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Leptomycin b solution

Manufactured by Merck Group
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Leptomycin-B solution is a laboratory product manufactured by Merck Group. It is a chemical compound used for research purposes. The core function of Leptomycin-B solution is to inhibit the nuclear export of proteins.

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Lab products found in correlation

Necrostatin 1, by Merck Group (1 mentions) Necrosulfonamide, by Merck Group (1 mentions) Tl32711, by Selleck Chemicals (1 mentions) Tnf α neutralising antibody, by Cell Signaling Technology (1 mentions) Z vad fmk, by Merck Group (1 mentions) Entinostat, by Selleck Chemicals (1 mentions)

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Leptomycin B (86 citations)

2 protocols using leptomycin b solution

1

Investigating Cell Death Mechanisms

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TL32711 and Entinostat were obtained from Selleck Chemicals (Newmarket, UK), ASTX660 was obtained from Astex Pharmaceuticals (Cambridge, UK), z-VAD-fmk and Necrostatin-1 were purchased from Sigma-Aldrich (Gillingham, UK), GSK’874 and Necrosulfonamide from Merck (Darmstadt, Germany), recombinant TNFα from Alomone Labs (Israel), TNFα-neutralising antibody from Cell Signaling Technologies (Danvers, MA, USA) and Leptomycin-B solution was purchased from Sigma-Aldrich.
McCann C., Crawford N., Majkut J., Holohan C., Armstrong C.W., Maxwell P.J., Ong C.W., LaBonte M.J., McDade S.S., Waugh D.J, & Longley D.B. (2018). Cytoplasmic FLIP(S) and nuclear FLIP(L) mediate resistance of castrate-resistant prostate cancer to apoptosis induced by IAP antagonists. Cell Death & Disease, 9(11), 1081.
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2

Inhibiting Nuclear Export Protein CRM1

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To inhibit nuclear export protein CRM1, Leptomycin B solution (Sigma, #L2913) was used. MyLa cells were cultured for 24 h in a 12 well plate and then cells were treated with or without Leptomycin B at concentration ranging between 5 to 20 ng/mL for 3 h. After 3 h, cytoplasmic and nuclear fractions were extracted.
Vadivel C.K., Gluud M., Torres-Rusillo S., Boding L., Willerslev-Olsen A., Buus T.B., Nielsen T.K., Persson J.L., Bonefeld C.M., Geisler C., Krejsgaard T., Fuglsang A.T., Odum N, & Woetmann A. (2021). JAK3 Is Expressed in the Nucleus of Malignant T Cells in Cutaneous T Cell Lymphoma (CTCL). Cancers, 13(2), 280.
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