Zx3 vortex mixer

An Agilent 1100 Series chromatography system comprising a degasser, a quaternary pump, an autosampler, and a thermostatic column oven coupled to an Agilent 6410B Triple Quad MS/MS was employed throughout the study.
A 10-position multiple stirring plate model MS-M-S10 from DLAB Scientific Europe S.A.S (Schiltigheim, France) and NdFeB magnets (54MGO, 10 mm length × 3 mm diameter) from Supermagnete (Gottmadingen, Germany) were used for SBSDME.
A ZX3 vortex mixer from VELP Scientifica (Usmate Velate, Italy) and an Ultrasons-HD ultrasonic bath from JP Selecta (Barcelona, Spain) were used in the synthesis stage.
A Jenway 6305 UV/Vis spectrophotometer from Cole-Parmer Ltd (Staffordshire, UK) was used for the determination of creatinine in urine samples.
A Basic 20 pH meter from Crison (Alella, Spain) was used for the pH adjustments.
All those instruments used for characterization of the sorbent material are listed in ESM.

To prepare the recharging solutions, CPP-ACP paste (Tooth Mousse, GC, Tokyo, Japan) (S1 Table) and deionized water were used at a ratio of 1:3 [33 (link)]. Each 5 ml of deionized water was stirred with 1.7 g CPP-ACP in a vortex machine (ZX3 Vortex Mixer, VELP Scientifica, Usmate Velate MB, Italy) at a power setting of 3 for 1 min [26 (link)]. Tooth Mousse contains 10% CPP-ACP with 325 mM calcium and 187 mM phosphate [34 (link), 35 ].