The clinical efficacy of the topical test product facial skin rejuvenation was assessed at baseline and 3 weeks after the initiation of treatment. The skin barrier function and skin hydration were evaluated using Corneometer® and Tewemeter® (Courage Khazaka Electronic GmbH, Köln, Germany). Skin elasticity was measured using Cutometer Dual MPA580 (Courage Khazaka Electronics, Köln, Germany), while skin density was additionally measured using Ultrascan® UC22 (Courage Khazaka electronic, Germany), a device that measured the density of the skin by generating a short electric pulse using a 22 MHz ultra-sonic transducer. Lastly, the melanin index and erythema index of the skin were measured using the Mexameter MX18 (Courage Khazaka Electronic GmbH, Köln, Germany). Each measurement was performed thrice during each visit, and we instructed all participants to acclimatize to the controlled environmental conditions for 30 min at each visit (room temperature: 18–21 °C; relative humidity: 40–60%, without direct light), before the measurement.
Ultrascan uc22
Manufactured by Courage + Khazaka
Sourced in Germany
The Ultrascan UC22 is a non-invasive instrument designed for the measurement of skin parameters. It utilizes ultrasound technology to assess the skin's structure and properties.
Automatically generated - may contain errors
3 protocols using ultrascan uc22
1
Evaluating Topical Facial Skin Rejuvenation
2
Efficacy of Ato Repair Solutions on Skin Parameters
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The clinical efficacy of Ato Repair Solutions after 4 weeks of using the product was evaluated at baseline, week 2, and week 4. Cutometer Dual MPA580 (Courage Khazaka electronic GmbH, Köln, Germany), Ultrascan UC22 (Courage + Khazaka electronic GmbH), and Antera 3D CS (Miravex, Dublin, Ireland), Tewameter TM300 (Courage Khazaka electronic, GmbH) were used to measure skin density, skin elasticity, changes in the depth of periorbital wrinkles, and TEWL, respectively. Adverse events were also recorded, and participants were asked to rate their satisfaction with the efficacy of the products using a questionnaire at the end of the trial of 4 weeks (Table S2 ). The questionnaire evaluation was conducted on a five‐point scale (very satisfied = 5, satisfied = 4, slightly satisfied = 3, no change = 2, not satisfied = 1), and the scores of 3 or more were considered positive responses and presented as a result.
3
Evaluating Periocular Wrinkle Reduction
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The participants were assessed at the beginning of the treatment and at 1, 2, 4, and 8 weeks of treatment regimen. A-One Pro digital skin image analysis equipment (Bomtech Electronics Co., Seoul, Korea) for objective evaluation of wrinkle degree and 3-dimensional (3D) skin image of periocular wrinkles was used during each visit. Dermal density and dermal depth were measured by ultrasonic equipment, Ultrascan UC22 (Courage Khazaka Electronics, Cologne, Germany). The severity of periocular wrinkles was assessed according to a 5-point photonumeric scale. The scale ratings are: 0 for no wrinkles, 1 for very fine wrinkles, 2 for fine wrinkles, 3 for moderate wrinkles, and 4 for severe wrinkles15 (link). At the end of the study, the patients documented their degree of satisfaction as very satisfied, satisfied, slightly satisfied, or unsatisfied. Patients were also asked to report any side effects during each visit.
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