg/mL and 5.4% (IL-10).
Following the delivery day, anthropometric and neonatal variables were collected from all newborns. Laboratory researchers were blinded to maternal status.
The remaining blood sample was centrifuged at 2,500 rpm for 10 min to isolate the plasma. The different plasma aliquots were stored at −80
The inflammatory cytokines were analyzed on plasma samples by multiplex technique using the Human High Sensitivity Cytokine Base Kit A (Magnetic Luminex® Performance Assay, R&D Systems®, Inc.) following the indicated procedure. For each one of the cytokines, analyzed the detection limits and coefficients of variation were 0.29 pg/mL and 5.2% (TNF-α), 0.08 pg/mL and 5.3% (IL-1β), 0.14 pg/mL and 5.2% (IL-6), 0.04 pg/mL and 6.6% (IL-8), 0.21 pg/mL and 5.4% (IL-10).
Following the delivery day, anthropometric and neonatal variables were collected from all newborns. Laboratory researchers were blinded to maternal status.
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