Architect c16000 automated analyzer

Manufactured by Abbott

Sourced in United Kingdom

The Abbott Architect c16000 is an automated clinical chemistry analyzer designed for high-volume testing in laboratory settings. It is capable of performing a wide range of diagnostic tests using various sample types. The core function of the Architect c16000 is to analyze patient samples and provide accurate and reliable results to aid in medical diagnosis and treatment.

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Lab products found in correlation

Multigent iron kit, by Abbott (2 mentions) Microtainer sst tube, by BD (2 mentions) Modular analytics e170, by Roche (1 mentions) Cell dyn 3700 device, by Abbott (1 mentions) Bathophenanthrolinedisulphonic acid, by Merck Group (1 mentions) Cobas c8000 analyzer, by Roche (1 mentions)

5 protocols using architect c16000 automated analyzer

Reproductive Hormone and Metabolic Profiling

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Blood samples were collected at baseline and every follow-up after overnight fasting. If women with menopausal symptoms had menstrual cycles, blood samples were collected on days 2 to 5 of the follicular phase. If not, blood was collected at the time of interview. The reproductive hormones were determined by an automated Roche Modular Analytics E170 analyzer (Roche Diagnostics, Mannheim, Germany). Metabolic profiles were determined by an Architect c16000 automated analyzer (Abbott Laboratories, Abbott Park, IL).

Qi T., Wang X., Huang Y., Song Y., Ma L., Ying Q., Chatooah N.D., Lan Y., Chen P., Xu W., Chu K., Ruan F, & Zhou J. (2022). Change in metabolic parameters and reproductive hormones from baseline to 6-month hormone therapy. Medicine, 101(1), e28361.

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Fasting Blood Measurements and Lipid Profiles

Cited 1 time

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Fasting blood samples were obtained at screening, batched and analyzed at the Ligand Assay & Analysis Core Laboratory at University of Virginia (13 (link), 14 (link)). All assays had intra-assay and inter-assay coefficients of variation (CV) below 10% (14 (link)). Total testosterone (T) and proinsulin were measured using RIA (14 (link)). The testosterone RIA has been previously shown to be similar to commonly used liquid chromatography-tandem mass spectrometry assays (19 (link)). Sex hormone binding globulin (SHBG) and insulin were measured by chemiluminescent two-site assay. Free Androgen index (FAI) was calculated from results of total T and SHBG using the formula: (FAI = total T in nmol/L/SHBG in nmol/L × 100) as previously described (20 (link)). Glucose was measured by the glucose oxidase method. Lipid profiles including total cholesterol, high-density lipoprotein cholesterol, and triglycerides were measured using the Abbott Architect c16000 automated analyzer. Low density lipoprotein (LDL) cholesterol was calculated using the standard Friedewald equation.

Engmann L., Jin S., Sun F., Legro R.S., Polotsky A.J., Hansen K.R., Coutifaris C., Diamond M.P., Eisenberg E., Zhang H, & Santoro N. (2017). Racial and Ethnic Differences in the Polycystic Ovary Syndrome (PCOS) Metabolic Phenotype. American journal of obstetrics and gynecology, 216(5), 493.e1-493.e13.

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Comprehensive Blood Profiling for Cardiovascular Risk

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Blood samples were taken from peripheral veins of patients who fasted overnight. Auto-analyzers were used to evaluate hematological results. Abbott Cell-Dyn 3700 device was used for total or differentiated leukocyte counts. Abbott Architect C16000 automated analyzer (Abbott Lab, Abbott Park, IL, USA) was used for total and specific high-density lipoprotein (HDL) cholesterol, triglycerides and fasting blood glucose levels. The Friedewald equation was used to calculate serum low-density lipoprotein (LDL) cholesterol concentrations. The participants in the patient group applied to the hospital in the early period after the onset of symptoms, and their laboratory parameters were checked on the day of the mps recording. The time between MPS and symptom onset was short. The laboratory parameters of the participants in the control group were checked at the time of application and cardiovascular stress test was performed on the same day.

Akın Y., Karasu M., Deniz A., Mirzaoğlu Ç, & Bolayır H.A. (2023). Predictive value of the systemic immune inflammatory index in cardiac syndrome x. BMC Cardiovascular Disorders, 23, 146.

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Non-heme Iron Content Determination

Cited 1 time

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Tissues were dried for 3 hours at 100°C, and the dry mass of tissue piece was measured. Tissue pieces were digested in 10% trichloroacetic acid/ 30% hydrochloric acid for 20 hours at 65°C. Non-haem iron content was determined by reaction of the acid digested tissue with chromogen reagent containing 0.1% (w/v) bathophenanthrolinedisulphonic acid (Sigma, 146617) and 0.8% thioglycolyic acid (Sigma, 88652) measuring absorption at 535nm and comparing to a standard curve of ferric ammonium citrate as described.⁵⁴ (link)
For serum analysis of murine samples up to 400μl of blood obtained by cardiac puncture was placed in a BD microtainer SST tube (Beckton Dickinson). Serum was obtained by spinning the clotted blood sample was spun at 8,000 g for 5 minutes and stored at −80°C. Serum iron was quantified using the Abbott Architect c16000 automated analyzer (Abbott Laboratories) and the MULTIGENT Iron Kit at Oxford John Radcliffe Hospital, UK.

Frost J.N., Tan T.K., Abbas M., Wideman S.K., Bonadonna M., Stoffel N.U., Wray K., Kronsteiner B., Smits G., Campagna D.R., Duarte T.L., Lopes J.M., Shah A., Armitage A.E., Arezes J., Lim P.J., Preston A.E., Ahern D., Teh M., Naylor C., Salio M., Gileadi U., Andrews S.C., Dunachie S.J., Zimmermann M.B., van der Klis F.R., Cerundolo V., Bannard O., Draper S.J., Townsend A.R., Galy B., Fleming M.D., Lewis M.C, & Drakesmith H. (2021). Hepcidin-Mediated Hypoferremia Disrupts Immune Responses to Vaccination and Infection. Med (New York, N.y.), 2(2), 164-179.e12.

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Serum Hepcidin and Iron Quantification

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Blood was taken by cardiac puncture immediately after euthanising mice. Serum was prepared by centrifugation of clotted blood at 8000 x g for 5minutes in BD Microtainer SST tubes (Beckton Dickinson). Serum hepcidin was quantified by competitive ELISA using the Hepcidin-Murine Compete Kit (Intrinsic Lifesciences) according to the manufacturer’s protocol. For mice given FeSO₄ gavage, serum iron was quantified using the MULTIGENT Iron Kit on the Abbott Architect c16000 automated analyzer (Abbott Laboratories) at John Radcliffe Hospital, UK. For Hfe^−/− and Hamp1^−/− mice given CDDO-Im, serum irons were quantified in a Cobas C8000 analyzer (Roche Diagnostics, Mannheim, Germany) at Centro Hospitalar do Porto.

Lim P.J., Duarte T.L., Arezes J., Garcia-Santos D., Hamdi A., Pasricha S.R., Armitage A.E., Mehta H., Wideman S., Santos A.G., Santos-Gonçalves A., Morovat A., Hughes J.R., Soilleux E., Wang C.Y., Bayer A.L., Klenerman P., Willberg C.B., Hartley R.C., Murphy M.P., Babitt J.L., Ponka P., Porto G, & Drakesmith H. (2019). Nrf2 controls iron homeostasis in haemochromatosis and thalassaemia via Bmp6 and hepcidin. Nature metabolism, 1(5), 519-531.

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