Piperine (≥98% purity) was procured from the Shanghai De Bai Chemical Technology Co., Ltd. Nimodipine tablets were purchased from Bayer, Germany. TTC was bought from Solarbio Life Sciences (Beijing Solarbio Science & Technology Co., Ltd). BCA protein quantitative kits and total protein extraction kits were purchased from Ken Gen Biotech. Co. Ltd. Primary antibodies of Caspase‐3, Caspase‐9, Bax, Bcl‐2, Cyt‐c, and β‐actin, as well as the secondary antibody of horseradish peroxidase‐conjugated goat antirabbit IgG were obtained from Proteintech Group, Inc. SuperSignal West Pico was bought from Thermo Scientific, US.
Nimodipine tablets
Manufactured by Bayer
Sourced in Germany
Nimodipine tablets are a pharmaceutical product manufactured by Bayer. They contain the active ingredient nimodipine, a calcium channel blocker. The core function of Nimodipine tablets is to regulate the flow of calcium into the muscle cells of blood vessels, which can help to prevent and treat certain medical conditions.
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3 protocols using nimodipine tablets
1
Neuroprotective Effects of Piperine
2
Neuroprotective Compound Analysis Protocol
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NGR1, GSRg1, GSb1, GSRd, HSYA, SI, PA, DZ, VT, and FA were all purchased from Chengdu Mansite Bio-technology Co., Ltd. (Sichuan, China), and the purity of each component was at least 98%, as verified by high-performance liquid chromatography (HPLC, Shimadzu, Kyoto, Japan). Nimodipine tablets were purchased from Bayer Healthcare Company Ltd. (Batch No. BJ29160, Leverkusen, Germany). TTC was purchased from Shanghai Shanpu Chemical Co., Ltd. (Batch No. 20140211, Shanghai, China). Assay kits for LDH, MDA, and SOD were obtained from Nanjing Jiancheng Biological Engineering Institute (Nanjing, China). D2O containing 3-(trimethylsilyl)propionic-2,2,3,3-d4 acid sodium salt (TSP) was purchased from Teng Long Technology Co., Ltd (Qingdao, China).
3
Nimodipine and Latanoprost for Glaucoma
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Patients in the control group were treated with latanoprost eye drops (Lunanbeite Pharmaceutical Co., Ltd., SFDA Approval No. H20044234), 1 drop/time, once daily. On the basis of the control group, the observation group was given nimodipine tablets (Bayer Healthcare Co., Ltd., SFDA Approval No. H20003010) orally, 30 mg/time, once a day. The treatment lasted for 6 months in both groups.
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