LA (purity ≥ 99%) was procured from "Sigma Aldrich (St. Louis, MO, USA)". CSO was procured from "Jolly Chic (Riyadh, Saudi Arabia)". Propylene glycol monocaprylate type II (Capryol-90 ® ), diethylene glycol monoethyl ether (Carbitol ® ), polyoxyl 35 castor oil (Cremophor-EL ® ), caprylocaproyl polyoxyl-8 glycerides (Labrasol ® ) , propylene glycol dicaprolate/dicaprate (Labrafac ® ), and polyglyceryl-3 dioleate (Pleurol oleique ® ) were procured from "Gattefosse (Lyon, France)". Polyoxyethylenesorbitan monolaurate (Tween 20 ® ), polyoxyethylenesorbitan monooleate (Tween 80 ® ), polyethylene glycol-200 (PEG-200), and ethanol were procured from "Hi-Media (Mumbai, India)". HPLC grade toluene, acetone, and glacial acetic acid were procured from "Fluka Chemica (Darmstadt, Germany)". Deionized water (DW) was procured from "Milli-Q water purification system (Millipore, Billerica, MA, USA)". Dialysis membrane (MWCO: 12000-14000 D) was from "Sigma Aldrich (St. Louis, MO, USA)". All other chemical and reagents used for the study were of analytical grade and procured from an approved vendor.
Cremophor el
Manufactured by Gattefosse
Sourced in France
Cremophor EL is a nonionic solubilizer and emulsifier. It is a polyethoxylated castor oil used to improve the solubility and bioavailability of various active pharmaceutical ingredients.
Automatically generated - may contain errors
Lab products found in correlation
Capryol 90, by Gattefosse (3 mentions)
Labrasol, by Gattefosse (3 mentions)
Compritol 888 ato, by Gattefosse (3 mentions)
Peceol, by Gattefosse (3 mentions)
Stearic acid, by Daejung Chemicals (3 mentions)
Lauroglycol fcc, by Gattefosse (3 mentions)
Labrafil m 1944 cs, by Gattefosse (3 mentions)
Oleic acid, by Samchun (3 mentions)
Precirol ato 5, by Gattefosse (3 mentions)
Capryol pgmc, by Gattefosse (2 mentions)
Tween 20, by Samchun (2 mentions)
Gelucire 44 14, by Gattefosse (2 mentions)
Solutol hs 15, by BASF (2 mentions)
Tween 80, by Samchun (2 mentions)
Methanol, by Avantor (2 mentions)
Glyceryl monostearate, by Samchun (2 mentions)
Labrafac cc, by Gattefosse (2 mentions)
Milli q water purification system, by Merck Group (1 mentions)
Poly ethylene glycol 200 peg 200, by HiMedia (1 mentions)
Labrafac, by Gattefosse (1 mentions)
6 protocols using cremophor el
1
Optimizing Lipid-Based Formulations for Improved Delivery
2
Formulation and Evaluation of Solid Dosage Forms
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Methocel K4M (Colorcon Ltd.), Carbopol 974P (Lubrizol), Cremophor EL (Gattefosse), Solutol HS15 (Gattefosse), Transcutol P (Gattefosse), Aerosil 200 (Evonik), Hard gelatin capsules (ACG capsules) were obtained as gift samples. Mannitol, Magnesium stearate, Tween 80, PEG 400 and sodium alginate were purchased from SD Fine Chemicals Ltd. All other reagents and chemicals were of AR grade.
3
Optimization of Ovarian Cancer Drug Formulations
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PT and docetaxel (internal standard, IS) were gifted by Korea United Pharm, Inc. (Seoul, Korea). Isopropyl palmitate, palmitic, myristic and stearic acid were purchased from Daejung Chemical (Cheongwon, Korea). Tween 80, Tween 20, GMS, oleic acid, Span 85 and 80, phosphoric acid and mannitol were obtained Samchun Chemical (Pyungtaek, Korea). Capmul® MCM-NF and -EP were purchased from Abitec Corporation (Columbus, OH, USA). Gelucire 44/14, 33/01, 43/01, 50/13, Capryol™ PGMC, Compritol® 888 ATO, Capryol 90, Labrafac™ WL 1349 and CC, Labrasol, Cremophor® EL, Labrafil® M 2125 CS, Peceol, Lauroglycol 90, Transcutol® HP, Lauroglycol™ FCC, precirol ATO, and Labrafil® M 1944 CS were obtained by Gattefossé (Saint Priest, Cedex, France). Poloxamer 188, 407 and Solutol® HS-15 were obtained from BASF (Ludwigshafen, Germany). Dimethyl sulfoxide (DMSO), DAPI, 3-(4,5-dimethylthoazol-2yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) and rhodamine–phalloidin were obtained from Sigma-Aldrich (St. Louis, MO, USA). SK-OV-3 cells, an ovarian cancer cell line, were obtained from the Korean Cell Line Bank (Seoul, Korea). High-performance liquid chromatography (HPLC)-grade methanol (MeOH) and acetonitrile (ACN) were obtained from JT Baker (Phillipsburg, NJ, USA).
4
Naringenin and TQ oil-based formulations
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Naringenin and TQ oil were purchased as gift samples from Sigma-Aldrich Co. (Spruce St Saint Louis, MO, USA). Gelucire 39/01, glyceryl monostearate, Compritol, Precirol ATO-5, Labrafil M 2130 CS, and Cremophor-EL were purchased from Gattefosse India Pvt. Ltd (Mumbai, India). Ascorbic acid and Rhodamine B were purchased from Sigma-Aldrich (Mumbai, India). Methanol and ethanol were obtained from Merck (Mumbai, India). 1,1-Diphenyl-2-picrylhydrazyl and 5,5′-dithiobis-2-nitrobenzoic acid were purchased from Sigma-Aldrich Chemicals Pvt. Ltd. (Bangalore, Karnataka, India). Sefsol® 218 was purchased from S D Fine Chem Limited (Mumbai, India). All other purchased solvents and chemicals were of analytical grade.
5
Formulation and Evaluation of Lipid-Based Nanocarriers
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TGL was a gift from the Korea United Pharm Inc. (Seoul, Korea). High-performance liquid chromatography (HPLC) grade acetonitrile and methanol were used and purchased from JT Baker (Phillipsburg, NJ, USA). Capmul MCM (Glyceryl Caprylate/Caprate) was purchased from Abitec Corporation (Columbus, OH, USA). Stearic acid, palmitic acid, and myristic acid were obtained from Daejung Chemical (Cheongwon, Korea). Tween 80 and 20, Span 80 and 85, olive oil, oleic acid, and glyceryl monostearate were provided by Samchun Chemical (Pyungtaek, Korea). Gelucire 44/14, 50/13, 33/01 and 43/01, Capryol PGMC and 90, Compritol 888 ATO, Precirol ATO 5, Labrafac CC, Peceol, Labrafil M 1944 CS, Lauroglycol FCC, Lipophile WL 1349, Labrasol, Cremophor EL were purchased from Gattefossé (Saint-Priest, Cedex, France). Solutol HS-15, Poloxamer 188 and 407 were purchased from BASF (Ludwigshafen, Germany). Coumarin-6 (C6) and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) were purchased from Sigma-Aldrich (St. Louis, MO, USA). 4′,6-diamidino-2-phenylidone (DAPI) was purchased from Thermo Fisher Scientific (Waltham, MA, USA). All the reagents were of analytical grade and obtained from commercial sources.
6
Formulation and Evaluation of Curcumin Nanoparticles
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EGF, curcumin, 3-(4,5-dimethylthoazol-2yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT), and ethylenediaminetetraacetic acid (EDTA) were obtained from Sigma-Aldrich (St. louis, MO, USA). Dimethyl sulfoxide (DMSO), olive oil, oleic acid, glyceryl monostearate (GMS), Tween 80, and Tween 20 were purchased from Samchun Chemical (Pyungtaek, Korea). Stearic acid was provided from Daejung Chemical (Cheongwon, Korea). Precirol ATO 5, Compritol 888 ATO, Capryol 90, Capryol PGMC, Labrafac CC, Labrafil M 1944 CS, Peceol, Lauroglycol FCC, Labrafac WL 1349, and Cremophor EL were obtained from Gattefossé (Saint Priest, Cedex, France). Lutrol F-68 (poloxamer 188) and Lutrol F-127 (poloxamer 407) were provided by BASF (Ludwigshafen, Germany). NIH 3T3 and HaCaT cells were obtained from the Korean Cell Line Bank (Seoul, Korea). Dulbecco’s modified Eagle’s medium (DMEM), fetal bovine serum (FBS), penicillin–streptomycin, and trypsin–EDTA were purchased from Gibco BRL (Gaithersburg, MD, USA). Methanol was obtained from JT baker (Phillipsburg, NJ, USA).
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