Integrin αm

Manufactured by Santa Cruz Biotechnology

Integrin αM (also known as CD11b or Mac-1) is a subunit of the integrin αMβ2 complex, which is a cell surface receptor expressed primarily on myeloid cells such as monocytes, macrophages, and neutrophils. The core function of Integrin αM is to mediate cell-cell and cell-extracellular matrix interactions, playing a role in various cellular processes including adhesion, migration, and phagocytosis.

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2 protocols using integrin αm

Immunophenotyping of Exosomes by Antibodies

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Annexin A2, DC-SIGN, ICAM-1, Integrin β1, Integrin β3, Integrin β5, HRS, STAM1, VPS4, p-p38, p-Paxillin, p-Stat1, p-Stat3, p-Stat5, Ubiquitin, Vimentin, and β-Actin antibodies were obtained from Cell Signaling Technology (Danvers, MA). CD63, CD9, CD81, HSP70, Integrin αM, Integrin α3, Integrin α5, Annexin A6, TSG101, Alix, and GAPDH antibodies were obtained from Santa Cruz Biotechnology, Inc. (Santa Cruz, CA). LFA-1 antibody was obtained from BD Biosciences; MHC II and Fibronectin antibodies were obtained from Abcam (Cambridge, MA), and Tubulin antibody was obtained from Sigma-Aldrich (St. Louis, MO). HIV-1 p24 gag and HIV-1 gp120 antibodies were obtained from ABL (Rockville, MD) while the HIV-1 Reverse Transcriptase antibody was obtained from Invitrogen (Carlsbad, CA). APC anti-human CD63 antibody and APC Mouse IgG1, κ Isotype Ctrl (FC) were obtained from Biolegend (San Diego, CA). Exosome-depleted FBS was obtained from System Biosciences (Palo Alto, CA). β-lactose was obtained from Sigma-Aldrich (St. Louis, MO).

Kulkarni R, & Prasad A. (2017). Exosomes Derived from HIV-1 Infected DCs Mediate Viral trans-Infection via Fibronectin and Galectin-3. Scientific Reports, 7, 14787.

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Antibody Characterization in Breast Cancer

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The monoclonal antibody to human QTRT1 was purchased from Santa Cruz Biotechnology (Dallas, TX). Monoclonal antibody of β-catenin and E-cadherin from BD Transduction (San Jose, CA), and β-actin were purchased from Sigma-Aldrich (St. Louis, MO). Monoclonal antibody of PCNA and CD11b (Integrin αM) were purchased from Santa Cruz Biotechnology (Dallas, TX). Claudin 5 and Claudin 2 mouse monoclonal antibody and ZO-1 rabbit monoclonal antibody were purchased from Thermo Fisher Scienti c (Rockford, IL). CD68 rabbit polyclonal antibody was purchased from Abcam (Cambridge, MA). All chemicals were purchased from Sigma-Aldrich unless otherwise stated. The breast cancer cell lines, including MCF7 and MDA-MB-231, were provided by Dr. Tao Pan's lab at University of Chicago.

Zhang J., Lu R., Zhang Y., Matuszek Ż., Xia Y., Pan T., & Sun J. (2020). tRNA queuosine modification enzyme modulates the growth and microbiome recruitment to breast tumors.

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