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Atri azd6738

Manufactured by Selleck Chemicals
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ATRi AZD6738 is a laboratory product that functions as an Ataxia Telangiectasia and Rad3-related (ATR) kinase inhibitor. It is designed for use in scientific research applications.

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Lab products found in correlation

Celltiter glo, by Promega (1 mentions) Ve 821, by Selleck Chemicals (1 mentions) 5 ethynyl 2 deoxyuridine (edu), by Thermo Fisher Scientific (1 mentions) γh2ax, by Cell Signaling Technology (1 mentions) Axioimager widefield microscope, by Zeiss (1 mentions) Ro 3306, by Selleck Chemicals (1 mentions)

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AZD6738 (50 citations)

2 protocols using atri azd6738

1

ATRi Cell Viability Assay

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For the MLH1 KO cell viability assay, cells were cultured in ATRi AZD6738 or VE-821 (Selleck Chemicals) for 4–5 d before cell viability was examined using CellTiter-Glo (Promega) according to the manufacturer's instructions. For the siRNA transfected cell viability assay, cells transfected with the indicated siRNAs were cultured in ATRi AZD6738 or VE-821 (Selleck Chemicals) for 5 d before cell viability was examined using CellTiter-Glo (Promega) according to the manufacturer's instructions.
Wang M., Ran X., Leung W., Kawale A., Saxena S., Ouyang J., Patel P.S., Dong Y., Yin T., Shu J., Manguso R.T., Lan L., Wang X.F., Lawrence M.S, & Zou L. (2023). ATR inhibition induces synthetic lethality in mismatch repair-deficient cells and augments immunotherapy. Genes & Development, 37(19-20), 929-943.
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2

Nascent DNA and γ-H2AX Analysis

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Cells transfected with the indicated siRNAs or treated for 20 h with 10 µM RO-3306 (Selleck Chemicals) were incubated for 20 min with 10 µM EdU (Thermo) followed by 2 µM ATRi AZD6738 (Selleck Chemicals) for 4 h. Cells were subsequently fixed, permeabilized, and stained for nascent DNA using click chemistry (Thermo) and γ-H2AX (Cell Signaling Technologies). Cells were imaged using an Axioimager wide-field microscope (Zeiss).
Wang M., Ran X., Leung W., Kawale A., Saxena S., Ouyang J., Patel P.S., Dong Y., Yin T., Shu J., Manguso R.T., Lan L., Wang X.F., Lawrence M.S, & Zou L. (2023). ATR inhibition induces synthetic lethality in mismatch repair-deficient cells and augments immunotherapy. Genes & Development, 37(19-20), 929-943.
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