All images were reviewed on an Extended Brilliance Workspace workstation (Philips Healthcare). Three experienced nuclear medicine physicians together reviewed the two PET datasets. Images were analysed for the number of pathologic lesions and were classified as “malignant/probably malignant lesion”, “inflammatory/probably inflammatory lesion” or “unclear lesion”. Furthermore, a simplified metabolic TNM classification (if applicable) was performed. It was defined as follows: was a primary tumour present or not (T+ or T-), did it spread to lymph nodes or not (N+ or N-) and were distant metastases present or not (M+ or M-). The presence of T+, N+ or M+ was considered a worse stage than T-, N- or M-. Patient images were anonymized and randomized, then given to the experts for interpretation. Image sets were separated by camera, and those acquired using the Gemini TF were interpreted first. The physicians were provided with basic patient information (i.e., sex, age, indication for the examination, and the clinically-written CT report). Where only a low-dose CT was performed together with the PET acquisition, the diagnostic CT performed on the other scanner (or, if a separate diagnostic CT was performed within 4–6 weeks before the PET-CT, according to routine clinical practice), was provided to the interpreting physicians (see Imaging section).
Extended brilliance workspace workstation
Manufactured by Philips
The Extended Brilliance Workspace workstation is a laboratory equipment product designed to provide a functional and organized work environment for scientific professionals. The workstation offers a comprehensive set of features to facilitate efficient and ergonomic laboratory operations.
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Lab products found in correlation
6 protocols using extended brilliance workspace workstation
1
Standardized PET Image Interpretation
2
Coronary CTA and Calcium Scoring Protocol
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Coronary CTA was performed using a 0.8-mm thickness 256-slice multi-detector CT scanner (Brilliance iCT 256; Philips Medical Systems, Best, the Netherlands).13 (link) Patients with a heart rate >65 bpm were given metoprolol 100 mg to reduce their heart rate down to ≤65 bpm. Scan parameters were as follows: tube voltage, 120 kVp; tube current, 100 mAs; 220 mm field of view; rotation time, 0.27 s/rotation; reconstructed slice thickness, 0.8-mm; signal acquisition at 80 % of the R-R interval. CACS was measured using the Extended Brilliance Workspace workstation (Philips Medical Systems) after reconstruction. CACS was automatically displayed in color by calcium scoring software. Quantitative CACS was measured with the scoring system described by Agatston.14 (link) We excluded the patients with 0 of CACS.
3
PET/CT Evaluation of Prostate Cancer
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The images were analyzed on an Extended Brilliance Workspace workstation (Philips). The scans were reread by 2 nuclear medicine clinicians with more than 10 y of experience in reporting on PET studies. Any focal prostatic uptake higher than uptake in the circumferential tissues was considered pathologic. In addition, SUV max was measured in the nearest visually defined PN tissue adjacent to the primary tumor. For patients with a multifocal primary tumor, PN SUV max was measured adjacent to the pathologic sample used for immunohistochemistry. Multifocal tumors detected on 68 Ga-PSMA PET/CT were validated using pathology reports. Intraprostatic lesions were documented using the 39sector scheme and later were correlated with the corresponding pathology findings (16) .
4
Multi-phase CT Scanning Protocols
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Multiple-phase CT scanning was performed using a 16-slice spiral CT scanner (Brilliance, Philips Healthcare, The Netherlands). All patients were positioned supine, with their feet first on the scanning table. The scanning range was from the top of the diaphragm to the lower edge of the liver. Two protocols were used: Protocol A, 90 kVp/395mAs, and Protocol B, 120 kVp/200 mAs. The pitch values of Protocols A and B were 0.813 and 0.938, respectively, which were the machine default. The other parameters used in the scan and reconstruction were the same in the 2 protocols. These parameters included: collimation 16 × 1.5 mm, reconstruction section thickness 0.625 mm, reconstruction interval 0.625 mm, field of view 350 mm, matrix 512 × 512, 2.0 mm thin slice thickness of portal venous phase image and 1.0 mm slice interval, window width 350 HU and window level 50 HU. The scan data was transferred to the post-processing Extended Brilliance Workspace (EBW) work station (Philips Healthcare, The Netherlands) and then the values were measured. The contrast agent (300 mgI/mL; Iohexol, Taizhou, China) was injected through the right antecubital vein via 18-gauge needle by power injector. The dosages for Protocols A and B were 1.2 and 1.5 mL/kg, respectively, and the rate was 2.8 to 3.0 mL/s. The delay time of portal phase was set at 50 seconds after injection.
5
Bladder Cancer Localization via MRI-Pathology Correlation
6
Standardized 18F-FDG PET/CT Imaging Protocol
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All patients underwent PET/CT examinations using the Philips TF64 PET/CT scanner. The 18 F-FDG was synthesised using a GE MINItrace cyclotron and Tracerlab FX-FDG synthesiser, with precursor reagents purchased from ABX, Germany. The synthesised 18 F-FDG had a radiochemical purity of ≥ 95%, met quality control standards, and was suitable for human injection. The patients fasted for at least 6 h, with a fasting blood glucose level of ≤ 12 mmol/L. The 18 F-FDG was injected into the vein of the contralateral upper limb of the affected breast at a dose of 370 MBq/kg body weight. Patients were encouraged to drink water and remained at rest for 60 min. The scanning range was from the skull vertex to the midthigh. The CT scan parameters were as follows: tube voltage of 120 kV, tube current of 300 mA, slice thickness of 5 mm, interslice gap of 5 mm, and 512 × 512 matrix. PET data were acquired in 3D mode for 1.5 min per bed position covering six to seven bed positions. The PET images underwent attenuation correction by using co-registered CT data and were reconstructed using iterative reconstruction and time-of-flight techniques. The image data were then transferred to the Philips Extended Brilliance Workspace (EBW) workstation for post-processing.
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