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Adult male sprague dawley rats

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Adult male Sprague-Dawley rats are commonly used laboratory animals. They are a widely studied rodent model that provides consistent and reliable data for research purposes.

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Lab products found in correlation

Solid rat chow, by Oriental Yeast (3 mentions) C57bl 6 mice, by Charles River Laboratories (3 mentions) Cd 1 mice, by Charles River Laboratories (2 mentions) Ketamine, by Pfizer (2 mentions) Nifedipine, by Merck Group (2 mentions) Verapamil, by Merck Group (2 mentions) K50001, by Research Diets (2 mentions) Lab diet 5001, by Purina (2 mentions) D12492, by Research Diets (1 mentions) Gapdh antibody, by Abcam (1 mentions) Doublecortin dcx, by Cell Signaling Technology (1 mentions) Mdivi 1, by Bio-Techne (1 mentions) Desipramine hydrochloride, by Merck Group (1 mentions) Rodent chow 5001, by Purina (1 mentions) High fat diet (hfd), by Research Diets (1 mentions) Male pups, by Charles River Laboratories (1 mentions) 1μm pore membranes, by BD (1 mentions) Collagenase dispase, by Roche (1 mentions) Cocaine hydrochloride, by Merck Group (1 mentions) Potassium clavulanate, by Merck Group (1 mentions)

272 protocols using adult male sprague dawley rats

1

Pharmacokinetics and Anti-Inflammatory Effects of AC

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Adult male Sprague-Dawley rats (weight, 180–220 g) with jugular vein intubation were purchased from Beijing Vital River Laboratory Animal Technology Co., Ltd (Certificate no.: SCXK (Jing) 2016–0006, Beijing, China) for pharmacokinetic study, while Adult male Sprague-Dawley rats (weight, 140–160 g) were purchased for study of anti-inflammatory effects of AC. All animals were housed at the animal facility in Tianjin Institute of Pharmaceutical Research New Drug Assessment Co., Ltd and allowed to have access to food and water freely. All animal treatments were approved by the Institutional Animal Ethical Committee of Tianjin Institute of Pharmaceutical Research (Certificate no.: SYXK (Jin) 2016–0009, Tianjin, China).
He Y., Wei Z., Xie Y., Yi X., Zeng Y., Li Y, & Liu C. (2019). Potential synergic mechanism of Wutou-Gancao herb-pair by inhibiting efflux transporter P-glycoprotein. Journal of Pharmaceutical Analysis, 10(2), 178-186.
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2

Sprague-Dawley Rat Husbandry Protocol

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Adult male Sprague-Dawley rats (8–13 weeks, 220–450 g; Charles River, Sulzfeld, Germany) were housed under standard laboratory conditions. All animal experiments were reviewed by the local ethics committee (Regierungspräsidium Darmstadt, Dezernat V 54; permit number F6/18) and performed in agreement with the German laws (TSG) for the use of animals in research.
Jungenitz T., Bird A., Engelhardt M., Jedlicka P., Schwarzacher S.W, & Deller T. (2023). Structural plasticity of the axon initial segment in rat hippocampal granule cells following high frequency stimulation and LTP induction. Frontiers in Neuroanatomy, 17, 1125623.
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3

Sprague-Dawley Rat Housing and Care

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Adult male Sprague–Dawley rats (n = 29; 8 weeks of age at arrival) were obtained from Charles River (Raleigh, NC, USA). Rats were individually housed in a temperature- and humidity-controlled vivarium and maintained on a 12-h reverse-light cycle. All procedures were carried out during the dark phase of the cycle. Animals were provided with 20 g of standard rat chow daily, and water was available ad libitum. All work was approved by the Institutional Animal Care and Use Committees of the University of Florida.
Giorgione J., Epand R.M., Buda C, & Farkas T. (1995). Role of phospholipids containing docosahexaenoyl chains in modulating the activity of protein kinase C.. Proceedings of the National Academy of Sciences of the United States of America, 92(21), 9767-9770.
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4

Sprague-Dawley Rat Care and Usage

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Adult male Sprague-Dawley rats (200–250 g; Charles River) were maintained under a 12-h light-dark cycle. Food and water were freely available in the home cage. Experimental procedures were approved by the NIDA Animal Care and Use Committee or by the National Animal Experiment Board of Finland (protocol approval number ESAVI/5459/04.10.03/2011) and followed the guidelines of the “Guide for the Care and Use of Laboratory Animals” (National Institutes of Health publication, 1996) and local laws and regulations.
Anttila J.E., Albert K., Wires E.S., Mätlik K., Loram L.C., Watkins L.R., Rice K.C., Wang Y., Harvey B.K, & Airavaara M. (2018). Post-stroke Intranasal (+)-Naloxone Delivery Reduces Microglial Activation and Improves Behavioral Recovery from Ischemic Injury. eNeuro, 5(2), ENEURO.0395-17.2018.
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5

Sprague-Dawley Rats Housing Protocol

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Adult male Sprague-Dawley rats (250–350 g; Charles River, Canada) were maintained on a 12-h light/dark cycle and allowed access to food and water ad libitum. All protocols were approved by the McGill University Animal Care Committee and complied with the policies and guidelines outlined by the Canadian Council on Animal Care and the International Association for the Study of Pain.
Magnussen C., Hung S.P, & Ribeiro-da-Silva A. (2015). Novel expression pattern of neuropeptide Y immunoreactivity in the peripheral nervous system in a rat model of neuropathic pain. Molecular Pain, 11, 31.
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6

Housing and Acclimation of Sprague-Dawley Rats

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Adult male Sprague–Dawley rats (Charles River Laboratories, Portage, MI) were allowed to acclimate to the vivarium prior to experimentation. Rats were group housed in pairs, generally with a conspecific of the same treatment group, in standard microisolator rat polycarbonate cages with bedding. Animals were allowed food and water ad libitum in their home cages and housed on a 12h light/dark cycle with lights on at 7AM. Temperature and humidity were controlled in the vivarium and behavioral testing laboratories.
Eagle A.L., Singh R., Kohler R.J., Friedman A.L., Liebowitz C.P., Galloway M.P., Enman N.M., Jutkiewicz E.M, & Perrine S.A. (2015). Single prolonged stress effects on sensitization to cocaine and cocaine self-administration in rats. Behavioural brain research, 284, 218-224.
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7

Sprague Dawley Rat Dietary Adaptation

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Adult male Sprague Dawley rats (Charles River) were singly housed in hanging wire cages in a temperature and humidity-controlled environment with a 12h/12h light cycle. Rats were given water, rodent chow (Teklad 2018), and/or rodent high fat diet [HFD; D12492 (60% kcal from fat), Research Diets] ad libitum unless otherwise noted. A 1-week minimum habituation period for the diets was allotted for all rats prior to the start of testing. All procedures were approved by the Institutional Animal Care and Use Committee at the University at Buffalo.
DiBrog A.M., Kern K.A., Mukherjee A., Przybysz J.T, & Mietlicki-Baase E.G. (2022). The alpha-7 nicotinic acetylcholine receptor agonist GTS-21 does not affect food intake in rats. Pharmacology, biochemistry, and behavior, 219, 173444.
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8

Sprague-Dawley Rat Housing Protocol

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Adult male Sprague–Dawley rats (4–6 months old, n = 4) were obtained from Charles River Laboratories. The animals were housed in the animal-specific pathogen-free facility at UTHSCSA's main campus in cages with standard wood bedding and space for two rats. The animals had free access to food and drinking water ad libitum and a 12-h shift between light and darkness. The animals were selected randomly, and the data analysis was performed by a blinded investigator.
Imam Aliagan A., Madungwe N.B., Tombo N., Feng Y, & Bopassa J.C. (2020). Chronic GPER1 Activation Protects Against Oxidative Stress-Induced Cardiomyoblast Death via Preservation of Mitochondrial Integrity and Deactivation of Mammalian Sterile-20-Like Kinase/Yes-Associated Protein Pathway. Frontiers in Endocrinology, 11, 579161.
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9

Sprague-Dawley Rat Housing Conditions

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Adult male Sprague-Dawley rats were purchased from Charles River and kept individually housed under constant environmentally controlled conditions (12/12 h light-dark cycle, 22 °C) with access to food and water ad libitum. All animal procedures were performed in accordance with the University of Michigan animal care committee’s regulations, and we confirm that the entire procedure was approved by that committee.
Luna-Munguia H., Starski P., Chen W., Gliske S, & Stacey W.C. (2017). Control of in vivo ictogenesis via endogenous synaptic pathways. Scientific Reports, 7, 1311.
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10

Sprague Dawley Rat Housing Protocol

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Adult male Sprague Dawley rats (Charles Rivers Laboratories) weighing 300–350 gm were housed in pairs in plastic cages and maintained on a 12 h light/dark cycle. Food and water were provided ad libitum throughout the experiment. Animal use procedures were in strict accordance with the National Institutes of Health Guide for the Care and Use of Laboratory Animals and were approved by the University of Texas at Dallas Animal Care and Use Committee.
de Solis C.A., Morales A.A., Hosek M.P., Partin A.C, & Ploski J.E. (2017). Is Arc mRNA Unique: A Search for mRNAs That Localize to the Distal Dendrites of Dentate Gyrus Granule Cells Following Neural Activity. Frontiers in Molecular Neuroscience, 10, 314.
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