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Iopamidol 370

Manufactured by Bayer
Sourced in Japan

Iopamidol 370 is a water-soluble, non-ionic, high-osmolar contrast medium used for diagnostic imaging procedures. It contains the active ingredient iopamidol, which is an iodinated compound that enhances the visibility of internal structures during medical imaging scans.

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3 protocols using iopamidol 370

1

Surgical Induction of Intestinal Obstruction and Mesenteric Vascular Occlusion

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The right femoral artery was exposed using the cut-down method, and a 4-Fr introducer sheath (Super sheath, length: 7 cm, Medikit, Tokyo, Japan) was inserted into the aorta. A 4-Fr cobra-shaped catheter (Terumo Clinical Supply, Gifu, Japan) was inserted into the superior mesenteric artery. Angiography was carried out using a fluoroscopic system (Plessart 50 DREX-WIN20P, Canon Medical Systems, Tochigi, Japan) with a tube voltage of 70 kV and a tube current of 50 mA. Angiography via the superior mesenteric artery using 5 mL of iodine contrast medium (370 mg I/mL, Iopamidol 370, Bayer Yakuhin, Osaka, Japan) was performed manually both before and after creating the strangulated SBO (Fig. 3), MVO models (Fig. 4), and sham surgery models. We judged the success in creating the strangulated SBO model by the defect of the mesenteric artery and vein in the ligated lesion, that for the MVO model was judged by depicting the mesenteric artery and the defect of the mesenteric vein, and that for sham surgery group was judged by no change after the surgical procedure compared with the findings before the procedure.
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2

Quantifying Pulmonary Embolism Volume on CT

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All CT studies were performed using a 64- to 128- MDCT scanner (SOMATOM Definition Edge or SOMATOM Definition Flash; Siemens, Erlangen, Germany). At an injection rate of 4 mL/s using a power injector, 100 mL of nonionic iodinated contrast medium (IOPAMIDOL 370, Bayer, Leverkusen, Germany, or IOHEXOL, Fuji Pharma, Tokyo, Japan) was administered intravenously. A dataset of 1–5 mm thick sections was transferred to the workstation. Contours were manually defined on several transverse sections after identifying a filling defect as far as it was visually recognizable down to the subsegmental arteries. The workstation automatically interpolated the contours between these selected sections and calculated the pulmonary embolus volume. If multiple emboli were found, the sum of each volume was used as the pulmonary clot volume (Fig. 1).

Methods of measuring clot volume using CT. (A) CT shows thrombus in left pulmonary artery (arrow). (B) Manually select the range of thrombus (arrow) in each slice. (C) The workstation automatically calculated the pulmonary embolus volume

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3

Helical CT Scanning Protocol for Lung Imaging

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The CT scans were obtained using a helical technique with a 16-detector-row CT scanner (Toshiba Aquilion 16) or a 64-detector-row CT scanner (Toshiba Aquilion 64 and SOMATOM Definition, Siemens). Helical CT scans were obtained from the lung apex to the lung base. For all multi-detector-row CT scans, a section thickness of 1 mm, a helical pitch of 0.9, a reconstruction interval of 1 mm, a reconstruction with a lung kernel (FC51) and a mediastinum kernel (FC13), a tube potential of 120 kVp, and a tube current of 150 mA were used for scanning and image reconstruction. In 258 (80.4%) out of 321 cases, contrast-enhanced CT scans were performed using contrast media (Iopamidol 370; Bayer Yakuhin, Osaka) at 4.0 mL/s (total volume, 1 mL/kg) with a 20-mL saline chaser at 4.0 mL/s.
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