C57BL/6 female mice (18-months old) were purchased from the National Institute on Aging, and C57BL/6 male mice (18-months old) were purchased from Jackson Labs. C57BL/6 (strain #000664, 1-month old) females, Cxcl12fl/fl (strain #021773), mTmG mice (strain #007676), Cdkn1a−/− mice (strain #003263), and K14-CreER (strain #5107) were purchased from The Jackson Laboratory. All mice were group housed in the animal facility of University of Pennsylvania on a 12-hour light/12-hour dark cycle with ad libitum access to water and normal chow. K5-rtTA; tetO-Cre mice were a generous gift from Sarah Millar (University of Pennsylvania). Mice were verified by genotyping. To delete alleles, we administered doxycycline food pellets (6gm/kg, Bio-Serv) for one week or administered 1 mg of tamoxifen (diluted in corn oil) daily by intraperitoneal injection for 5 days. Mice used in this study were female age-matched littermates that were randomly assigned to experimental groups, except for SDF1KOker experiments where both male and female mice were used and the DZNep aged mouse experiment where male mice were used. No sex-dependent differences were observed.
Cdkn1a mice
Manufactured by Jackson ImmunoResearch
Cdkn1a−/− mice are genetically engineered mice that have a targeted deletion of the Cdkn1a gene. The Cdkn1a gene encodes the cyclin-dependent kinase inhibitor p21, which plays a role in cell cycle regulation. The deletion of this gene results in the absence of the p21 protein.
Automatically generated - may contain errors
Lab products found in correlation
C57bl 6 male mice, by Jackson ImmunoResearch (2 mentions)
Doxycycline food pellets, by Bio-Serv (2 mentions)
Cxcl12fl fl, by Jackson ImmunoResearch (2 mentions)
K14creer, by Jackson ImmunoResearch (2 mentions)
C57bl 6, by Jackson ImmunoResearch (2 mentions)
Mt mg mice, by Jackson ImmunoResearch (2 mentions)
2 protocols using cdkn1a mice
1
Aged Mice and Conditional Knockout Studies
2
Aged Mice and Conditional Knockout Studies
Check if the same lab product or an alternative is used in the 5 most similar protocols
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C57BL/6 female mice (18-months old) were purchased from the National Institute on Aging, and C57BL/6 male mice (18-months old) were purchased from Jackson Labs. C57BL/6 (strain #000664, 1-month old) females, Cxcl12fl/fl (strain #021773), mTmG mice (strain #007676), Cdkn1a−/− mice (strain #003263), and K14-CreER (strain #5107) were purchased from The Jackson Laboratory. All mice were group housed in the animal facility of University of Pennsylvania on a 12-hour light/12-hour dark cycle with ad libitum access to water and normal chow. K5-rtTA; tetO-Cre mice were a generous gift from Sarah Millar (University of Pennsylvania). Mice were verified by genotyping. To delete alleles, we administered doxycycline food pellets (6gm/kg, Bio-Serv) for one week or administered 1 mg of tamoxifen (diluted in corn oil) daily by intraperitoneal injection for 5 days. Mice used in this study were female age-matched littermates that were randomly assigned to experimental groups, except for SDF1KOker experiments where both male and female mice were used and the DZNep aged mouse experiment where male mice were used. No sex-dependent differences were observed.
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