Pyris v 11

Physical state analysis of ITR, CS, PLGA, physical mixture (drug + polymers), ITR-PLGA NPs, and CS-ITR-PLGA NPs was conducted using a DSC-8000 (Perkin Elmer Instruments, Shelton, CT, USA). The results were analyzed using PYRIS V-11 software (Perkin Elmer Instruments, Shelton, CT, USA). The thermal behavior of the samples was performed at a scanning rate of 10 °C/min with the temperature range 30–300 °C.

The thermogravimetric/derivative thermogravimetric (TG/DTG) and differential scanning calorimetry (DSC) analyses of the ENC suspensions were conducted with a Perkin-Elmer (Waltham, MA, USA) STA6000 simultaneous thermal analyzer by heating the sample (4.59 mg) in a slow stream of N₂ (20 mL min⁻¹) from room temperature up to 400 °C, at a heating rate of 20 °C min⁻¹. The data analysis was performed using the Perkin Elmer Pyris v.11 software. Additional TG/DTG measurements up to 900 °C were carried out with a TA Instruments (New Castle, DE, USA) Q-500 apparatus, at a heating rate of 10 °C min⁻¹, under N₂ flow (20 mL min⁻¹).