μctvol v2

Manufactured by Bruker

The μCTVol v2.0 is a high-resolution X-ray micro-computed tomography (micro-CT) system designed for 3D imaging and analysis of small samples. The system utilizes advanced X-ray technology to capture detailed, non-destructive images of the internal structure and composition of a variety of materials and samples.

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Lab products found in correlation

Nrecon v1, by Bruker (2 mentions) Ctan v1, by Bruker (2 mentions) Skyscan 1174, by Bruker (2 mentions)

2 protocols using μctvol v2

Subchondral Bone Microarchitecture Analysis

Cited 1 time

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MicroCT analysis of the tibial subchondral bone was performed as previously described (Su et al., 2020 (link); Zhen et al., 2013 (link)). The knee joint was analyzed by μCT (voltage, 65 kVp; current, 153 μA; resolution, 9 μm/pixel) (Skyscan 1174, Bruker MicroCT, Kontich, Belgium). The parameters of the tibia subchondral bone image were analyzed using reconstruction software (NRecon v1.6, Bruker), data analysis software (CTAn v1.9, Bruker), and three-dimensional model visualization software (μCTVol v2.0, Bruker). Three-dimensional structural parameters analyzed were BV/TV, Tb.Pf, Tb.Th, Tb.N, and SBP.Th. Ten consecutive images from the whole subchondral bone medial compartment were used to do three-dimensional reconstruction and analysis.

Su W., Liu G., Mohajer B., Wang J., Shen A., Zhang W., Liu B., Guermazi A., Gao P., Cao X., Demehri S, & Wan M. (2022). Senescent preosteoclast secretome promotes metabolic syndrome associated osteoarthritis through cyclooxygenase 2. eLife, 11, e79773.

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Microstructural Analysis of Subchondral Bone

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The isolated knee joints were fixed overnight with 4% formaldehyde and analyzed using microCT (Sky-scan 1174, Bruker MicroCT) (voltage, 65 kVp; current, 153 μA; and resolution, 9 μm/pixel). We used image reconstruction software (NRecon v1.6, Bruker), data analysis software (CTAn v1.9, Bruker), and 3-dimensional model visualization software (μCTVol v2.0, Bruker) to analyze the parameters of the tibia subchondral bone. The whole subchondral bone medial compartment was the region of interest, and 100 consecutive images from the medial tibial plateau were used for 3-dimensional reconstruction and analysis. The bone mineral density BMD and bone volume/tissue volume (BV/TV) were measured in three-dimensional structures.

Tang H., Zhu W., Cao L., Zhang J., Li J., Ma D, & Guo C. (2022). miR-210-3p protects against osteoarthritis through inhibiting subchondral angiogenesis by targeting the expression of TGFBR1 and ID4. Frontiers in Immunology, 13, 982278.

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